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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Teucrium


High impact information on Teucrium

  • CONCLUSIONS: We conclude that germander constituents (probably its furano neo-clerodane diterpenoids) are transformed by cytochromes P450 (particularly P4503A) into hepatotoxic metabolites [2].
  • By Western blotting and immunocytochemistry, human microsomal EH was shown to be present in purified plasma membranes of both human hepatocytes and transformed spheroplasts and to be exposed on the cell surface where affinity-purified germander autoantibodies recognized it as their autoantigen [3].
  • In this study, we describe the presence of anti-microsomal epoxide hydrolase (EH) autoantibodies in the sera of patients who drank germander teas for a long period of time [3].
  • Most importantly, the tetrahydrofuran analog of teucrin A, obtained by selective chemical reduction of the furan ring, was not hepatotoxic, a result that provides strong evidence that oxidation of the furan ring moiety of the neoclerodane diterpenes is involved in the initiation of hepatocellular injury caused by germander [4].
  • The direct qualification and quantification of the volatile components of Teucrium chamaedrys was studied using a direct thermal desorption (DTD) technique with comprehensive two-dimensional (2D) gas chromatography-time-of-flight mass spectrometry (GC x GC-TOF/MS) [5].

Associations of Teucrium with chemical compounds

  • Other examples are pulegone present in essential oils from many mint species; and teucrin A, a diterpenoid found in germander (Teuchrium chamaedrys) used as an adjuvant to slimming diets [6].
  • Teucrol, a decarboxyrosmarinic acid and its 4'-O-triglycoside, teucroside from Teucrium pilosum [7].
  • The presence of phenylpropane glycosides can therefore be used to distinguish between the S. lateriflora L. and the two Teucrium species by LC-UV and TLC [8].
  • This flavonoid glycoside had previously been reported from some Teucrium species (Labiatae), yet without sufficient physical data and spectroscopic evidence [9].
  • Extensive pulegone metabolism generated p-cresol that was a glutathione depletory, and the furan ring of the diterpenoids in germander was oxidized by CYP3A4 to reactive epoxide which reacts with proteins such as CYP3A and epoxide hydrolase [6].

Gene context of Teucrium


  1. Herbal remedies: effects on clinical laboratory tests. Dasgupta, A., Bernard, D.W. Arch. Pathol. Lab. Med. (2006) [Pubmed]
  2. Hepatotoxicity of germander in mice. Loeper, J., Descatoire, V., Letteron, P., Moulis, C., Degott, C., Dansette, P., Fau, D., Pessayre, D. Gastroenterology (1994) [Pubmed]
  3. Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. De Berardinis, V., Moulis, C., Maurice, M., Beaune, P., Pessayre, D., Pompon, D., Loeper, J. Mol. Pharmacol. (2000) [Pubmed]
  4. Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse. Kouzi, S.A., McMurtry, R.J., Nelson, S.D. Chem. Res. Toxicol. (1994) [Pubmed]
  5. Determination of Teucrium chamaedrys volatiles by using direct thermal desorption-comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Ozel, M.Z., Göğüş, F., Lewis, A.C. Journal of chromatography. A. (2006) [Pubmed]
  6. Herbal bioactivation: the good, the bad and the ugly. Zhou, S., Koh, H.L., Gao, Y., Gong, Z.Y., Lee, E.J. Life Sci. (2004) [Pubmed]
  7. Teucrol, a decarboxyrosmarinic acid and its 4'-O-triglycoside, teucroside from Teucrium pilosum. El-Mousallamy, A.M., Hawas, U.W., Hussein, S.A. Phytochemistry (2000) [Pubmed]
  8. Analysis of Scutellaria lateriflora and its adulterants Teucrium canadense and Teucrium chamaedrys by LC-UV/MS, TLC, and digital photomicroscopy. Gafner, S., Bergeron, C., Batcha, L.L., Angerhofer, C.K., Sudberg, S., Sudberg, E.M., Guinaudeau, H., Gauthier, R. Journal of AOAC International. (2003) [Pubmed]
  9. 6-Hydroxyluteolin-7-O-(1''-alpha-rhamnoside) from Vriesea sanguinolenta Cogn. and Marchal (Bromeliaceae). Bringmann, G., Ochse, M., Zotz, G., Peters, K., Peters, E.M., Brun, R., Schlauer, J. Phytochemistry (2000) [Pubmed]
  10. In vitro antioxidant activity of some Teucrium species (Lamiaceae). Kadifkova Panovska, T., Kulevanova, S., Stefova, M. Acta pharmaceutica (Zagreb, Croatia) (2005) [Pubmed]
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