Disease relevance of Polygonatum

• The anti-human immunodeficiency virus (HIV) I/II activity of a mannose and sialic acid binding lectin isolated from rhizomes of Polygonatum cyrtonema Hua was elucidated by comparing its HIV infection inhibitory activity in MT-4 and CEM cells with that of other mannose-binding lectins (MBLs) [1].

High impact information on Polygonatum

• The most prominent protein of Polygonatum multiflorum (common Solomon's seal) rhizomes has been identified as a mannose-binding lectin [2].
• The hypoglycemic effect of the rhizomes of Polygonatum officinale (Liliaceae) was investigated in both normal and streptozotocin-induced diabetic mice [3].
• Structure of polysaccharide from Polygonatum cyrtonema Hua and the antiherpetic activity of its hydrolyzed fragments [4].
• Steroid glycosides from Polygonatum prattii [5].
• Investigation of the rhizomes of Polygonatum sibiricum led to the isolation of the previously reported neoprazerigenin A 3-O-beta-lycotetraoside [3], its methyl proto-type congener 2, and two new steroidal saponins, sibiricosides A [1] and B [4] [6].

Anatomical context of Polygonatum

• Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells [7].

Associations of Polygonatum with chemical compounds

• (Solomon's seal) contain besides a monocot mannose-binding lectin two galactose/N-acetylgalactosamine (Gal/GalNAc)-binding type 2 ribosome-inactivating proteins (RIPs) [8].
• Rabbits were given a high-cholesterol (0.5%, wt/wt) diet with vitamin E (0.03%, wt/wt) or a Polygonatum extract (0.05%, wt/wt) for 8 weeks [9].
• Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua [1].
• Hepatic total glutathione content was significantly higher in the Polygonatum group than in the other groups [9].
• The methanol extract of the rhizomes of both Polygonatum sibricum (OM) and Polygonatum officinale (IM) (800 mg/kg) reduced the blood glucose levels in KK-Ay mice 4h after intraperitoneal administration [10].

Gene context of Polygonatum

• Two saponins, methyl protodioscin and dioscin, were extracted from the root of Polygonatum Zanlanscianense Pamp [7].
• The hypoglycemic effect of the rhizomes of Polygonatum sibricum and Polygonatum officinale (Liliaceae) was investigated in KK-Ay mice, one of the animal models of non-insulin dependent diabetes mellitus (NIDDM) [10].

Analytical, diagnostic and therapeutic context of Polygonatum

• Meanwhile, the plasma vitamin E concentration was significantly higher in the vitamin E and Polygonatum groups than in the control group; however, plasma vitamin A concentration did not differ significantly between the groups [9].

References