The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Peptide Biosynthesis

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Peptide Biosynthesis


Biological context of Peptide Biosynthesis


Associations of Peptide Biosynthesis with chemical compounds


Gene context of Peptide Biosynthesis

  • The results suggest that excitatory amino acid transmission mediated by the NMDA receptor serves as a tonic signal to stimulate neuroactive peptide biosynthesis [13].
  • A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis [14].
  • PAM catalyzes the final step in alpha-amidated peptide biosynthesis, and its proposed role in primary fatty acid amide biosynthesis has been controversial [15].
  • The unique biosynthetic and enzymic patterns seen for PACE4 suggest a role for this neuroendocrine-specific subtilisin-like endoprotease outside the pathway for peptide biosynthesis [16].
  • These results suggest that the decreases in hypothalamic POMC peptide levels after E administration reported previously may be due to a decrease in POMC peptide biosynthesis resulting from a decrease in hypothalamic POMC mRNA [17].

Analytical, diagnostic and therapeutic context of Peptide Biosynthesis


  1. Nicotinic receptor stimulation activates enkephalin release and biosynthesis in adrenal chromaffin cells. Eiden, L.E., Giraud, P., Dave, J.R., Hotchkiss, A.J., Affolter, H.U. Nature (1984) [Pubmed]
  2. Cycloheximide-sensitive synthesis of substance P by isolated dorsal root ganglia. Harmar, A., Schofield, J.G., Keen, P. Nature (1980) [Pubmed]
  3. Carboxypeptidase E. Fricker, L.D. Annu. Rev. Physiol. (1988) [Pubmed]
  4. Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses. Paquet, L., Massie, B., Mains, R.E. J. Neurosci. (1996) [Pubmed]
  5. Regulation of synthesis of the neurosecretory egg-laying hormone of Aplysia: antagonistic roles of calcium and cyclic adenosine 3':5'-monophosphate. Bruehl, C.L., Berry, R.W. J. Neurosci. (1985) [Pubmed]
  6. Glucocorticoid regulation of enkephalins in cultured rat adrenal medulla. Inturrisi, C.E., Branch, A.D., Robertson, H.D., Howells, R.D., Franklin, S.O., Shapiro, J.R., Calvano, S.E., Yoburn, B.C. Mol. Endocrinol. (1988) [Pubmed]
  7. Regulation of cyclic peptide biosynthesis and pathogenicity in Cochliobolus carbonum by TOXEp, a novel protein with a bZIP basic DNA-binding motif and four ankyrin repeats. Ahn, J.H., Walton, J.D. Mol. Gen. Genet. (1998) [Pubmed]
  8. Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway. MacCabe, A.P., van Liempt, H., Palissa, H., Unkles, S.E., Riach, M.B., Pfeifer, E., von Döhren, H., Kinghorn, J.R. J. Biol. Chem. (1991) [Pubmed]
  9. Stimulation by D-glucose of protein biosynthesis in tumoral insulin-producing cells (RINm5F line). Valverde, I., Barreto, M., Malaisse, W.J. Endocrinology (1988) [Pubmed]
  10. Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures. Brubaker, P.L. Endocrinology (1988) [Pubmed]
  11. Examination of the rate of peptide biosynthesis in neuroendocrine cell lines using a stable isotopic label and mass spectrometry. Che, F.Y., Yuan, Q., Kalinina, E., Fricker, L.D. J. Neurochem. (2004) [Pubmed]
  12. Potential drug targets for Mycobacterium avium defined by radiometric drug-inhibitor combination techniques. Rastogi, N., Goh, K.S., Wright, E.L., Barrow, W.W. Antimicrob. Agents Chemother. (1994) [Pubmed]
  13. N-methyl-D-aspartate receptor antagonism alters substance P and met5-enkephalin biosynthesis in neurons of the rat striatum. Somers, D.L., Beckstead, R.M. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  14. A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis. Cheng, Y.Q., Walton, J.D. J. Biol. Chem. (2000) [Pubmed]
  15. Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. Merkler, D.J., Chew, G.H., Gee, A.J., Merkler, K.A., Sorondo, J.P., Johnson, M.E. Biochemistry (2004) [Pubmed]
  16. PACE4: a subtilisin-like endoprotease with unique properties. Mains, R.E., Berard, C.A., Denault, J.B., Zhou, A., Johnson, R.C., Leduc, R. Biochem. J. (1997) [Pubmed]
  17. Estrogen decreases rat hypothalamic proopiomelanocortin messenger ribonucleic acid levels. Wilcox, J.N., Roberts, J.L. Endocrinology (1985) [Pubmed]
  18. The modular organization of multifunctional peptide synthetases. Vater, J., Stein, T., Vollenbroich, D., Kruft, V., Wittmann-Liebold, B., Franke, P., Liu, L., Zuber, P. J. Protein Chem. (1997) [Pubmed]
WikiGenes - Universities