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MeSH Review

Food Contamination

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Disease relevance of Food Contamination


High impact information on Food Contamination

  • The mycotoxin aflatoxin B1 (AFB1) is considered to be a major causative agent in hepatocellular carcinoma (HCC) in regions with presumed high food contamination by AFB1 [2].
  • Although differences in analytic methods and participant ages limit comparability, toxicant levels from the Mohawk youth are lower than those associated with severe food contamination (Yusho and Yu-cheng) but similar to other chronically exposed groups [3].
  • Because indoor fluoride from combustion of coal is easily absorbed in stored food and because food consumption is a main source of fluoride exposure, it is necessary to reduce airborne fluoride and food contamination to prevent serious fluorosis in China [4].
  • Cadmium was sixfold more toxic for snails exposed via food contamination (median effective concentration [EC50], 68-139 microg/g) than via soil contamination (EC50, 534-877 microg/g), whereas the opposite occurred with the sewage sludge (EC50, 55% of sludge in the food and 10% of waste in the soil) [5].
  • A controversial discussion is going on if thujone, a characteristic component of the essential oil of the wormwood plant Artemisia absinthium L., is responsible for absinthism, or if it was merely caused by chronic alcohol intoxication or by other reasons such as food adulterations [6].

Biological context of Food Contamination


Associations of Food Contamination with chemical compounds


Gene context of Food Contamination

  • Although organochlorine pesticides such as DDT and HCH have been banned in China since 1983, the residues of such compounds still exist in the environment and cause food contamination, a fact likely attributed to the short prohibition period and illegal use for agricultural purposes at present [13].


  1. p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan. Nose, H., Imazeki, F., Ohto, M., Omata, M. Cancer (1993) [Pubmed]
  2. The p53 codon 249 mutational hotspot in hepatocellular carcinoma is not related to selective formation or persistence of aflatoxin B1 adducts. Denissenko, M.F., Koudriakova, T.B., Smith, L., O'Connor, T.R., Riggs, A.D., Pfeifer, G.P. Oncogene (1998) [Pubmed]
  3. Organochlorines, lead, and mercury in Akwesasne Mohawk youth. Schell, L.M., Hubicki, L.A., DeCaprio, A.P., Gallo, M.V., Ravenscroft, J., Tarbell, A., Jacobs, A., David, D., Worswick, P. Environ. Health Perspect. (2003) [Pubmed]
  4. Health effects of indoor fluoride pollution from coal burning in China. Ando, M., Tadano, M., Asanuma, S., Tamura, K., Matsushima, S., Watanabe, T., Kondo, T., Sakurai, S., Ji, R., Liang, C., Cao, S. Environ. Health Perspect. (1998) [Pubmed]
  5. How terrestrial snails can be used in risk assessment of soils. de Vaufleury, A., Coeurdassier, M., Pandard, P., Scheifler, R., Lovy, C., Crini, N., Badot, P.M. Environ. Toxicol. Chem. (2006) [Pubmed]
  6. Thujone--cause of absinthism? Lachenmeier, D.W., Emmert, J., Kuballa, T., Sartor, G. Forensic Sci. Int. (2006) [Pubmed]
  7. Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode. Vrijens, B., De Henauw, S., Dewettinck, K., Talloen, W., Goeyens, L., De Backer, G., Willems, J.L. Food additives and contaminants. (2002) [Pubmed]
  8. The possibility of food contamination with cadmium by means of coloured plastics. Preda, N., Popa, L., Ariesan, M. Journal of applied toxicology : JAT. (1983) [Pubmed]
  9. Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia. Maaroufi, K., Achour, A., Betbeder, A.M., Hammami, M., Ellouz, F., Creppy, E.E., Bacha, H. Arch. Toxicol. (1995) [Pubmed]
  10. Implications of the use of semicarbazide as a metabolic target of nitrofurazone contamination in coated products. Pereira, A.S., Donato, J.L., De Nucci, G. Food additives and contaminants. (2004) [Pubmed]
  11. Organochlorine pesticide and polychlorinated biphenyl residues in foodstuffs from Bangkok, Thailand. Tanabe, S., Kannan, K., Tabucanon, M.S., Siriwong, C., Ambe, Y., Tatsukawa, R. Environ. Pollut. (1991) [Pubmed]
  12. Estimation of menthol in Pan Masala samples by a spectrophotometric method. Kannan, A., Das, M., Khanna, S.K. Food additives and contaminants. (1997) [Pubmed]
  13. 2001 survey of organochlorine pesticides in retail milk from Beijing, P R China. Zhong, W., Xu, D., Chai, Z., Mao, X. Food additives and contaminants. (2003) [Pubmed]
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