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MKX  -  mohawk homeobox

Homo sapiens

Synonyms: C10orf48, Homeobox protein Mohawk, IFRX, IRXL1, MGC39616
 
 
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Disease relevance of MKX

 

Psychiatry related information on MKX

 

High impact information on MKX

  • Lawrence River. At the Mohawk Nation at Akwesasne (in New York and in Ontario and Quebec, Canada), 103 adults were interviewed, and they donated blood for serum PCB analysis and underwent the caffeine breath test (CBT), a safe and noninvasive procedure that uses caffeine as a probe for CYP1A2 activity in vivo [8].
  • Although differences in analytic methods and participant ages limit comparability, toxicant levels from the Mohawk youth are lower than those associated with severe food contamination (Yusho and Yu-cheng) but similar to other chronically exposed groups [9].
  • Fish consumption and breast milk PCB concentrations among Mohawk women at Akwesasne [10].
  • Energy expenditure and body fat distribution in Mohawk children [1].
  • Total energy expenditure was significantly higher in Mohawk children compared to Caucasian (100 kcal/day in girls, 150 kcal/day in boys), independent of fat free mass and sex, due to a significantly higher physical activity-related energy expenditure [1].
 

Biological context of MKX

  • In addition, approximately one third of all available EST sequences were obtained from embryonic tissues, suggesting that IFRX has a role in embryonic development [11].
  • The corresponding IFRX gene was located on chromosome 10p12.1 and is organized in seven exons [11].
  • The major purpose of the current project is to determine if there are associations between dietary, residential, and occupational exposures to PCBs and DDE and individual body burdens in Mohawk men, specifically the husbands, partners, fathers, brothers, or other male relatives of the women in our other studies [12].
  • Correlates and predictors of adiposity among Mohawk children [13].
  • From 1986 to 1992, 97 Mohawk women were interviewed within one month postpartum [14].
 

Anatomical context of MKX

 

Associations of MKX with chemical compounds

  • The association between local fish consumption and DDE, mirex, and HCB concentrations in the breast milk of Mohawk women at Akwesasne [16].
  • Neurobehavioral assessment of Mohawk Indians for subclinical indications of methyl mercury neurotoxicity [17].
  • Organochlorine pesticides, PCBs, dibenzodioxin, and furan concentrations in common snapping turtle eggs (Chelydra serpentina serpentina) in Akwesasne, Mohawk Territory, Ontario, Canada [18].
  • The diet of Mohawk children (grades 4 through 6) was assessed using 24-hour recalls after 4 years' participation in the Kahnawake Schools Diabetes Prevention Project. Analysis compared mean intakes of energy, fat, and sucrose, and proportions of children consuming each food [19].
  • Long-term trends in sodium and chloride in the Mohawk River, New York: the effect of fifty years of road-salt application [20].
 

Analytical, diagnostic and therapeutic context of MKX

  • After adjustment for potential confounders, Mohawk mothers who gave birth in 1986-1989 had a geometric mean milk total PCB concentration of 0.602 ppm (fat basis) compared with 0.375 ppm for the control group (p = 0.009) [10].
  • Chest skinfold thickness, the ratio of trunk skinfolds:extremity skinfolds, and the waist:hip ratio were significantly higher in Mohawk children by 2.5 mm, 0.09 units, and 0.03 units, respectively, independent of sex and fat mass [1].
  • Distribution of albumin variants Naskapi amd Mexico among Aleuts, Frobisher Bay Eskimos, and Micmac, Naskapi, Mohawk, Omaha, and Apache Indians [21].
  • RESULTS: Compared with children studied in NHANES II, Mohawk children were similar in height and triceps skinfolds but were generally heavier, had thicker subscapular skinfolds, and had greater waist and hip circumferences [4].
  • DESIGN: This is a cross-sectional study comparing distributions of anthropometric characteristics of Mohawk children to the corresponding age and gender data from the Second National Health and Nutrition Examination Survey (NHANES II) [4].

References

  1. Energy expenditure and body fat distribution in Mohawk children. Goran, M.I., Kaskoun, M., Johnson, R., Martinez, C., Kelly, B., Hood, V. Pediatrics (1995) [Pubmed]
  2. Determinants of resting energy expenditure in young children. Goran, M.I., Kaskoun, M., Johnson, R. J. Pediatr. (1994) [Pubmed]
  3. Diabetes mellitus and atherosclerosis: returning research results to the Mohawk community. Montour, L.T., Macaulay, A.C. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (1988) [Pubmed]
  4. Anthropometric characteristics of Mohawk children aged 6 to 11 years: a population perspective. Potvin, L., Desrosiers, S., Trifonopoulos, M., Leduc, N., Rivard, M., Macaulay, A.C., Paradis, G. Journal of the American Dietetic Association. (1999) [Pubmed]
  5. The Kahnawake Schools Diabetes Prevention Project: intervention, evaluation, and baseline results of a diabetes primary prevention program with a native community in Canada. Macaulay, A.C., Paradis, G., Potvin, L., Cross, E.J., Saad-Haddad, C., McComber, A., Desrosiers, S., Kirby, R., Montour, L.T., Lamping, D.L., Leduc, N., Rivard, M. Preventive medicine. (1997) [Pubmed]
  6. Food preferences predict eating behavior of very young Mohawk children. Harvey-Berino, J., Hood, V., Rourke, J., Terrance, T., Dorwaldt, A., Secker-Walker, R. Journal of the American Dietetic Association. (1997) [Pubmed]
  7. Community governance of the Kahnawake Schools Diabetes Prevention Project, Kahnawake Territory, Mohawk Nation, Canada. Cargo, M., Lévesque, L., Macaulay, A.C., McComber, A., Desrosiers, S., Delormier, T., Potvin, L. Health promotion international. (2003) [Pubmed]
  8. PCB exposure and in vivo CYP1A2 activity among Native Americans. Fitzgerald, E.F., Hwang, S.A., Lambert, G., Gomez, M., Tarbell, A. Environ. Health Perspect. (2005) [Pubmed]
  9. Organochlorines, lead, and mercury in Akwesasne Mohawk youth. Schell, L.M., Hubicki, L.A., DeCaprio, A.P., Gallo, M.V., Ravenscroft, J., Tarbell, A., Jacobs, A., David, D., Worswick, P. Environ. Health Perspect. (2003) [Pubmed]
  10. Fish consumption and breast milk PCB concentrations among Mohawk women at Akwesasne. Fitzgerald, E.F., Hwang, S.A., Bush, B., Cook, K., Worswick, P. Am. J. Epidemiol. (1998) [Pubmed]
  11. In silico characterization of an Iroquois family-related homeodomain protein. Weinmann, A., Galle, P.R., Teufel, A. Int. J. Mol. Med. (2005) [Pubmed]
  12. Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) exposure among Native American men from contaminated Great Lakes fish and wildlife. Fitzgerald, E.F., Brix, K.A., Deres, D.A., Hwang, S.A., Bush, B., Lambert, G., Tarbell, A. Toxicology and industrial health. (1996) [Pubmed]
  13. Correlates and predictors of adiposity among Mohawk children. Horn, O.K., Paradis, G., Potvin, L., Macaulay, A.C., Desrosiers, S. Preventive medicine. (2001) [Pubmed]
  14. Fish PCB concentrations and consumption patterns among Mohawk women at Akwesasne. Fitzgerald, E.F., Hwang, S.A., Brix, K.A., Bush, B., Cook, K., Worswick, P. Journal of exposure analysis and environmental epidemiology. (1995) [Pubmed]
  15. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Takeuchi, J.K., Bruneau, B.G. Gene Expr. Patterns (2007) [Pubmed]
  16. The association between local fish consumption and DDE, mirex, and HCB concentrations in the breast milk of Mohawk women at Akwesasne. Fitzgerald, E.F., Hwang, S.A., Deres, D.A., Bush, B., Cook, K., Worswick, P. Journal of exposure analysis and environmental epidemiology. (2001) [Pubmed]
  17. Neurobehavioral assessment of Mohawk Indians for subclinical indications of methyl mercury neurotoxicity. Valciukas, J.A., Levin, S.M., Nicholson, W.J., Selikoff, I.J. Arch. Environ. Health (1986) [Pubmed]
  18. Organochlorine pesticides, PCBs, dibenzodioxin, and furan concentrations in common snapping turtle eggs (Chelydra serpentina serpentina) in Akwesasne, Mohawk Territory, Ontario, Canada. de Solla, S.R., Bishop, C.A., Lickers, H., Jock, K. Arch. Environ. Contam. Toxicol. (2001) [Pubmed]
  19. Comparison of the dietary intakes of two different groups of children (grades 4 to 6) before and after the Kahnawake Schools Diabetes Prevention Project. Jimenez, M.M., Receveur, O., Trifonopoulos, M., Kuhnlein, H., Paradis, G., Macaulay, A.C. Journal of the American Dietetic Association. (2003) [Pubmed]
  20. Long-term trends in sodium and chloride in the Mohawk River, New York: the effect of fifty years of road-salt application. Godwin, K.S., Hafner, S.D., Buff, M.F. Environ. Pollut. (2003) [Pubmed]
  21. Distribution of albumin variants Naskapi amd Mexico among Aleuts, Frobisher Bay Eskimos, and Micmac, Naskapi, Mohawk, Omaha, and Apache Indians. Schell, L.M., Agarwal, S.S., Blumberg, B.S., Levy, H., Bennett, P.H., Laughlin, W.S., Martin, J.P. Am. J. Phys. Anthropol. (1978) [Pubmed]
 
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