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MeSH Review:

Cytotoxicity Tests, Immunologic

Warnatz, H. et al., Mariani, E. et al., Urtasun, R.C. et al., Liu, H.C., Akiyama, N. et al., et al.

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Disease relevance of Cytotoxicity Tests, Immunologic

Spleen cells from rabbits affected by adriamycin-induced cardiomyopathy were specifically cytotoxic for rabbit embryonic heart cells in microcytotoxicity tests [1].
This study investigated whether peripheral blood mononuclear cells from normal healthy donors could be activated by interleukin (IL)-12 and IL-2, separately or in combination, to lyse osteosarcoma cell lines in vitro, as evaluated by using a microcytotoxicity test [2].
Sarcoma - lymphocyte-mediated cytotoxicity and serum blocking of this activity was studied by the in vitro microcytotoxicity test in three patients with osteogenic sarcoma who received preoperative irradiation [3].
Cytotoxic reactivity of lymphocytes from RA patients, osteoarthrosis patients or healthy controls to synovial cells of autologous or allogeneic origin could not be demonstrated in our study, in which 125I-iododeoxyuridine labelled target cells were used in the microcytotoxicity test of Cohen et al [4].

High impact information on Cytotoxicity Tests, Immunologic

Cell-mediated cytotoxicity against SRBC was assayed by a microcytotoxicity test with sheep fibroblasts as target cells [5].
Some of anti-HLA sera were inhibitory for the Fc-rosette formation, while the tested sera did not contain anti-HLA activity assessed by the microcytotoxicity test [6].
We developed an improved method for the dye-exclusion microcytotoxicity test by introducing low melting point agarose (LMP-Aga) into the assay medium [7].
Fourteen BoLA specificities were detected in the herd using a standard lymphocyte microcytotoxicity test [8].
Using the two-step microcytotoxicity test as recommended by NIH, U.S.A., 66 Chinese of definite ankylosing spondylitis (AS), 41 their first-degree relatives, and 43 normal Chinese received HLA analysis [9].

Analytical, diagnostic and therapeutic context of Cytotoxicity Tests, Immunologic

In order to examine the presence of antibodies against B cells, 83 sera obtained from 55 renal transplant recipients were screened by microcytotoxicity test using Daudi cell line [10].

References

Autoantibodies and spleen cell-mediated cytotoxicity in adriamycin-induced myocardiopathy in rabbits. Fioretti, A., Ghione, M., Pozzoli, E., Lambertenghi-Deliliers, G. Cancer Res. (1976) [Pubmed]
Interleukin-12 induces efficient lysis of natural killer-sensitive and natural killer-resistant human osteosarcoma cells: the synergistic effect of interleukin-2. Mariani, E., Meneghetti, A., Tarozzi, A., Cattini, L., Facchini, A. Scand. J. Immunol. (2000) [Pubmed]
Disapperance of osteogenic sarcoma after irradiation: immunologic observations. Urtasun, R.C., Connachie, P.R. Journal of the Canadian Association of Radiologists. (1976) [Pubmed]
In vitro studies on lymphocytotoxicity to synovial cells and Chang cells in rheumatoid arthritis patients and healthy controls. Warnatz, H., Thommes, M. Zeitschrift für Rheumatologie. (1979) [Pubmed]
Rosette-forming ability of thymus-derived lymphocytes in cell-mediated immunity. I. Delayed hypersensitivity and in vitro cytotoxicity. Elliott, B.E., Haskill, J.S., Axelrad, M.A. J. Exp. Med. (1975) [Pubmed]
Fc-rosette inhibition by hypocomplementaemic systemic lupus erythematosus sera. Morito, T., Tanimoto, K., Hashimoto, Y., Horiuchi, Y., Juji, T. Ann. Rheum. Dis. (1975) [Pubmed]
Further improvement of dye-exclusion microcytotoxicity assay by introducing low melting point agarose into the medium. Kubota, E., Ishikawa, H., Saito, K. J. Immunol. Methods (1983) [Pubmed]
Preliminary report on BoLA polymorphism in Guernsey cattle. Nonnecke, B.J., Lewin, H.A., Timms, L.L. J. Dairy Sci. (1989) [Pubmed]
Histocompatibility profile in Chinese with ankylosing spondylitis. Liu, H.C. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1981) [Pubmed]
Screening of anti-B cell antibodies in the sera of renal transplant recipients by using Daudi cell line. Akiyama, N., Mori, T., Kusaba, R., Inou, T., Hamajima, K. Jpn. J. Exp. Med. (1978) [Pubmed]

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