The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Esr2  -  estrogen receptor 2 (beta)

Mus musculus

Synonyms: ER beta, ER-beta, ER[b], ERbeta, Estrb, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Esr2


Psychiatry related information on Esr2


High impact information on Esr2


Chemical compound and disease context of Esr2


Biological context of Esr2


Anatomical context of Esr2

  • The contribution of the hematopoietic and nonhematopoietic cellular compartments associated with the heterotic effect at Esr2 in regulating the severity of clinical EAE was identified using reciprocal hematopoietic radiation bone marrow chimeras generated between male wild-type and Esr2(+/-) mice [1].
  • These findings reveal an important role for ERbeta in response to E(2) and in the organization, growth, and differentiation of the uterine epithelium [20].
  • In both untreated and E(2)-treated mice, ERalpha and ERbeta were colocalized in the nuclei of many stromal and glandular epithelial cells [20].
  • In ERbeta(-/-) mice, there was a marked expression of EGFR in the nuclei of epithelial and stromal cells [20].
  • Upon E(2) treatment, EGFR on cell membranes was down-regulated in WT but not in ERbeta(-/-) mice [20].

Associations of Esr2 with chemical compounds


Regulatory relationships of Esr2


Other interactions of Esr2


Analytical, diagnostic and therapeutic context of Esr2


  1. Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Polanczyk, M., Yellayi, S., Zamora, A., Subramanian, S., Tovey, M., Vandenbark, A.A., Offner, H., Zachary, J.F., Fillmore, P.D., Blankenhorn, E.P., Gustafsson, J.A., Teuscher, C. Am. J. Pathol. (2004) [Pubmed]
  2. Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Morani, A., Barros, R.P., Imamov, O., Hultenby, K., Arner, A., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Cvoro, A., Paruthiyil, S., Jones, J.O., Tzagarakis-Foster, C., Clegg, N.J., Tatomer, D., Medina, R.T., Tagliaferri, M., Schaufele, F., Scanlan, T.S., Diamond, M.I., Cohen, I., Leitman, D.C. Endocrinology (2007) [Pubmed]
  4. Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. Carswell, H.V., Macrae, I.M., Gallagher, L., Harrop, E., Horsburgh, K.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  5. Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis. Imamov, O., Yakimchuk, K., Morani, A., Schwend, T., Wada-Hiraike, O., Razumov, S., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Tiwari-Woodruff, S., Morales, L.B., Lee, R., Voskuhl, R.R. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  7. Involvement of estrogen receptor alpha, beta and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice. Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J.A., Korach, K.S., Muglia, L.J., Pfaff, D.W. Genes Brain Behav. (2006) [Pubmed]
  8. Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Förster, C., Mäkela, S., Wärri, A., Kietz, S., Becker, D., Hultenby, K., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Morphological abnormalities in the brains of estrogen receptor beta knockout mice. Wang, L., Andersson, S., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Ogawa, S., Chan, J., Gustafsson, J.A., Korach, K.S., Pfaff, D.W. Endocrinology (2003) [Pubmed]
  11. Distribution of estrogen receptor beta (ERbeta) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement. Gundlah, C., Kohama, S.G., Mirkes, S.J., Garyfallou, V.T., Urbanski, H.F., Bethea, C.L. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  12. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Paech, K., Webb, P., Kuiper, G.G., Nilsson, S., Gustafsson, J., Kushner, P.J., Scanlan, T.S. Science (1997) [Pubmed]
  13. Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. Tremblay, A., Tremblay, G.B., Labrie, F., Giguère, V. Mol. Cell (1999) [Pubmed]
  14. New roles for estrogen receptor beta in behavior and neuroendocrinology. Bodo, C., Rissman, E.F. Frontiers in neuroendocrinology. (2006) [Pubmed]
  15. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Dubal, D.B., Zhu, H., Yu, J., Rau, S.W., Shughrue, P.J., Merchenthaler, I., Kindy, M.S., Wise, P.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  16. Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro. Lambert, K.C., Curran, E.M., Judy, B.M., Lubahn, D.B., Estes, D.M. J. Leukoc. Biol. (2004) [Pubmed]
  17. Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. McPherson, S.J., Ellem, S.J., Simpson, E.R., Patchev, V., Fritzemeier, K.H., Risbridger, G.P. Endocrinology (2007) [Pubmed]
  18. Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta). Naaz, A., Zakroczymski, M., Heine, P., Taylor, J., Saunders, P., Lubahn, D., Cooke, P.S. Horm. Metab. Res. (2002) [Pubmed]
  19. Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Risbridger, G., Wang, H., Young, P., Kurita, T., Wang, Y.Z., Lubahn, D., Gustafsson, J.A., Cunha, G., Wong, Y.Z. Dev. Biol. (2001) [Pubmed]
  20. Role of estrogen receptor beta in uterine stroma and epithelium: Insights from estrogen receptor beta-/- mice. Wada-Hiraike, O., Hiraike, H., Okinaga, H., Imamov, O., Barros, R.P., Morani, A., Omoto, Y., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  21. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Tremblay, G.B., Tremblay, A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Labrie, F., Giguère, V. Mol. Endocrinol. (1997) [Pubmed]
  22. Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice. Lindzey, J., Wetsel, W.C., Couse, J.F., Stoker, T., Cooper, R., Korach, K.S. Endocrinology (1998) [Pubmed]
  23. Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice. Mueller, S.O., Katzenellenbogen, J.A., Korach, K.S. Steroids (2004) [Pubmed]
  24. Sex specific expression of progesterone receptor in mouse lower urinary tract. Savolainen, S., Santti, R., Streng, T., Gustafsson, J.A., Härkönen, P., Mäkelä, S. Mol. Cell. Endocrinol. (2005) [Pubmed]
  25. Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe. Gundlah, C., Alves, S.E., Clark, J.A., Pai, L.Y., Schaeffer, J.M., Rohrer, S.P. Biol. Psychiatry (2005) [Pubmed]
  26. Estrogen activation of cyclic adenosine 5'-monophosphate response element-mediated transcription requires the extracellularly regulated kinase/mitogen-activated protein kinase pathway. Wade, C.B., Dorsa, D.M. Endocrinology (2003) [Pubmed]
  27. Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse. Dorling, A.A., Todman, M.G., Korach, K.S., Herbison, A.E. Neuroendocrinology (2003) [Pubmed]
  28. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Ogawa, S., Chan, J., Chester, A.E., Gustafsson, J.A., Korach, K.S., Pfaff, D.W. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  29. Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse. Kurita, T., Lee, K., Saunders, P.T., Cooke, P.S., Taylor, J.A., Lubahn, D.B., Zhao, C., Mäkelä, S., Gustafsson, J.A., Dahiya, R., Cunha, G.R. Biol. Reprod. (2001) [Pubmed]
  30. Oxytocin, but not oxytocin receptor, is rRegulated by oestrogen receptor beta in the female mouse hypothalamus. Patisaul, H.B., Scordalakes, E.M., Young, L.J., Rissman, E.F. J. Neuroendocrinol. (2003) [Pubmed]
  31. A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary. Cheng, G., Weihua, Z., Mäkinen, S., Mäkelä, S., Saji, S., Warner, M., Gustafsson, J.A., Hovatta, O. Biol. Reprod. (2002) [Pubmed]
  32. Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area. Kudwa, A.E., Gustafsson, J.A., Rissman, E.F. Endocrinology (2004) [Pubmed]
  33. The distribution of estrogen receptor-beta mRNA in forebrain regions of the estrogen receptor-alpha knockout mouse. Shughrue, P., Scrimo, P., Lane, M., Askew, R., Merchenthaler, I. Endocrinology (1997) [Pubmed]
  34. Biologically active estrogen receptor-beta: evidence from in vivo autoradiographic studies with estrogen receptor alpha-knockout mice. Shughrue, P.J., Lane, M.V., Merchenthaler, I. Endocrinology (1999) [Pubmed]
  35. Estrogen receptor knockout mice as a model for endocrine research. Walker, V.R., Korach, K.S. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. (2004) [Pubmed]
WikiGenes - Universities