The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DRD1  -  dopamine receptor D1

Homo sapiens

Synonyms: D(1A) dopamine receptor, DADR, DRD1A, Dopamine D1 receptor


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.


Disease relevance of DRD1

  • RESULTS: Results of chi-square statistical analyses indicated that the allele distribution for migraine cases compared to controls was not significantly different for any of the three tested gene markers (chi2 = 0.1, P =.74 for DRD1; chi2 = 1.8, P =.18 for DRD3; and chi2 = 20.3, P =.08 for DRD5) [1].
  • Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension [2].
  • We report here the effect of maternal age and the age of the mother at the birth of her first child (maternal age 1st) as epistatic factors for the interaction of the dopamine D1 gene (DRD1) with obsessive-compulsive behaviors and with stuttering [3].
  • RESULTS: The polymorphisms of the dopamine receptor D1 gene were not associated with the risk of developing PD or peak-dose dyskinesias [4].

Psychiatry related information on DRD1


High impact information on DRD1


Biological context of DRD1

  • CONCLUSIONS: Genetic variation in DRD1 and DRD3 genes may act to modify the course of AD, predisposing to the development of psychotic or aggressive symptoms [11].
  • RESULTS: Among white patients, psychosis and aggression were both significantly more frequent in DRD1 B2/B2 homozygotes (P < .02), while psychosis was significantly more frequent in DRD3 1/1 or 2/2 homozygotes (P < .05) [11].
  • No behavioral, cognitive, or brain MRI volume measurement significantly differed across NET1 or DRD1 genotypes at an alpha of 0.01 [12].
  • To search for such a variant we screened the DRD1 coding region, by sequencing, focusing on the children who showed preferential transmission of Haplotype 3 [13].
  • We identified a cosmid clone with exact sequence homology to part of the human dopamine D5 receptor gene (DRD5) after screening a cosmid library with the human DRD1 gene [14].

Associations of DRD1 with chemical compounds

  • Two of these dopamine receptors (DRD1 and DRD5) are encoded by intronless genes [15].
  • The results for both the DRD1 and DRD2 genes, which have opposing effects on cyclic AMP, were consistent with negative and positive heterosis, respectively [8].
  • The purpose of the present study was to evaluate the association of DRD1 A-48G polymorphism with methamphetamine (MAP) abusers and MAP-induced psychosis patients [16].
  • Our preliminary analysis demonstrated that the 14-3-3 epsilon gene, which mediate signal transduction by binding to phosphoserine-containing proteins is not associated with suicide attempt in schizophrenia, however the BspI polymorphism in DRD1 gene showed a slight association with suicide attempt in the bipolar sample [17].
  • The effects of the dopamine receptor D1 partial agonist, SKF 38393, on behavior maintained by cocaine was assessed in squirrel monkeys (Saimiri sciureus) [18].

Physical interactions of DRD1

  • A significant association was observed between a DRD2 allele and AFSI and an even stronger association when the DRD2 allele was interacted with a DRD1 allele [19].

Other interactions of DRD1

  • DRD1 is primarily implicated through mouse models of ADHD [12].
  • Apomorphine-induced growth hormone release did not differ significantly in alcoholics with different genotypes of the DRD1 and DRD2 RFLPs [20].
  • A polymerase chain reaction was used to identify the A/G polymorphism of the DRD1 gene [21].
  • Therefore, we investigated whether the A-48G polymorphism of the DRD1 gene and the T393C polymorphism of the Gs protein alpha subunit (GNAS) gene influenced BP levels at rest and in response to stress [22].
  • However, no correlation was observed between DRD1/DRD2 expression and DARPP-32 expression (P = 0.4555 and 0.4774, respectively) [23].

Analytical, diagnostic and therapeutic context of DRD1


  1. Dopamine receptor genes and migraine with and without aura: an association study. Shepherd, A.G., Lea, R.A., Hutchins, C., Jordan, K.L., Brimage, P.J., Griffiths, L.R. Headache. (2002) [Pubmed]
  2. Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension. Beige, J., Bellmann, A., Sharma, A.M., Gessner, R. Am. J. Hypertens. (2004) [Pubmed]
  3. Maternal age at the birth of the first child as an epistatic factor in polygenic disorders. Comings, D.E., MacMurray, J.P. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006) [Pubmed]
  4. Dopamine D2 receptor gene polymorphism and the risk of levodopa-induced dyskinesias in PD. Oliveri, R.L., Annesi, G., Zappia, M., Civitelli, D., Montesanti, R., Branca, D., Nicoletti, G., Spadafora, P., Pasqua, A.A., Cittadella, R., Andreoli, V., Gambardella, A., Aguglia, U., Quattrone, A. Neurology (1999) [Pubmed]
  5. Genetic variation analysis in parkinson disease patients with and without hallucinations: case-control study. Goetz, C.G., Burke, P.F., Leurgans, S., Berry-Kravis, E., Blasucci, L.M., Raman, R., Zhou, L. Arch. Neurol. (2001) [Pubmed]
  6. Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients. Thompson, M., Comings, D.E., Feder, L., George, S.R., O'Dowd, B.F. Am. J. Med. Genet. (1998) [Pubmed]
  7. Exclusion of close linkage of bipolar disorder to dopamine D1 and D2 receptor gene markers. Mitchell, P., Selbie, L., Waters, B., Donald, J., Vivero, C., Tully, M., Shine, J. Journal of affective disorders. (1992) [Pubmed]
  8. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Comings, D.E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D., Saucier, G., Ferry, L., Rosenthal, R.J., Lesieur, H.R., Rugle, L.J., MacMurray, P. Mol. Psychiatry (1997) [Pubmed]
  9. D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine. Potkin, S.G., Basile, V.S., Jin, Y., Masellis, M., Badri, F., Keator, D., Wu, J.C., Alva, G., Carreon, D.T., Bunney, W.E., Fallon, J.H., Kennedy, J.L. Mol. Psychiatry (2003) [Pubmed]
  10. A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP. Grandy, D.K., Zhou, Q.Y., Allen, L., Litt, R., Magenis, R.E., Civelli, O., Litt, M. Am. J. Hum. Genet. (1990) [Pubmed]
  11. Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease. Sweet, R.A., Nimgaonkar, V.L., Kamboh, M.I., Lopez, O.L., Zhang, F., DeKosky, S.T. Arch. Neurol. (1998) [Pubmed]
  12. Support for association between ADHD and two candidate genes: NET1 and DRD1. Bobb, A.J., Addington, A.M., Sidransky, E., Gornick, M.C., Lerch, J.P., Greenstein, D.K., Clasen, L.S., Sharp, W.S., Inoff-Germain, G., Wavrant-De Vrièze, F., Arcos-Burgos, M., Straub, R.E., Hardy, J.A., Castellanos, F.X., Rapoport, J.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  13. Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder. Misener, V.L., Luca, P., Azeke, O., Crosbie, J., Waldman, I., Tannock, R., Roberts, W., Malone, M., Schachar, R., Ickowicz, A., Kennedy, J.L., Barr, C.L. Mol. Psychiatry (2004) [Pubmed]
  14. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1. Sherrington, R., Mankoo, B., Attwood, J., Kalsi, G., Curtis, D., Buetow, K., Povey, S., Gurling, H. Genomics (1993) [Pubmed]
  15. Human dopamine D5 receptor pseudogenes. Nguyen, T., Bard, J., Jin, H., Taruscio, D., Ward, D.C., Kennedy, J.L., Weinshank, R., Seeman, P., O'Dowd, B.F. Gene (1991) [Pubmed]
  16. Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse. Liu, H.C., Chen, C.K., Leu, S.J., Wu, H.T., Lin, S.K. Psychiatry Clin. Neurosci. (2006) [Pubmed]
  17. Association of polymorphisms in transduction pathways with suicide attempt in major psychoses. De Luca, V., Ni, X., Wong, A., Kennedy, J.L., de Bartolomeis, A. Psychiatria Danubina. (2006) [Pubmed]
  18. Selective effects of the D1 dopamine receptor agonist, SKF 38393, on behavior maintained by cocaine injection in squirrel monkeys. Katz, J.L., Witkin, J.M. Psychopharmacology (Berl.) (1992) [Pubmed]
  19. Dopamine receptor genes are associated with age at first sexual intercourse. Miller, W.B., Pasta, D.J., MacMurray, J., Chiu, C., Wu, H., Comings, D.E. Journal of biosocial science. (1999) [Pubmed]
  20. Lack of allelic association of dopamine D1 and D2 (TaqIA) receptor gene polymorphisms with reduced dopaminergic sensitivity to alcoholism. Heinz, A., Sander, T., Harms, H., Finckh, U., Kuhn, S., Dufeu, P., Dettling, M., Gräf, K., Rolfs, A., Rommelspacher, H., Schmidt, L.G. Alcohol. Clin. Exp. Res. (1996) [Pubmed]
  21. Association analysis between Tourette's syndrome and dopamine D1 receptor gene in Taiwanese children. Chou, I.C., Tsai, C.H., Lee, C.C., Kuo, H.T., Hsu, Y.A., Li, C.I., Tsai, F.J. Psychiatr. Genet. (2004) [Pubmed]
  22. Effects of dopamine receptor type 1 and Gs protein alpha subunit gene polymorphisms on blood pressure at rest and in response to stress. Lu, Y., Zhu, H., Wang, X., Snieder, H., Huang, Y., Harshfield, G.A., Treiber, F.A., Dong, Y. Am. J. Hypertens. (2006) [Pubmed]
  23. DRD2/DARPP-32 expression correlates with lymph node metastasis and tumor progression in patients with esophageal squamous cell carcinoma. Li, L., Miyamoto, M., Ebihara, Y., Mega, S., Takahashi, R., Hase, R., Kaneko, H., Kadoya, M., Itoh, T., Shichinohe, T., Hirano, S., Kondo, S. World journal of surgery. (2006) [Pubmed]
WikiGenes - Universities