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MeSH Review:

Cell Transformation, Neoplastic

Clemens, F. et al., Cho, Y.Y. et al., Bannasch, P., Kolman, A. et al., Rempel, A. et al., et al.

Dong, Huang, Ma,

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Disease relevance of Cell Transformation, Neoplastic

These observations reveal dynamic changes in CD44 expression during neoplastic cell transformation in cervical intraepithelial neoplasia [1].

High impact information on Cell Transformation, Neoplastic

The r-PTPeta gene encodes a rat receptor-type protein tyrosine phosphatase whose expression is negatively regulated by neoplastic cell transformation [2].
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation [3].
Here, we demonstrate that MLK-like mitogen-activated protein triple kinase (MLTK)-alpha, a member of the MLK family, induced neoplastic cell transformation and tumorigenesis in athymic nude mice [4].
These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development [4].
This review focuses on the current status of the association of Rel/NF-kappa B and I kappa B proteins with neoplastic cell transformation in vitro and in vivo [5].

Chemical compound and disease context of Cell Transformation, Neoplastic

The observed protein binding is discussed with respect to estrogen-induced aneuploidy and neoplastic cell transformation [6].
However, it is conceivable that during neoplastic cell transformation certain metabolites are accumulated in unphysiologically high concentrations (especially intermediates of glucose metabolism) and thereby force the cell to activate alternative metabolic pathways [7].
The neoplastic cell transformation induced by propylene oxide (PO) and epichlorohydrin (ECH) was studied in two in vitro assays, mouse embryo fibroblasts (C3H/10T1/2) and Syrian hamster embryo (SHE) cells [8].
From the available data it is concluded that metabolic activation may play a role in the process of neoplastic cell transformation induced by stilbene estrogens [9].

Biological context of Cell Transformation, Neoplastic

Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation [10].
Taken together, these results suggest that SCD protein and activity levels are associated with the events of neoplastic cell transformation and programmed cell death [11].

Gene context of Cell Transformation, Neoplastic

We have used JB6 cells to study the role of PI-3 K in 12-O-tetradecanoylphorbol-13-acetate (TPA)- or EGF-induced AP-1 activation and neoplastic cell transformation [12].
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development [4].
Over-expression of Ect2 protein is a useful biomarker to detect exposure to nickel compounds and nickel ion-induced morphological and neoplastic cell transformation [13].
Telomerase (a ribonucleoprotein polymerase) activation is frequently observed in various types of neoplastic cell transformation [14].
The data indicate that neoplastic cell transformation is accompanied by progressive alterations in the proportion and subcellular distribution of hexokinase isoenzymes I and II [15].

References

Expression of CD44 and variant isoforms in cervical intraepithelial neoplasia. Dellas, A., Schultheiss, E., Almendral, A.C., Torhost, J., Gudat, F. Gynecol. Oncol. (1996) [Pubmed]
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1). Trapasso, F., Iuliano, R., Boccia, A., Stella, A., Visconti, R., Bruni, P., Baldassarre, G., Santoro, M., Viglietto, G., Fusco, A. Mol. Cell. Biol. (2000) [Pubmed]
Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation. Choi, H.S., Choi, B.Y., Cho, Y.Y., Mizuno, H., Kang, B.S., Bode, A.M., Dong, Z. Cancer Res. (2005) [Pubmed]
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. Cho, Y.Y., Bode, A.M., Mizuno, H., Choi, B.Y., Choi, H.S., Dong, Z. Cancer Res. (2004) [Pubmed]
Rel/NF-kappa B and I kappa B factors in oncogenesis. Luque, I., Gélinas, C. Semin. Cancer Biol. (1997) [Pubmed]
Site-specific covalent binding of stilbene-type and steroidal estrogens to tubulin following metabolic activation in vitro. Epe, B., Hegler, J., Metzler, M. Carcinogenesis (1987) [Pubmed]
Modulation of carbohydrate metabolism during carcinogenesis. Bannasch, P. Cancer Detect. Prev. (1986) [Pubmed]
Comparison of propylene oxide and epichlorohydrin effects in two transformation tests (C3H/10T1/2 and SHE cells). Kolman, A., Dusinská, M. Toxicol. Lett. (1995) [Pubmed]
Metabolic activation of xenobiotic stilbene estrogens. Metzler, M. Fed. Proc. (1987) [Pubmed]
Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation. Epe, B., Harttig, U., Stopper, H., Metzler, M. Environ. Health Perspect. (1990) [Pubmed]
High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Scaglia, N., Caviglia, J.M., Igal, R.A. Biochim. Biophys. Acta (2005) [Pubmed]
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer. Dong, Z., Huang, C., Ma, W.Y. Anticancer Res. (1999) [Pubmed]
Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines. Clemens, F., Verma, R., Ramnath, J., Landolph, J.R. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
Spontaneous neoplastic regression: the significance of apoptosis. Kaiser, H.E., Bodey, B., Siegel, S.E., Gröger, A.M., Bodey, B. In Vivo (2000) [Pubmed]
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Rempel, A., Bannasch, P., Mayer, D. Biochim. Biophys. Acta (1994) [Pubmed]

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