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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Loss, Surgical

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Disease relevance of Blood Loss, Surgical


High impact information on Blood Loss, Surgical


Chemical compound and disease context of Blood Loss, Surgical

  • After early hopeful reports, the ability of desmopressin acetate (DDAVP) to substantially reduce post surgical hemorrhage has been questioned [8].
  • We conclude that dextran and hydroxyethyl starch can be used safely in a dose of 20 ml/kg in component therapy of surgical blood loss, provided that haematocrit is kept at an acceptable level, attention is paid to the postoperative hypoproteinaemia, and the patient has a normal haemostatic function preoperatively [9].
  • Regression analysis was used to determine whether any significant interactions were present between ketorolac and donor age, sex, weight, estimated surgical blood loss, or operative time in terms of its effect on renal function [10].
  • The preoperative administration of danaparoid does not increase surgical blood loss compared with warfarin [11].
  • CONCLUSION: In our study, surgical blood loss was the same for both anesthetic agents overall, but propofol appeared to offer an advantage in terms of subjective improvement in operating conditions, particularly in the ethmoid and sphenoid sinuses [12].

Biological context of Blood Loss, Surgical

  • The effectiveness of general prophylactic use of desmopressin, in order to diminish surgical blood loss and transfusion requirements, has not been proven, except in patients with known bleeding diathesis caused by congenital or acquired haemostatic disorders, e.g. in those taking aspirin [13].

Analytical, diagnostic and therapeutic context of Blood Loss, Surgical


  1. Use of DDAVP for management of surgical hemorrhage from a Doberman pinscher with von Willebrand's disease. Kraus, K.H., Turrentine, M.A., Johnson, G.S. Vet. Clin. North Am. Small Anim. Pract. (1988) [Pubmed]
  2. Anaemia in the critically ill--the optimal haematocrit. Tan, I.K., Lim, J.M. Ann. Acad. Med. Singap. (2001) [Pubmed]
  3. Smoking increases the risk of large scale fluid absorption during transurethral prostatic resection. Hahn, R.G. J. Urol. (2001) [Pubmed]
  4. Where does preoperative erythropoietin therapy count? A mathematical perspective. Brecher, M.E., Goodnough, L.T., Monk, T. Transfusion (1999) [Pubmed]
  5. Effect of haemodilution with diaspirin cross-linked haemoglobin on the oxygen reserve in a rodent model of surgical blood loss. d'Almeida, M.S., White, M., Martin, C.M., Sibbald, W.J., Chin-Yee, I.H. Transfusion medicine (Oxford, England) (2003) [Pubmed]
  6. A kinetic model of the circulatory regulation of tissue plasminogen activator during orthotopic liver transplantation. Crookston, K.P., Marsh, C.L., Chandler, W.L. Blood Coagul. Fibrinolysis (2000) [Pubmed]
  7. Blockade of protein C activation reduces microvascular surgical blood loss. Squires, R.A., Smith, S., Pennington, L.R., Comp, P.C. J. Surg. Res. (1992) [Pubmed]
  8. Effect of desmopressin acetate on hemorrhage without identifiable cause in coronary bypass patients. Cicero, J.L., Massad, M., Matano, J. The American surgeon. (1991) [Pubmed]
  9. A study of haemostasis following the use of high doses of hydroxyethyl starch 120 and dextran in major laparotomies. Halonen, P., Linko, K., Myllylä, G. Acta anaesthesiologica Scandinavica. (1987) [Pubmed]
  10. Effect of ketorolac on renal function after donor nephrectomy. Freedland, S.J., Blanco-Yarosh, M., Sun, J.C., Hale, S.J., Elashoff, D.A., Rajfer, J., Gritsch, H.A. Urology (2002) [Pubmed]
  11. A comparison of danaparoid and warfarin for prophylaxis against deep vein thrombosis after total hip replacement: The Danaparoid Hip Arthroplasty Investigators Group. Comp, P.C., Voegeli, T., McCutchen, J.W., Skoutakis, V.A., Trowbridge, A., Overdyke, W.L. Orthopedics. (1998) [Pubmed]
  12. Propofol versus isoflurane for endoscopic sinus surgery. Pavlin, J.D., Colley, P.S., Weymuller, E.A., Van Norman, G., Gunn, H.C., Koerschgen, M.E. American journal of otolaryngology. (1999) [Pubmed]
  13. Desmopressin--a haemostatic drug: state-of-the-art review. Lethagen, S. European journal of anaesthesiology. Supplement. (1997) [Pubmed]
  14. Blood loss during transurethral resection of the prostate after 3 months of treatment with finasteride. Sandfeldt, L., Bailey, D.M., Hahn, R.G. Urology (2001) [Pubmed]
  15. Managing anemia and blood loss in elective gynecologic surgery patients. Rock, W.A., Meeks, G.R. The Journal of reproductive medicine. (2001) [Pubmed]
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