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Chemical Compound Review

Diaspirin     2-[3-(2-carboxyphenoxy) carbonylpropanoylox...

Synonyms: Salisuccyl, SureCN40799, AG-G-04357, CHEMBL1161014, NSC-518104, ...
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Disease relevance of Diaspirin


High impact information on Diaspirin


Chemical compound and disease context of Diaspirin

  • METHODS: In two separate studies, we investigated small-volume resuscitation (4 mL/kg) using Ringer's lactate, hypertonic saline and dextran, and diaspirin cross-linked hemoglobin in a porcine model of cryogenic brain injury and shock [11].

Biological context of Diaspirin


Anatomical context of Diaspirin


Associations of Diaspirin with other chemical compounds

  • CONCLUSIONS: The endothelin-A receptor antagonist, BQ-123, could attenuate the systemic hemodynamic and regional circulatory effects of diaspirin crosslinked hemoglobin and stroma reduced hemoglobin [13].
  • We investigated cellular injury and death induced by ultrapure human Hb (HbA(0)) and its diaspirin cross-linked derivative DBBF-Hb in normal and glutathione (GSH)-depleted bovine aortic endothelial cells subjected to hydrogen peroxide (H(2)O(2)) [18].
  • RESULTS: Small-volume resuscitation with hypertonic saline and dextran and diaspirin cross-linked hemoglobin significantly improved mean arterial pressure and cerebral perfusion pressure compared with Ringer's lactate [11].
  • In addition, Diaspirin Cross-linked Hemoglobin interfered with measurement of L-lactate using the ACA IV and minor interference was noted with glucose measured using the Beckman CX3 [19].

Gene context of Diaspirin

  • Role of endothelin-converting enzyme in the systemic hemodynamics and regional circulatory effects of proendothelin-1 (1-38) and diaspirin cross-linked hemoglobin in rats [20].
  • Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin [13].
  • This double headed diaspirin was known to crosslink oxy Hb A selectively between Lys 82 beta 1 and Lys 82 beta 2 (Walder, J. A., et al. (1979) Biochemistry 18, 4265) and deoxy Hb A between Lys 99 alpha 1 and Lys 99 alpha 2 (Chatterjee R. Y., et al. (1986) J. Biol. Chem. 261, 9929) [21].
  • Using these criteria, we found significant interference from Diaspirin Cross-linked Hemoglobin with 13 of 29 analytes tested [19].
  • Endothelin plays a role in contractions of isolated pig pulmonary vessels induced by diaspirin cross-linked hemoglobin [22].

Analytical, diagnostic and therapeutic context of Diaspirin


  1. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. Sloan, E.P., Koenigsberg, M., Gens, D., Cipolle, M., Runge, J., Mallory, M.N., Rodman, G. JAMA (1999) [Pubmed]
  2. Diaspirin cross-linked hemoglobin improves neurological outcome following reversible but not irreversible CNS ischemia in rabbits. Bowes, M.P., Burhop, K.E., Zivin, J.A. Stroke (1994) [Pubmed]
  3. Focal cerebral ischemia in rats. Effect of hypervolemic hemodilution with diaspirin cross-linked hemoglobin versus albumin on brain injury and edema. Cole, D.J., Schell, R.M., Drummond, J.C., Reynolds, L. Anesthesiology (1993) [Pubmed]
  4. Site-specific modifications and toxicity of blood substitutes. The case of diaspirin cross-linked hemoglobin. D'Agnillo, F., Alayash, A.I. Adv. Drug Deliv. Rev. (2000) [Pubmed]
  5. Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb) as a vasopressor in critically ill patients. Reah, G., Bodenham, A.R., Mallick, A., Daily, E.K., Przybelski, R.J. Crit. Care Med. (1997) [Pubmed]
  6. Redox cycling of diaspirin cross-linked hemoglobin induces G2/M arrest and apoptosis in cultured endothelial cells. D'Agnillo, F., Alayash, A.I. Blood (2001) [Pubmed]
  7. Combined neuroprotection and reperfusion therapy for stroke. Effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia. Aronowski, J., Strong, R., Grotta, J.C. Stroke (1996) [Pubmed]
  8. Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol). Buehler, P.W., Boykins, R.A., Norris, S., Alayash, A.I. Anal. Chem. (2006) [Pubmed]
  9. Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man. Saxena, R., Wijnhoud, A.D., Man in 't Veld, A.J., van den Meiracker, A.H., Boomsma, F., Przybelski, R.J., Koudstaal, P.J. J. Hypertens. (1998) [Pubmed]
  10. Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit. Meisner, F.G., Kemming, G.I., Habler, O.P., Kleen, M.S., Tillmanns, J.H., Hutter, J.W., Bottino, D.A., Thein, E., Meier, J.M., Wojtczyk, C.J., Pape, A., Messmer, K. Crit. Care Med. (2001) [Pubmed]
  11. Effect of small-volume resuscitation on intracranial pressure and related cerebral variables. Shackford, S.R. The Journal of trauma. (1997) [Pubmed]
  12. Yohimbine modulates diaspirin crosslinked hemoglobin-induced systemic hemodynamics and regional circulatory effects. Sharma, A.C., Gulati, A. Crit. Care Med. (1995) [Pubmed]
  13. Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin. Gulati, A., Sharma, A.C., Singh, G. Crit. Care Med. (1996) [Pubmed]
  14. Diaspirin cross-linked hemoglobin does not increase brain oxygen consumption during hypothermic cardiopulmonary bypass in rabbits. Hindman, B.J., Dexter, F., Cutkomp, J., Smith, T. Anesthesiology (1995) [Pubmed]
  15. Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative Group. Lamy, M.L., Daily, E.K., Brichant, J.F., Larbuisson, R.P., Demeyere, R.H., Vandermeersch, E.A., Lehot, J.J., Parsloe, M.R., Berridge, J.C., Sinclair, C.J., Baron, J.F., Przybelski, R.J. Anesthesiology (2000) [Pubmed]
  16. Dose-dependent effect of diaspirin cross-linked hemoglobin on regional blood circulation of severely hemorrhaged rats. Gulati, A., Sen, A.P. Shock (1998) [Pubmed]
  17. Diaspirin cross-linked hemoglobin improves mucosal perfusion in the ileum of septic rats. Sielenkämper, A.W., Eichelbrönner, O., Martin, C.M., Madorin, S.W., Chin-Yee, I.H., Sibbald, W.J. Crit. Care Med. (2000) [Pubmed]
  18. Interactions of hemoglobin with hydrogen peroxide alters thiol levels and course of endothelial cell death. D'Agnillo, F., Alayash, A.I. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  19. Multiple regression analysis of interference effects from a hemoglobin-based oxygen carrier solution. Kazmierczak, S.C., Catrou, P.G., Best, A.E., Sullivan, S.W., Briley, K.P. Clin. Chem. Lab. Med. (1999) [Pubmed]
  20. Role of endothelin-converting enzyme in the systemic hemodynamics and regional circulatory effects of proendothelin-1 (1-38) and diaspirin cross-linked hemoglobin in rats. Gulati, A., Singh, R., Chung, S.M., Sen, A.P. J. Lab. Clin. Med. (1995) [Pubmed]
  21. The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin. Yang, T., Olsen, K.W. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  22. Endothelin plays a role in contractions of isolated pig pulmonary vessels induced by diaspirin cross-linked hemoglobin. Ledvina, M.A., Hart, J., Bina, S., Jing, M., Muldoon, S. J. Lab. Clin. Med. (1999) [Pubmed]
  23. Filtration of diaspirin crosslinked hemoglobin into lung and soft tissue lymph. Conhaim, R.L., Cooler, S.D., McGrath, A.M., DeAngeles, D.A., Myers, G.A., Harms, B.A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  24. Effects of diaspirin crosslinked haemoglobin during coronary angioplasty in the swine. McKenzie, J.E., Cost, E.A., Scandling, D.M., Ahle, N.W., Savage, R.W. Cardiovasc. Res. (1994) [Pubmed]
  25. Subcutaneous oxygen tension: a useful adjunct in assessment of perfusion status. Powell, C.C., Schultz, S.C., Burris, D.G., Drucker, W.R., Malcolm, D.S. Crit. Care Med. (1995) [Pubmed]
  26. Subarachnoid hemorrhage in rats: effect of singular or sustained hemodilution with alpha-alpha diaspirin crosslinked hemoglobin on cerebral hypoperfusion. Cole, D.J., Reynolds, L.W., Nary, J.C., Drummond, J.C., Patel, P.M., Jacobsen, W.K. Crit. Care Med. (1999) [Pubmed]
  27. Disodium cromoglycate stabilizes mast cell degranulation while reducing the number of hemoglobin-induced microvascular leaks in rat mesentery. Ginsburg, M.I., Baldwin, A.L. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
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