The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

PubChem5746     (2S)-2-chloropropanoic acid

Synonyms: JSPY-st000008, AG-A-07802, AG-E-96522, ACN-S002245, ACN-S002701, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LMFA01090032


High impact information on LMFA01090032


Biological context of LMFA01090032


Anatomical context of LMFA01090032

  • The objectives of the studies described were to assess the ultrastructural neuropathology, blood-brain barrier (BBB) integrity and calcium status of the cerebellum of rats following a single dose of 750 L-2-chloropropionic acid (L-2-CPA) [12].

Associations of LMFA01090032 with other chemical compounds


Analytical, diagnostic and therapeutic context of LMFA01090032


  1. Isolation and characterization of 2,3-dichloro-1-propanol-degrading rhizobia. Effendi, A.J., Greenaway, S.D., Dancer, B.N. Appl. Environ. Microbiol. (2000) [Pubmed]
  2. Haloalkanoate dehalogenase II (DehE) of a Rhizobium sp.--molecular analysis of the gene and formation of carbon monoxide from trihaloacetate by the enzyme. Stringfellow, J.M., Cairns, S.S., Cornish, A., Cooper, R.A. Eur. J. Biochem. (1997) [Pubmed]
  3. Symposium overview: the role of glutathione in neuroprotection and neurotoxicity. Monks, T.J., Ghersi-Egea, J.F., Philbert, M., Cooper, A.J., Lock, E.A. Toxicol. Sci. (1999) [Pubmed]
  4. Putrescine as a marker of the effects of 2-chloropropionic acid in the rat brain. de Vera, N., Camón, L., Martínez, E. Neurosci. Lett. (2004) [Pubmed]
  5. Neuroprotective effects of MK-801 on L-2-chloropropionic acid-induced neurotoxicity. Williams, R.E., Lock, E.A., Bachelard, H.S. J. Neurochem. (2001) [Pubmed]
  6. Evidence for mediation of L-2-chloropropionic acid-induced delayed neuronal cell death by activation of a constitutive nitric oxide synthase. Widdowson, P.S., Farnworth, M., Moore, R.B., Dunn, D., Wyatt, I. Br. J. Pharmacol. (1996) [Pubmed]
  7. Thermoresponsive comb-shaped copolymer-Si(100) hybrids for accelerated temperature-dependent cell detachment. Xu, F.J., Zhong, S.P., Yung, L.Y., Tong, Y.W., Kang, E.T., Neoh, K.G. Biomaterials (2006) [Pubmed]
  8. Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis. Widdowson, P.S., Gyte, A., Upton, R., Foster, J., Coutts, C.T., Wyatt, I. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  9. Cloning, sequencing and expression in Escherichia coli of two Rhizobium sp. genes encoding haloalkanoate dehalogenases of opposite stereospecificity. Cairns, S.S., Cornish, A., Cooper, R.A. Eur. J. Biochem. (1996) [Pubmed]
  10. Changes in cerebellar amino acid neurotransmitter concentrations and receptors following administration of the neurotoxin L-2-chloropropionic acid. Widdowson, P.S., Gyte, A., Simpson, M.G., Wyatt, I., Lock, E.A. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  11. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Widdowson, P.S., Gyte, A.J., Upton, R., Wyatt, I. Brain Res. (1996) [Pubmed]
  12. Ultrastructural pathology and cytochemical investigations of L-2-chloropropionic acid-induced neurointoxication of the rat cerebellum. Jones, H.B., Jenkins, C.R., Bowdler, A.L., Simpson, M.G., Lock, E.A. Acta Neuropathol. (1997) [Pubmed]
  13. L-2-chloropropionic acid-induced cerebellar granule cell necrosis is potentiated by L-type calcium channel antagonists. Widdowson, P.S., Gyte, A., Upton, R., Smith, J.C., Pitts, M., Moores, R., Wyatt, I. Arch. Toxicol. (1997) [Pubmed]
  14. The absence of cerebellar granule cell necrosis in the mouse following L-2-chloropropionic acid administration. Lock, E.A., Gyte, A., Duffell, S., Wyatt, I. Arch. Toxicol. (2000) [Pubmed]
WikiGenes - Universities