Disease relevance of Neurochemistry

• The neurochemistry of therapeutics: levodopa pharmacodynamics in Parkinson's disease [1].
• However, by drawing together the neurochemistry and morphology of epilepsy, we may begin to understand the mechanisms involved in seizure disorders [2].
• Effect of the antitumor drug caracemide on the neurochemistry of murine neuroblastoma cells (clone N1E-115) [3].
• As previously reported, METH-induced hyperthermia and the subsequent loss of striatal DA content were attenuated in animals dosed at 4 degrees C. We also evaluated the effects a hypothermic state induced by pharmacological agents would have on striatal neurochemistry and MPP+ levels following MPTP treatment [4].
• These findings add to the substantial body of evidence suggesting that alcoholic liver disease is associated with abnormal thiamine status and with altered thiamine neurochemistry [5].

Psychiatry related information on Neurochemistry

• CSF neurochemistry of women with anorexia nervosa and normal women [6].
• Although the neurochemistry of Tourette's disorder is not well known, there are some effective therapies for tics, OCD and ADHD [7].
• Striatal neurochemistry and motor activity were assessed in cats treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and killed either when symptomatic for a Parkinson-like motor disorder or six weeks later, when showing significant motor recovery [8].
• None of the NMDA antagonists had any effect on the cerebellar neurochemistry when injected alone or had any effect on animal behavior except for dizocilpine, CPP, CGP40116 and (+/-)HA-966 which resulted in a transient sedation for between three and five hours immediately following their administration [9].
• Serotonin (5-HT) plays a central role in the neurochemistry of the learned helplessness animal model of depression [10].

High impact information on Neurochemistry

• , in this issue of Cell, integrate genetics and functional brain imaging by showing that variation in the human brain-derived neurotrophic factor (BDNF) gene is associated with variation in episodic memory ability and in hippocampal neurochemistry and function [11].
• Gonadal steroid action on the brain: neurochemistry and neuropharmacology [12].
• CONCLUSIONS: Short-term anabolic androgenic steroid use affects brain neurochemistry, increasing CSF 5-HIAA and decreasing MHPG [13].
• Prednisone effects on neurochemistry and behavior. Preliminary findings [14].
• For neurochemistry, basal and K(+)-evoked release of the endogenous amino acids GABA, glutamate (Glu), aspartate (Asp), and tyrosine (Tyr) from micropunches of the CIC were measured in 8 age-paired animals from the 2 age groups using high-performance liquid chromatography [15].

Chemical compound and disease context of Neurochemistry

• We also discussed the unifying theory of the neurochemistry of mood disorders, which integrates the GABA hypothesis into the biogenic amine hypotheses, and indicated future directions for research [16].
• Effects of dietary tyrosine on L-dopa- and amphetamine-induced changes in locomotor activity and neurochemistry in mice [17].
• One week after the last exposure, only males exposed to prenatal MB and adulthood PQ showed significant reductions in locomotor activity (95%) and changes in striatal neurochemistry [18].
• The neurochemistry and physiology of phenytoin causing asterixis has yet to be elucidated [19].

Biological context of Neurochemistry

• Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety [20].
• In this review, the neurochemistry, neuropathology, and neurophysiology associated with vitamin E deficiency are described and correlated [21].
• In the past year, magnetic resonance has assumed an increasingly important role in the study of patients with epilepsy that now extends beyond its demonstration of neuroanatomy and neuropathology into the fields of neurochemistry, neurometabolism and neurophysiology [22].
• These results indicate that gestational treatment with dexamethasone obtunds the normal sex differences in neurochemistry and behavior that are typically seen in adolescence in adulthood, thus producing sex-selective alterations in activity, learning, and memory [23].
• In addition, the similarity between the dorsal horn and nucleus caudalis with respect to the effects of substance P and the opioids suggest a parallel in the neurochemistry of synaptic transmission at the two levels [24].

Anatomical context of Neurochemistry

• Monocular deprivation produces an imbalance in visual drive from the two eyes, which in adult macaque V1 leads to marked changes in the neurochemistry of GABA interneurons [25].
• New research using in vivo microdialysis shows differences in neurochemistry among SSRIs, wherein fluoxetine blocks reuptake of dopamine and norepinephrine, as well as serotonin, in medial prefrontal cortex, and fluvoxamine has a relatively more selective neurochemical profile [26].
• Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain [27].
• Effects of fetal treatment with methylazoxymethanol acetate at various gestational dates on the neurochemistry of the adult neocortex of the rat [28].
• The biochemistry and functional neurochemistry of the synaptosomal plasma membrane phosphoprotein B-50 (GAP-43) are reviewed [29].

Associations of Neurochemistry with chemical compounds

• Altered behavior and neurochemistry during short-term insulin withdrawal in streptozocin-induced diabetic rats [30].
• In 38 healthy subjects, absolute concentrations of N-acetylaspartate (NAA) were measured as a main surrogate parameter for hippocampal neurochemistry on a 3-T scanner [20].
• METHOD: Eighty-three subjects, recorded at coronal autopsy as having had schizophrenia, were referred for neurochemistry studies [31].
• Spider toxins affecting glutamate receptors: polyamines in therapeutic neurochemistry [32].
• Neurochemistry and paroxetine response in major depression [33].

Gene context of Neurochemistry

• These results suggest that overexpression of a mutated PS1 gene induces a subtle alteration in object memory without affecting cholinergic neurochemistry [34].
• The resemblance of this phenotype with the anorexia (anx/anx) mouse mutation prompted us to investigate the hypothalamic neurochemistry of Contactin knock-out (KO) mice [35].
• Neurochemistry within ventrolateral medulla and cardiovascular effects during static exercise following eNOS antagonism [36].
• These findings implicate 5-HT neurochemistry as potentially important therapeutic targets for treating human hyperactivity and possibly childhood ADHD [37].
• In the present study, we investigated the effects of the astrocyte-directed inactivation of Cx43 on mouse behaviour and brain neurochemistry [38].

Analytical, diagnostic and therapeutic context of Neurochemistry

• The combination of raphe stimulation with microdialysis may be a useful way to study the in vivo neurochemistry of DRN/MRN 5-HT pathways [39].
• Animal models indicate that nicotine elicits changes in neural cell replication and differentiation, leading to deficits in synaptic neurochemistry and behavioral performance, many of which first emerge at adolescence [40].
• To determine the neurochemistry of the projection, the distributions of GABA and glutamate immunoreactivity in anterogradely labelled boutons in the entopenducular nucleus were studied by postembedding immunocytochemistry [41].
• Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry [42].
• Assessments of glucose metabolism and other, specific aspects of neurochemistry in AD will provide direct measures of therapeutic drug actions and may permit distinction of symptomatic versus disease-modifying therapies as they are developed and introduced in clinical trials [43].

References