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Chemical Compound Review

Monobutyrin     2,3-dihydroxypropyl butanoate

Synonyms: Mono-n-butyrin, NSC-8451, CHEBI:76503, NSC8451, NSC 8451, ...
 
 
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Disease relevance of butyric acid glyceryl ester

 

High impact information on butyric acid glyceryl ester

 

Biological context of butyric acid glyceryl ester

 

Anatomical context of butyric acid glyceryl ester

  • On a molar basis TB was about 4-fold more potent than either BA or MB for inducing differentiation of HL60 cells [1].
  • Similar fractions from non-adipocyte cell lines failed to synthesize monobutyrin [2].
 

Associations of butyric acid glyceryl ester with other chemical compounds

  • The concept that adipose cells behave as secretory cells is now emerging from in vitro data, since secretion of various proteins (LPL, adipsin, CETP) and important metabolites (fatty acids, monobutyrin, androgens, estrogens, prostaglandins) takes place both constitutively and upon hormonal stimulation [9].
  • The changes of the concentration of tri-, di-, monobutyrin, glycerol, and butyric acid during the reactions catalyzed by soluble, as well as immobilized, lipases were evaluated by gas chromatography [10].

References

  1. Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy. Chen, Z.X., Breitman, T.R. Cancer Res. (1994) [Pubmed]
  2. Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity. Wilkison, W.O., Choy, L., Spiegelman, B.M. J. Biol. Chem. (1991) [Pubmed]
  3. Intravenous feeding of the rat with short chain fatty acid esters. I. Glycerol monobutyrate. Birkhahn, R.H., McMenamy, R.H., Border, J.R. Am. J. Clin. Nutr. (1977) [Pubmed]
  4. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Dobson, D.E., Kambe, A., Block, E., Dion, T., Lu, H., Castellot, J.J., Spiegelman, B.M. Cell (1990) [Pubmed]
  5. Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes. Halvorsen, Y.D., Bursell, S.E., Wilkison, W.O., Clermont, A.C., Brittis, M., McGovern, T.J., Spiegelman, B.M. J. Clin. Invest. (1993) [Pubmed]
  6. Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol. Wilkison, W.O., Spiegelman, B.M. J. Biol. Chem. (1993) [Pubmed]
  7. Butyramide and monobutyrin: growth inhibitory and differentiating agents. Lea, M.A., Xiao, Q., Sadhukhan, A., Sharma, S., Newmark, H.L. Anticancer Res. (1993) [Pubmed]
  8. The adipose tissue as a source of vasoactive factors. Frühbeck, G. Current medicinal chemistry. Cardiovascular and hematological agents. (2004) [Pubmed]
  9. Cellular and molecular aspects of adipose tissue development. Ailhaud, G., Grimaldi, P., Négrel, R. Annu. Rev. Nutr. (1992) [Pubmed]
  10. Influence of the support on the reaction course of tributyrin hydrolysis catalyzed by soluble and immobilized lipases. Otero, C., Pastor, E., Fernández, V.M., Ballesteros, A. Appl. Biochem. Biotechnol. (1990) [Pubmed]
 
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