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Chemical Compound Review

AGN-PC-00HZ60     4-bromocyclohex-2-ene-1,5,6- triol

Synonyms: AG-F-49374, SureCN3943598, AC1L3TWJ, CTK1D6405, AR-1H1113, ...
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Disease relevance of Bromoconduritol


High impact information on Bromoconduritol


Biological context of Bromoconduritol

  • Significant inhibition of fusion was obtained at concentrations as low as 50 micrograms of bromoconduritol/mL, whereas inhibition of cell growth did not occur until concentrations of 250 micrograms/mL were reached [9].

Analytical, diagnostic and therapeutic context of Bromoconduritol

  • Analysis of the iodinated proteins by two-dimensional gel electrophoresis demonstrated that a number of high-molecular-weight proteins (greater than 90,000) detected at the surface of control cells were absent from the surface of cells treated with MDJN or bromoconduritol [9].


  1. Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol. Datema, R., Romero, P.A., Legler, G., Schwarz, R.T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-mice. Pulverer, G., Beuth, J., Ko, H.L., Yassin, A., Ohshima, Y., Roszkowski, K., Uhlenbruck, G. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  3. Bromoconduritol treatment delays intracellular transport of secretory glycoproteins in human hepatoma cell cultures. Yeo, K.T., Yeo, T.K., Olden, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  4. On the role of oligosaccharide trimming in the maturation of Sindbis and influenza virus. Datema, R., Romero, P.A., Rott, R., Schwarz, R.T. Arch. Virol. (1984) [Pubmed]
  5. Effect of bromoconduritol on glucosidase II from rat liver. A new kinetic model for the binding and hydrolysis of the substrate. Alonso, J.M., Santa-Cecilia, A., Calvo, P. Eur. J. Biochem. (1993) [Pubmed]
  6. Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F. Legler, G., Bieberich, E. Arch. Biochem. Biophys. (1988) [Pubmed]
  7. Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3. Tanaka, Y., Kato, J., Kohara, M., Galinski, M.S. Antiviral Res. (2006) [Pubmed]
  8. Effect of the alpha-glucosidase inhibitor, bromoconduritol, on carbohydrate metabolism in the silverleaf whitefly, Bemisia argentifolii. Salvucci, M. Arch. Insect Biochem. Physiol. (2000) [Pubmed]
  9. Inhibition of myoblast fusion by bromoconduritol. Trudel, G.C., Herscovics, A., Holland, P.C. Biochem. Cell Biol. (1988) [Pubmed]
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