Disease relevance of ethylurea

• The treated/control ratio of the incidence of micronucleated polychromatic erythrocytes (MnPCEs) was similar in the two tissues for NDMA at 24 h (sampling at 48 h was precluded by toxicity) and for 7,12-DMBA at 48 h, while it was higher in the bone marrow than in the spleen for NEU at both 24 and 48 h and for 7,12-DMBA at 24 h [1].
• Polycythemia developed in progeny from mothers who were exposed during pregnancy to a combination of methylmercury chloride plus ethylurea and sodium nitrite [2].

High impact information on ethylurea

• To assess their carcinogenic effects, the ethylnitrosourea (ENU) precursors, ethylurea and sodium nitrite, [were administered to pregnant hamsters as a single intragastic] dose on day 15 of gestation, or introduced into the cecum on day 14 [3].
• The pregnant hamsters were exposed to four daily doses of ethylurea (100 mg/kg) and sodium nitrite (50 mg/kg) administered from Day 12 to 15 of pregnancy [4].
• Circular dichroism measurements in the presence of urea, methylurea, and ethylurea indicate a strong hydrophobic stabilization of the neurotoxin [5].
• The number of apoptotic cells was counted following treatment with the direct-acting agents N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) and two agents which require metabolic activation 1,2-dimethylhydrazine (DMH) and N-nitrosodimethylamine (NDMA) [6].
• Concerning micronucleated normochromatic erythrocytes (MnNCEs), their frequency in both tissues was always lower than that of MnPCEs; however, while in bone marrow a marked increase in their incidence was induced by NEU and 7,12-DMBA, any response was absent in spleen, thus suggesting that this organ does not sequester micronucleated erythrocytes [1].

Biological context of ethylurea

• The kinetics of the inhibition of jack bean urease in the presence of ethylurea and N,N-dimethylurea was studied at pH = 7 [7].

Associations of ethylurea with other chemical compounds

• Mutagenic effects of nitrogen dioxide combined with methylurea and ethylurea in Drosophila melanogaster [8].

Gene context of ethylurea

• AB also interacts with freely soluble proteins such as haemoglobin and myoglobin; such binding is disrupted by ethylurea and/or 2% zwitterionic detergent, typical inhibitors of hydrophobic liaisons [9].

References