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Chemical Compound Review

CHEMBL325324     (2S)-1-[(2S)-2-[[(2S)-1-(2...

Synonyms: AG-G-57588, SureCN4190057, G1895_SIGMA, CTK8G0186, FT-0641148, ...
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Disease relevance of Gly-pro-arg-pro


High impact information on Gly-pro-arg-pro


Biological context of Gly-pro-arg-pro


Anatomical context of Gly-pro-arg-pro


Associations of Gly-pro-arg-pro with other chemical compounds


Gene context of Gly-pro-arg-pro

  • Soluble fibrin (produced by adding thrombin to FXIII- and plasminogen-free Fg in the presence of Gly-Pro-Arg-Pro-amide (GPRP-NH2) significantly increased platelet adherence to tumor cells [15].
  • A structural analog of SP1-4 (Gly-Pro-Arg-Pro tetrapeptide) was found to be a strong immunosuppressor at a dose of 5 micrograms/ml, indicating the importance of N-terminal basic residue for the immunoregulatory activity of intact SP [16].
  • This IP1 increment was inhibited by Gly-Pro-Arg-Pro [17].


  1. Sequential determination of ligands binding to discrete components in heterogeneous mixtures by iterative panning and blocking (IPAB). Messmer, B.T., Benham, C.J., Thaler, D.S. J. Mol. Biol. (2000) [Pubmed]
  2. Characterization of a recombinant chimeric plasminogen activator composed of Gly-Pro-Arg-Pro tetrapeptide and truncated urokinase-type plasminogen activator expressed in Escherichia coli. Hua, Z.C., Chen, X.C., Dong, C., Zhu, D.X. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  3. Local thrombin synthesis and fibrin formation in an in vitro thrombosis model result in platelet recruitment and thrombus stabilization on collagen in heparinized blood. Wagner, W.R., Hubbell, J.A. J. Lab. Clin. Med. (1990) [Pubmed]
  4. Effects of fibrinogen-binding tetrapeptides on mechanical properties of fine fibrin clots. Bale, M.D., Müller, M.F., Ferry, J.D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  5. Fibrinopeptide A binds Gly-Pro-Arg-Pro. Root-Bernstein, R.S., Westall, F.C. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  6. Initial interaction between fibrin and tissue plasminogen activator (t-PA). The Gly-Pro-Arg-Pro binding site on fibrin(ogen) is important for t-PA activity. Kaczmarek, E., Lee, M.H., McDonagh, J. J. Biol. Chem. (1993) [Pubmed]
  7. Platelet-induced neutrophil activation: platelet-expressed fibrinogen induces the oxidative burst in neutrophils by an interaction with CD11C/CD18. Ruf, A., Patscheke, H. Br. J. Haematol. (1995) [Pubmed]
  8. Preparation and characterization of fibrinogen-coated, reversibly adhesive, lecithin/cholesterol vesicles. DeAnglis, A.P., Retzinger, G.S. Journal of pharmaceutical sciences. (1995) [Pubmed]
  9. Acceleration of thrombosis and hemolysis by fibrinolysis inhibiting factor and suppression by Ia antigen expressed on T cells in partially hepatectomized Lewis rats. Nakatsuji, T. Int. J. Hematol. (1996) [Pubmed]
  10. Platelet activation by thrombin can be directly measured in whole blood through the use of the peptide GPRP and flow cytometry: methods and clinical applications. Michelson, A.D. Blood Coagul. Fibrinolysis (1994) [Pubmed]
  11. Direct platelet-fibrin interaction that does not require platelet activation. Jen, C.J., Hu, S.J. Am. J. Physiol. (1987) [Pubmed]
  12. Chemically modified thrombin and anhydrothrombin that differentiate macromolecular substrates of thrombin. Hosokawa, K., Ohnishi, T., Kawakami, A., Wakabayashi, S., Koide, T. J. Thromb. Haemost. (2005) [Pubmed]
  13. Ancrod-formed fibrin stimulates prostacyclin production of human umbilical vein endothelial cells via de novo synthesis of cyclooxygenase. Chang, M.C., Wang, C.Y., Huang, T.F. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  14. A novel monoclonal antibody to fibrin monomer and soluble fibrin for the detection of soluble fibrin in plasma. Hamano, A., Tanaka, S., Takeda, Y., Umeda, M., Sakata, Y. Clin. Chim. Acta (2002) [Pubmed]
  15. Soluble fibrin augments platelet/tumor cell adherence in vitro and in vivo, and enhances experimental metastasis. Biggerstaff, J.P., Seth, N., Amirkhosravi, A., Amaya, M., Fogarty, S., Meyer, T.V., Siddiqui, F., Francis, J.L. Clin. Exp. Metastasis (1999) [Pubmed]
  16. Immunoregulatory activity of substance P fragments. Siemion, I.Z., Nawrocka, E., Słoń, J., Pedyczak, A., Kubik, A., Spiegel, K., Zimecki, M., Wieczorek, Z. Mol. Immunol. (1990) [Pubmed]
  17. The morphologic change of endothelial cells by ancrod-generated fibrin is triggered by alpha v beta 3 integrin binding and the subsequent activation of a G-protein coupled phospholipase C. Chang, M.C., Jeng, J.H., Cheong, T.C., Huang, T.F. Biochim. Biophys. Acta (1995) [Pubmed]
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