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Chemical Compound Review

YM-044     sodium(5R,6S)-6-(1- hydroxyethyl)-7-oxo-3...

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Disease relevance of (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid


High impact information on (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid


Analytical, diagnostic and therapeutic context of (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

  • When tested against aerobic bacteria using a high inoculum or using the broth dilution technique, the activity of ALP-201 showed little dependence on inoculum size and the bactericidal activity was similar to the inhibitory activity [3].


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  2. In vitro antibacterial activity and beta-lactamase stability of SY5555, a new oral penem antibiotic. Inoue, E., Mitsuhashi, S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  3. Comparative in vitro activity of the new oral penem ALP-201 against aerobic and anaerobic bacteria. Rylander, M., Nord, C.E., Norrby, S.R. Eur. J. Clin. Microbiol. Infect. Dis. (1989) [Pubmed]
  4. Comparative antibacterial activity of the penem ALP 201. Bergan, T., da Fonseca, J. Chemotherapy. (1991) [Pubmed]
  5. An application of microdialysis to drug tissue distribution study: in vivo evidence for free-ligand hypothesis and tissue binding of beta-lactam antibiotics in interstitial fluids. DeGuchi, Y., Terasaki, T., Yamada, H., Tsuji, A. J. Pharmacobio-dyn. (1992) [Pubmed]
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