The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NUZ2Z     (6R,7S)-7-[[(2E)-2-(2-amino- 1,3-thiazol-4...

Synonyms: FT-0603021, CAS-82547-58-8, Tox21_113302, NCGC00183016-01, DSSTox_CID_28747, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cefteram


High impact information on Cefteram


Chemical compound and disease context of Cefteram


Biological context of Cefteram

  • The kinetics and mechanisms of degradation of the methyl esters and the delta-3 and delta-2 isomers of pivaloyloxymethyl prodrug esters of the new cephalosporin ceftetrame (Ro 19-5247) were investigated in buffer systems and in human plasma in vitro [13].
  • None of the oral cephalosporins were effective (MIC50, greater than 32 micrograms/ml) against enterococci, Pseudomonas aeruginosa and P. maltophilia. beta-lactamase hydrolysis experiments failed to demonstrate significant Ro 19-5247 inactivation by ten commonly encountered chromosomal- or plasmid-mediated enzymes (P99, K1, K14, TEM, CARB, OXA) [4].

Associations of Cefteram with other chemical compounds


  1. In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis. Bowie, W.R., Shaw, C.E., Chan, D.G., Black, W.A. Antimicrob. Agents Chemother. (1987) [Pubmed]
  2. Antimicrobial activity and stability to beta-lactamase of BMY-28271, a new oral cephalosporin ester. Matsui, H., Hiraoka, M., Inoue, M., Mitsuhashi, S. Antimicrob. Agents Chemother. (1990) [Pubmed]
  3. In vitro antibacterial activity and beta-lactamase stability of SY5555, a new oral penem antibiotic. Inoue, E., Mitsuhashi, S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  4. Antimicrobial activity of Ro 19-5247 (T-2525), a new oral cephalosporin, tested against 7,745 recent clinical isolates. Jones, R.N., Fuchs, P.C., Barry, A.L., Ayers, L.W., Gerlach, E.H., Gavan, T.L. Diagn. Microbiol. Infect. Dis. (1987) [Pubmed]
  5. In vitro antibacterial activity of ME1207, a new oral cephalosporin. Miyazaki, S., Miyazaki, Y., Tsuji, A., Nishida, M., Goto, S. Antimicrob. Agents Chemother. (1991) [Pubmed]
  6. Comparative in vitro antibacterial activities of two new oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074). Chau, P.Y., Leung, Y.K., Ng, W.W., Arnold, K. Antimicrob. Agents Chemother. (1987) [Pubmed]
  7. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Wise, R., Andrews, J.M., Piddock, L.J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  8. In vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074). Neu, H.C., Chin, N.X., Labthavikul, P. Antimicrob. Agents Chemother. (1986) [Pubmed]
  9. Comparative antimicrobial activity of ceftibuten against multiply-resistant microorganisms from Belgium. Verbist, L., Jacobs, J., Hens, K. Diagn. Microbiol. Infect. Dis. (1991) [Pubmed]
  10. In vitro activity and beta-lactamase stability of the oral cephalosporin BMY-28100. Hiraoka, M., Masuyoshi, S., Tomatsu, K., Inoue, M., Mitsuhashi, S. Eur. J. Clin. Microbiol. (1987) [Pubmed]
  11. Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin. Onodera, S., Kiyota, H., Endo, K., Suzuki, H., Hosobe, T., Takahashi, T., Egawa, S., Kobayashi, I. J. Infect. Chemother. (2006) [Pubmed]
  12. In vitro activity of RO 19-5247 (T-2525) against intestinal pathogens, glucose non-fermentative gram-negative rods, Legionella and Serratia. Hohl, P., Von Graevenitz, A., Zollinger-Iten, J. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1987) [Pubmed]
  13. Synthesis and mechanisms of decomposition of some cephalosporin prodrugs. Saab, A.N., Hussain, A.A., Patel, I.H., Dittert, L.W. Journal of pharmaceutical sciences. (1990) [Pubmed]
  14. In vitro synergistic effects of double combinations of beta-lactams and azithromycin against clinical isolates of Neisseria gonorrhoeae. Furuya, R., Nakayama, H., Kanayama, A., Saika, T., Iyoda, T., Tatewaki, M., Matsuzaki, K., Kobayashi, I., Tanaka, M. J. Infect. Chemother. (2006) [Pubmed]
WikiGenes - Universities