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MeSH Review


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Disease relevance of Fusobacteria


High impact information on Fusobacteria


Chemical compound and disease context of Fusobacteria

  • beta-Lactamase production (nitrocefin disk method) and agar dilution susceptibility of amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole were determined for 320 Bacteroides species (not Bacteroides fragilis group) and 129 fusobacteria from 28 U.S. centers [10].
  • Although relative drug activities varied by organism, organisms relatively susceptible to one were relatively susceptible to all and organisms relatively resistant to one were relatively resistant to all; an exception was fusobacteria, which were usually susceptible only to azithromycin [11].
  • For the beta-lactamase-positive fusobacteria, greater than or equal to 97% were susceptible to amoxicillin-clavulanate, ampicillin-sulbactam, cefoperazone-sulbactam, trospectomycin, and cefoxitin, 90% were susceptible to cefotetan, and 89% were susceptible to tosufloxacin [12].
  • Coaggregations of fusobacteria with the 63 gram-negative strains were usually inhibited by EDTA, whereas those with the 27 gram-positive strains were usually not inhibited [13].
  • Heat treatment of many of the gram-negative partners not only enhanced their coaggregation with the fusobacteria but also changed lactose-sensitive coaggregations to lactose-insensitive coaggregations [13].

Biological context of Fusobacteria

  • 1. The idea that fermentation acids could prevent the enrichment of fusobacteria in vivo was supported by the observation that dietary lysine supplementation did not enhance the lysine deamination rate of the mixed ruminal bacteria [14].

Gene context of Fusobacteria


  1. Erythromycin for anaerobic pleuropulmonary and soft-tissue infections. Goldstein, E.J., Lewis, R.P., Sutter, V.L., Finegold, S.M. JAMA (1979) [Pubmed]
  2. Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents. Goldstein, E.J., Citron, D.M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  3. Review of the in vitro activity of gemifloxacin against gram-positive and gram-negative anaerobic pathogens. Goldstein, E.J. J. Antimicrob. Chemother. (2000) [Pubmed]
  4. Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora. Edlund, C., Beyer, G., Hiemer-Bau, M., Ziege, S., Lode, H., Nord, C.E. Scand. J. Infect. Dis. (2000) [Pubmed]
  5. Succinate accumulation in pig large intestine during antibiotic-associated diarrhea and the constitution of succinate-producing flora. Tsukahara, T., Ushida, K. J. Gen. Appl. Microbiol. (2002) [Pubmed]
  6. In vitro activities of ABT-773, a new ketolide, against aerobic and anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Goldstein, E.J., Conrads, G., Citron, D.M., Merriam, C.V., Warren, Y., Tyrrell, K. Antimicrob. Agents Chemother. (2001) [Pubmed]
  7. Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens. Goldstein, E.J., Citron, D.M., Merriam, C.V., Warren, Y., Tyrrell, K. Antimicrob. Agents Chemother. (2000) [Pubmed]
  8. In vitro activity of gemifloxacin (SB 265805) against anaerobes. Goldstein, E.J., Citron, D.M., Warren, Y., Tyrrell, K., Merriam, C.V. Antimicrob. Agents Chemother. (1999) [Pubmed]
  9. In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans. Goldstein, E.J., Citron, D.M., Hudspeth, M., Hunt Gerardo, S., Merriam, C.V. Antimicrob. Agents Chemother. (1997) [Pubmed]
  10. Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Appelbaum, P.C., Spangler, S.K., Jacobs, M.R. Antimicrob. Agents Chemother. (1990) [Pubmed]
  11. Erythromycin, clarithromycin, and azithromycin: use of frequency distribution curves, scattergrams, and regression analyses to compare in vitro activities and describe cross-resistance. Fass, R.J. Antimicrob. Agents Chemother. (1993) [Pubmed]
  12. Susceptibilities of 394 Bacteroides fragilis, non-B. fragilis group Bacteroides species, and Fusobacterium species to newer antimicrobial agents. Appelbaum, P.C., Spangler, S.K., Jacobs, M.R. Antimicrob. Agents Chemother. (1991) [Pubmed]
  13. Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria. Kolenbrander, P.E., Andersen, R.N., Moore, L.V. Infect. Immun. (1989) [Pubmed]
  14. Factors affecting lysine degradation by ruminal fusobacteria. Russell, J.B. FEMS Microbiol. Ecol. (2006) [Pubmed]
  15. Characterization of the novel Fusobacterium nucleatum plasmid pKH9 and evidence of an addiction system. Bachrach, G., Haake, S.K., Glick, A., Hazan, R., Naor, R., Andersen, R.N., Kolenbrander, P.E. Appl. Environ. Microbiol. (2004) [Pubmed]
  16. Interleukin-1 and interleukin-1 inhibitor production by human adherent cells stimulated with periodontopathic bacteria. Walsh, L.J., Stritzel, F., Yamazaki, K., Bird, P.S., Gemmell, E., Seymour, G.J. Arch. Oral Biol. (1989) [Pubmed]
  17. Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium spp. Kolenbrander, P.E., Parrish, K.D., Andersen, R.N., Greenberg, E.P. Infect. Immun. (1995) [Pubmed]
  18. Impact on peritonsillar infections and microflora of phenoxymethylpenicillin alone versus phenoxymethylpenicillin in combination with metronidazole. Tunér, K., Nord, C.E. Infection (1986) [Pubmed]
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