Disease relevance of co-Proxamol

• RESULTS: When related to prescription volume overdoses involving co-proxamol in Scotland were 10 times more likely to be fatal (24.6 (19.7, 30.4)) when compared with co-codamol (2.0 (0.88, 4.0)) or co-dydramol (2.4 (0.5, 7.2)) [1].
• AIMS: To assess the relative toxicity of co-proxamol in overdose in comparison to the 2 other paracetamol-opioid combination products, co-codamol and co-dydramol [1].
• A 61-year-old man developed hypersensitivity pneumonitis and skin rash in close association with taking co-proxamol [2].
• Distalgesic abuse and retroperitoneal fibrosis [3].
• Co-proxamol and suicide: a study of national mortality statistics and local non-fatal self poisonings [4].

High impact information on co-Proxamol

• Odds ratios for receiving long-term (>1 month) compared with short-term (1 month) prescriptions for co-proxamol, paracetamol only or a paracetamol combination-type analgesic were calculated for women vs. men, and in those aged over 65 vs. those aged under 65 years [5].
• Eleven patients on long term co-proxamol therapy for pain, in general practice, showed no abnormalities of liver or renal function, as assessed by serum prealbumin concentrations and blood enzyme and electrolyte activities [6].
• Hypersensitivity pneumonitis associated with co-proxamol (paracetamol + dextropropoxyphene) therapy [2].
• Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol [7].
• The mother's pregnancy was complicated by an episode of attempted self harm, with an overdose of co-proxamol at 22 weeks of gestational age, and by the use of cocaine in combination with excess alcohol intake [7].

Chemical compound and disease context of co-Proxamol

• A review of all dextropropoxyphene poisoning episodes in a stable representative population during the past 10 years showed that Distalgesic accounts for most overdoses, and it has become an increasingly popular component of self-poisoning coktails [8].

Biological context of co-Proxamol

• The epidemiology of dextropropoxyphene (Distalgesic) overdose fatalities in Birmingham and the West Midlands [9].
• Pharmacokinetics of dextropropoxyphene and nordextropropoxyphene in elderly hospital patients after single and multiple doses of distalgesic. Preliminary analysis of results [10].

Associations of co-Proxamol with other chemical compounds

• CONCLUSIONS: Co-proxamol was the most commonly prescribed paracetamol-containing analgesic preparation in Ireland. The results may indicate inappropriate use in primary care [5].
• A double-blind comparison of meptazinol versus distalgesic in acute of chronic pain presenting to the general practitioner [11].
• Analgesia following dental surgery: a comparison of brufen and distalgesic [12].

Analytical, diagnostic and therapeutic context of co-Proxamol

• Furthermore, they consumed significantly fewer Di-Antalvic tablets than the control group (13 [7-17] vs 27 [16-32], median [25%-75% interquartile range]) [13].
• Liver function in patients on long-term paracetamol (co-proxamol) analgesia [6].
• A retrospective study of a cohort of 159 co-proxamol overdoses from a combined data set from Edinburgh and Newcastle, Australia was also conducted [14].

References