Disease relevance of Minaline

• Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme [1].
• Pyrrole-2-carboxylate can serve as the sole source of carbon, nitrogen, and energy for a strain tentatively identified to belong to the genus Rhodococcus [2].
• Decrease in pyrrole-2-carboxylic acid excretion during lung cancer disease [3].
• Purification and characterization of a pyrrole-2-carboxylate oxygenase from Arthrobacter strain Py1 [4].
• While nonmalignant lung diseases (bronchopneumonia and chronic bronchitis) do not interfer in the stage I with the drop of pyrrole-2-carboxylic acid excretion, in stage III of lung cancer the decrease is less pronounced and cannot be differentiated from that found in bronchopneumonia or chronic bronchitis [3].

High impact information on Minaline

• Additionally, three configurations of the pyrrole-2-carboxylic acid (PCA) dimer were studied to analyze how the pyrrole pi-electron system influences the carboxylic groups connected by double O-H...O hydrogen bonds [5].
• While a heterologous producer strain harbouring the intact clorobiocin biosynthetic gene cluster accumulated clorobiocin, the cloN1- and cloN7-defective integration mutants accumulated a clorobiocin derivative that lacked the pyrrole-2-carboxyl moiety, while also producing free pyrrole-2-carboxylic acid [6].
• Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910 [7].
• Two-component flavin-dependent pyrrole-2-carboxylate monooxygenase from Rhodococcus sp [2].
• A statistically significant decrease of pyrrole-2-carboxylic acid in urine was observed in lung cancer of stage I (TNM classification) when compared to that of healthy miners (chronically exposed to radiation) from the uranium industry [3].

Associations of Minaline with other chemical compounds

• After reaction with N-chloroglycine, collagen was analyzed for bound available chlorine by iodiometric titration, and hydroxyproline conversion to pyrrole-2-carboxylic acid was measured by they production of a red chromogen after PAB treatment [8].

Analytical, diagnostic and therapeutic context of Minaline

• Rapid method for the analysis of urinary pyrrole-2-carboxylic acid using reversed-phase high-performance liquid chromatography [9].
• The molecular mass of the pyrrole-2-carboxylate oxygenase was about 160 kDa by gel filtration chromatography and native gradient PAGE, only one polypeptide of about 60 kDa was present after SDS-PAGE [4].

References