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Chemical Compound Review

dAMP     [(2R,3S,5R)-5-(6-aminopurin- 9-yl)-3...

Synonyms: Deoxyadenylate, Deoxy-AMP, d-AMP, Oligo(dA), SureCN48174, ...
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Disease relevance of AMP


High impact information on AMP


Biological context of AMP

  • Results for (+)- and (-)-trans-1 and -2 have been compared with results for the modified, single-stranded oligonucleotides ((+)- and (-)-trans-SS-1, and (+)- and (-)-trans-SS-2) and for the cis and trans opened products formed on alkylation at the 6-amino group of 2'-deoxyadenosine 5'-phosphate by (+)-(R,S,S,R)-BPDE ((+)-trans- and (+)-cis-A) [8].
  • In order to characterize the specificity of the aminoacylation reaction, mutant tRNA(Gln) species were synthesized with either a 2'-deoxy AMP or 3'-deoxy AMP as their 3'-terminal nucleotide [9].
  • Poly(dA), unlike poly(A) [Erickson JW, AbouHaidar M, Bancroft JB: Virology 90:60, 1978], was not encapsidated by PMV protein under specific assembly conditions [10].
  • The 2'-deoxyadenosine-5'-phosphate anion, the analogous radical, and the different hydrogen-abstracted radical anions: molecular structures and effects on DNA damage [11].

Anatomical context of AMP


Associations of AMP with other chemical compounds


Gene context of AMP


Analytical, diagnostic and therapeutic context of AMP


  1. In vitro ATP regeneration from polyphosphate and AMP by polyphosphate:AMP phosphotransferase and adenylate kinase from Acinetobacter johnsonii 210A. Resnick, S.M., Zehnder, A.J. Appl. Environ. Microbiol. (2000) [Pubmed]
  2. Conversions of formaldehyde-modified 2'-deoxyadenosine 5'-monophosphate in conditions modeling formalin-fixed tissue dehydration. Rait, V.K., Zhang, Q., Fabris, D., Mason, J.T., O'Leary, T.J. J. Histochem. Cytochem. (2006) [Pubmed]
  3. Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase. Justesen, J., Ferbus, D., Thang, M.N. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  4. Cloning, sequencing, and expression of the genes encoding subunits of Paracoccus denitrificans electron transfer flavoprotein. Bedzyk, L.A., Escudero, K.W., Gill, R.E., Griffin, K.J., Frerman, F.E. J. Biol. Chem. (1993) [Pubmed]
  5. DNA damage induced by the environmental carcinogen butadiene: identification of a diepoxybutane-adenine adduct and its detection by 32P-postlabelling. Leuratti, C., Jones, N.J., Marafante, E., Kostiainen, R., Peltonen, K., Waters, R. Carcinogenesis (1994) [Pubmed]
  6. Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase. Tan, C.K., Zhang, J., Li, Z.Y., Tarpley, W.G., Downey, K.M., So, A.G. Biochemistry (1991) [Pubmed]
  7. Penetration of mouse fibroblasts by 2'-deoxyadenosine 5'-phosphate and incorporation of the nucleotide into DNA. Plunkett, W., Cohen, S.S. J. Cell. Physiol. (1977) [Pubmed]
  8. Multiple fluorescence lifetimes for oligonucleotides containing single, site-specific modifications at guanine and adenine corresponding to trans addition of exocyclic amino groups to (+)-(7R,8S,9S,10R)- and (+)-(7S,8R,9R,10S) -7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. LeBreton, P.R., Huang, C.R., Fernando, H., Zajc, B., Lakshman, M.K., Sayer, J.M., Jerina, D.M. Chem. Res. Toxicol. (1995) [Pubmed]
  9. Mutant enzymes and tRNAs as probes of the glutaminyl-tRNA synthetase: tRNA(Gln) interaction. Englisch-Peters, S., Conley, J., Plumbridge, J., Leptak, C., Söll, D., Rogers, M.J. Biochimie (1991) [Pubmed]
  10. The assembly of papaya mosaic virus coat protein with DNA. Erickson, J.W., Bancroft, J.B. Prog. Clin. Biol. Res. (1980) [Pubmed]
  11. The 2'-deoxyadenosine-5'-phosphate anion, the analogous radical, and the different hydrogen-abstracted radical anions: molecular structures and effects on DNA damage. Hou, R., Gu, J., Xie, Y., Yi, X., Schaefer Iii, H.F. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  12. Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro. Krzeminski, J., Desai, D., Lin, J.M., Serebryany, V., El-Bayoumy, K., Amin, S. Chem. Res. Toxicol. (2000) [Pubmed]
  13. Characterization of DNA strand breakage in vitro by the antitumor protein neocarzinostatin. Poon, R., Beerman, T.A., Goldberg, I.H. Biochemistry (1977) [Pubmed]
  14. Analysis of melphalan adducts of 2'-deoxynucleotides in calf thymus DNA hydrolysates by capillary high-performance liquid chromatography-electrospray tandem mass spectrometry. Hoes, I., Lemière, F., Van Dongen, W., Vanhoutte, K., Esmans, E.L., Van Bockstaele, D., Berneman, Z., Deforce, D., Van den Eeckhout, E.G. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
  15. Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion. Holen, E., Bjørge, O.A., Jonsson, R. Nutrition (Burbank, Los Angeles County, Calif.) (2005) [Pubmed]
  16. Fast repair of dAMP radical anions by phenylpropanoid glycosides and their analogs. Shi, Y., Wang, W., Fan, B., Jia, Z., Yao, S., Zheng, R. Biochim. Biophys. Acta (2000) [Pubmed]
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