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Chemical Compound Review

DM-COOK     potassium4- dimethylaminodiazenylbenzoate

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Disease relevance of CB 10277

  • DM-COOK thus appears to exert selective antimetastatic effects, unrelated to cytotoxicity for tumor cells, against B16 melanoma in addition to those reported for Lewis lung carcinoma and M5 ovarian reticular cell sarcoma; its therapeutic usefulness is evidenced in adjuvant surgical experiments [1].
  • In hosts pretreated with DM-COOK, no reduction in the formation either of spontaneous or of artificial metastases is observed [2].
  • DM-COOK, unlike DTIC, is devoid of hematological toxicity for the host [1].
  • The antitumor and antimetastatic effects of p-(3-methyl-1-triazeno)benzoic acid potassium salt (MM-COOK) as compared with those of the parent 3,3-dimethyl derivative (DM-COOK) were examined using Lewis lung carcinoma, MCa mammary carcinoma of the CBA mouse and TLX5 lymphoma [3].
  • DM-COOK and DTIC thus possess a mild or insignificant cytotoxic action together with antimetastatic properties also on mouse transplantable leukemias [4].

High impact information on CB 10277

  • At the same time, DM-COOK does not affect artificial metastases or spontaneous metastases in mice undergoing surgery and treated with DM-COOK postoperatively [1].
  • While some of the aryl-triazenes tested (DM-COOK DM-NO2) showed a pattern of immunodepression similar to that of DTIC, others were less (MIC, MM-COOK, MM-Cl) or far less (DM-Cl, MM-NO2) active than DTIC in impairing host immunocompetence, although all retained or even augmented their ability to induce chemical xenogenization [5].
  • However, DM-COOK, unlike indomethacin, causes an inhibition of leukocyte migration into the peritoneal cavity induced by casein treatment, thus indicating a different mechanism of action [6].
  • The effects of a selective antimetastatic agent: the aryldimethyltriazene derivative 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK) have been examined on two in vitro tumor cell lines derived from lung metastases of Lewis lung carcinoma [7].
  • The antitumor activity caused by the synthesized compounds in mice bearing either Lewis lung carcinoma or TLX5 lymphoma was evaluated and discussed in comparison with the parent compound (p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK, CAS 70055-49-1) [8].

Chemical compound and disease context of CB 10277


Analytical, diagnostic and therapeutic context of CB 10277

  • Like other phenyldimethyltriazenes DM-COOK, is a good candidate for clinical trials because its water solubility eliminates formulation problems [10].
  • The in vivo bioassays of brains, and the histologic examinations of the livers of leukemic mice show that DM-COOK and DTIC prevent leukemic infiltration in these organs at dosages devoid of cytotoxic effects for peritoneal tumor cells [4].


  1. Antimetastatic action and hematological toxicity of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt and 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide used as prophylactic adjuvants to surgical tumor removal in mice bearing B16 melanoma. Sava, G., Giraldi, T., Lassiani, L., Nisi, C. Cancer Res. (1984) [Pubmed]
  2. Selectivity of the antimetastatic and cytotoxic effects of 1-p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (+/-)-1,2-di(3,5-dioxopiperazin-1-yl)propane, and cyclophosphamide in mice bearing Lewis lung carcinoma. Giraldi, T., Sava, G., Cuman, R., Nisi, C., Lassiani, L. Cancer Res. (1981) [Pubmed]
  3. Antineoplastic action of p-(3-methyl-1-triazeno)benzoic acid potassium salt, a monomethyl derivative of the antimetastatic compound DM-COOK. Sava, G., Zorzet, S., Perissin, L., Pacor, S., Lassiani, L., Nisi, C., Varnavas, A. Cancer Chemother. Pharmacol. (1991) [Pubmed]
  4. Infiltration of liver and brain by tumor cells in leukemic mice: prevention by dimethyltriazenes and cyclophosphamide. Sava, G., Giraldi, T., Perissin, L., Zorzet, S., Mallardi, F., Grill, V. Tumori. (1984) [Pubmed]
  5. Chemical xenogenization of murine lymphoma cells with triazene derivatives: immunotoxicological studies. Nardelli, B., Puccetti, P., Romani, L., Sava, G., Bonmassar, E., Fioretti, M.C. Cancer Immunol. Immunother. (1984) [Pubmed]
  6. Antiinflammatory action of hydrosoluble dimethyltriazenes on the carrageenin-induced edema in guinea pigs. Sava, G., Perissin, L., Lassiani, L., Zabucchi, G. Chem. Biol. Interact. (1985) [Pubmed]
  7. Effects of dimethyltriazenes on in vitro Lewis lung carcinoma tumor lines with different metastatic capacity. Zupi, G., Corsi, A., Sacchi, A., Lassiani, L., Giraldi, T. Invasion Metastasis (1984) [Pubmed]
  8. Synthesis and antitumor activity of hydrosoluble analogs of p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. Varnavas, A., Nisi, C., Lassiani, L., Sava, G., Perissin, L., Boccù, E. Arzneimittel-Forschung. (1991) [Pubmed]
  9. Effects of DTIC, DM-COOK and ICRF-159 on the number of circulating Lewis lung carcinoma cells detected by flow cytometry. Giraldi, T., Sava, G., Cherubino, R., Bottiroli, G., Mazzini, G. Clin. Exp. Metastasis (1984) [Pubmed]
  10. Comparison of the antitumor activity of DTIC and 1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt on murine transplantable tumors and their hematological toxicity. Colombo, T., D'Incalci, M. Cancer Chemother. Pharmacol. (1984) [Pubmed]
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