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MeSH Review

Leukemic Infiltration

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Disease relevance of Leukemic Infiltration


High impact information on Leukemic Infiltration

  • In nonobese diabetic/severe combined immunodeficient (NOD/SCID)/gammacnull (NOG) mice, ritonavir very efficiently prevented tumor growth and leukemic infiltration in various organs of NOG mice at the same dose used for treatment of patients with AIDS [4].
  • Bay 11-7082, a specific and effective NF-kappaB inhibitor, prevented tumor growth at the sites of the primary region and leukemic infiltration in various organs of NOG mice [5].
  • Our hypothesis is that eradication of hepatic leukemic infiltration by ALL remission therapy resulted in an improvement in microsomal metabolism of antipyrine and lorazepam [6].
  • One reason for the poor outcome in ANKL is leukemic infiltration into multiple organs [7].
  • The morphologic picture and the long time that elapsed from the diagnosis raised the suspicion of a cerebral neoplasm; the immediate and dramatic effect of steroid treatment, on the contrary, indicated the presence of a leukemic infiltration and in the meantime, a bone marrow relapse occurred [8].

Chemical compound and disease context of Leukemic Infiltration


Anatomical context of Leukemic Infiltration


Gene context of Leukemic Infiltration

  • However, a large dose of TNF alpha (100 ng) had no suppressive effect on tumor growth and leukemic infiltration in mouse organs [13].
  • Leukemic infiltration of the eye may occur with increasing frequency in CML as the survival following bastic transformation improves [14].
  • CONCLUSIONS: These results indicate that leukemic cells were unable to produce CA 125 and suggest that its elevation in the serum is likely due to a serosal inflammatory reaction caused by the leukemic infiltration [15].
  • High levels of leukemic infiltration were observed in peripheral organs in mice with Matrigel by flow cytometry and PCR for human beta-actin mRNA expression, while mice without Matrigel showed low or undetectable infiltration in these organs [13].


  1. Cutaneous findings in hairy cell leukemia. Finan, M.C., Su, W.P., Li, C.Y. J. Am. Acad. Dermatol. (1984) [Pubmed]
  2. Changes in drug delivery (by blood-brain barrier dysfunction) on arachnoid leukemia: implication for CNS leukemic dissemination. Suzuki, M., Abe, I., Sato, H. Clin. Exp. Metastasis (1983) [Pubmed]
  3. Extensive pulmonary infiltration by leukemic blasts successfully treated with hydroxyurea--a case report. Huang, P.H., You, J.Y., Hsu, H.C. Haematologia (Budap) (2002) [Pubmed]
  4. Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir. Dewan, M.Z., Uchihara, J.N., Terashima, K., Honda, M., Sata, T., Ito, M., Fujii, N., Uozumi, K., Tsukasaki, K., Tomonaga, M., Kubuki, Y., Okayama, A., Toi, M., Mori, N., Yamamoto, N. Blood (2006) [Pubmed]
  5. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. Dewan, M.Z., Terashima, K., Taruishi, M., Hasegawa, H., Ito, M., Tanaka, Y., Mori, N., Sata, T., Koyanagi, Y., Maeda, M., Kubuki, Y., Okayama, A., Fujii, M., Yamamoto, N. J. Virol. (2003) [Pubmed]
  6. Hepatic drug clearance in children with leukemia: changes in clearance of model substrates during remission-induction therapy. Relling, M.V., Crom, W.R., Pieper, J.A., Cupit, G.C., Rivera, G.K., Evans, W.E. Clin. Pharmacol. Ther. (1987) [Pubmed]
  7. Significance of chemokine receptor expression in aggressive NK cell leukemia. Makishima, H., Ito, T., Asano, N., Nakazawa, H., Shimodaira, S., Kamijo, Y., Nakazawa, Y., Suzuki, T., Kobayashi, H., Kiyosawa, K., Ishida, F. Leukemia (2005) [Pubmed]
  8. Parenchymal brain leukemia. Case report: problems related to the diagnosis and treatment. Corbetta, A., Jankovic, M., Conter, V., Fuga, T., Crivellaro, M., Masera, G. Haematologica (1991) [Pubmed]
  9. Effects of antimetastatic, antiinvasive and cytotoxic agents on the growth and spread of transplantable leukemias in mice. Sava, G., Giraldi, T., Perissin, L., Zorzet, S., Decorti, G. Clin. Exp. Metastasis (1987) [Pubmed]
  10. Infiltration of liver and brain by tumor cells in leukemic mice: prevention by dimethyltriazenes and cyclophosphamide. Sava, G., Giraldi, T., Perissin, L., Zorzet, S., Mallardi, F., Grill, V. Tumori. (1984) [Pubmed]
  11. EEG-changes during intensified induction-therapy of acute lymphoblastic leukemia. Korinthenberg, R., Palm, D., Rübig, A., Schellong, G. Neuropädiatrie. (1979) [Pubmed]
  12. Spontaneous remission of acute myeloid leukemia after infection and blood transfusion associated with hypergammaglobulinaemia. Mitterbauer, M., Fritzer-Szekeres, M., Mitterbauer, G., Simonitsch, I., Knöbl, P., Rintelen, C., Schwarzinger, I., Haas, O.A., Silberbauer, K., Frey, K., Bibus, B., Pabinger, I., Radaszkiewicz, T., Lechner, K., Jaeger, U. Ann. Hematol. (1996) [Pubmed]
  13. Suppression of growth and dissemination in human pre-B leukemia cells by tumor necrosis factor-alpha in scid mice. Yoshida, N., Ishii, E., Mohri, S., Nagumo, F., Yoshidomi, S., Miyazaki, S. Leuk. Lymphoma (1999) [Pubmed]
  14. Ocular complications following blast transformation in chronic myelogenous leukemia. Hendrick, A.M., Rogers, J.S., Guliner, R.J. Am. J. Hematol. (1979) [Pubmed]
  15. Increased CA 125 serum levels in patients with advanced acute leukemia with serosal involvement. Camera, A., Villa, M.R., Rocco, S., De Novellis, T., Costantini, S., Pezzullo, L., Lucania, A., Mariano, A., Macchia, V., Rotoli, B. Cancer (2000) [Pubmed]
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