Disease relevance of p-Phenylbenzyl chloride

• Mutagenicity of 4-chloromethylbiphenyl in repair-deficient strains of Salmonella typhimurium [1].
• UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100 [2].
• The induction of mutants in L5178Y mouse lymphoma cells by 4-chloromethylbiphenyl [3].

High impact information on p-Phenylbenzyl chloride

• Benzyl chloride (BC) and 4-chloromethylbiphenyl (4CMB) induce a class of alkaline-stable DNA damage in human cells which, like UV-induced pyrimidine dimers, undergoes repair at a slow rate by an excision-repair pathway which can be inhibited by cytosine arabinoside (araC) [4].
• Benzyl chloride and 4-chloromethylbiphenyl induced DNA damage and its repair in excision-deficient (XP group A) or -proficient human cells [4].
• Mutagenicity of 4-chloromethylbiphenyl (4CMB) to E. coli WP2 uvrA pKM101 [5].
• The genetic toxicology in fungi of 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB) and benzyl chloride (BC). Survey of the results of the U.K.E.M.S. collaborative genotoxicity trial 1981 [6].
• An assessment of the clastogenic potential of 4-chloromethylbiphenyl in human lymphocytes in vitro [7].

Biological context of p-Phenylbenzyl chloride

• An investigation of DNA-repair phenomena induced by 4-chloromethylbiphenyl (4CMB) [8].
• Investigation of the cytogenetic effects of 4-chloromethylbiphenyl (4CMB) on cultured rat-liver cells [9].
• To study possible clastogenic effects of 4-chloromethylbiphenyl (4CMB), a mouse micronucleus test was performed (as part of the UKEMS genetic toxicology trial) [10].
• Sister-chromatid exchanges in human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride [11].
• Metaphase analysis of human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride [12].

Anatomical context of p-Phenylbenzyl chloride

• Thus, in this test, 4CMB did not induce chromosomal damage resulting in micronucleus formation, in bone-marrow erythrocytes [10].
• Mutagenicity of 4-chloromethylbiphenyl in the Salmonella/microsome assay [13].

Associations of p-Phenylbenzyl chloride with other chemical compounds

• DNA damage and its repair in cultured human alveolar tumor cells treated with benzyl chloride, 4-chloromethylbiphenyl or 4-hydroxymethylbiphenyl [14].
• Although the range of dosages employed included highly toxic or lethal doses, the frequency of micronucleated polychromatic erythrocytes in the bone marrow was not significantly greater in 4CMB-treated groups, than in control-group animals treated with the Tween 80 vehicle alone [10].

Analytical, diagnostic and therapeutic context of p-Phenylbenzyl chloride

• Mice were given 4CMB by intraperitoneal injection, once daily for 5 consecutive days [10].
• Bacterial mutagenicity tests on 4-chloromethylbiphenyl and 2 structural analogues [15].

References