Disease relevance of chloromethylbenzene

• On the basis of a subchronic study at a range of doses, the doses of benzyl chloride in the chronic study were 100 and 50 mg/kg body weight for mice and 30 and 15 mg/kg body weight for rats [1].
• 4-Chloromethylbiphenyl, 4-hydroxymethylbiphenyl and benzyl chloride: a comparison of mutagenic potential using the Salmonella reverse mutation assay [2].
• However, as toxicity increased BC showed much more potent convertogenic activity, whereas with 4CMB a reduction in induced gene conversion was observed [3].
• 4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethyl-biphenyl (4HMB) were tested for biological activity in the following assays: (i) the Salmonella/microsome assay; (ii) a bacterial 'fluctuation' assays; (iii) a DNA repair assay in Hela cells, and (iv) a mouse lymphoma mutation assay [4].
• Benzotrichloride (BTC), benzal chloride (BDC), benzyl chloride (BC) and benzoyl chloride (BOC) were surveyed for their mutagenicity in microbial systems such as rec-assay using Bacillus subtilis and reversion assays using E. coli WP2 and Ames Salmonella TA strains with or without metabolic activation in vitro [5].

High impact information on chloromethylbenzene

• Carboxyl-functional ionic liquids as scavengers: case studies on benzyl chloride, amines, and methanesulfonyl chloride [6].
• Alkylation of the 2-thio analogs 15-17 and 24-26 with benzyl chloride furnished the 2-alkylthio acyclic nucleosides 12d-14d and 21d-23d [7].
• Production and photoexcited dynamics of reaction intermediates with photolyses of benzyl chloride (BzCl) and methyl-substituted benzyl chlorides (MeBzCls) were studied by using stepwise two-color laser excitation transient absorption (TC-TA) and two-color laser excitation time-resolved thermal lensing (TC-TRTL) measurements [8].
• In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated [9].
• 4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethylbiphenyl (4HMB): reverse mutation tests with Salmonella typhimurium [10].

Chemical compound and disease context of chloromethylbenzene

• The carcinogenicity of benzyl chloride (BYC), benzal chloride (BAC), benzotrichloride (BTC) and benzoyl chloride (BOC), which were suspected as causative agents of lung cancer and maxillary malignant lymphoma of workers employed in factories producing BOC, was examined by skin applications in female ICR mice [11].

Biological context of chloromethylbenzene

• The results reported in this paper indicate that both 4CMB and BC are genetically active in yeast, producing dose-related increases in mitotic gene conversion at both the loci tested; 4HMB showed no such activity [3].
• BC was weakly mutagenic without metabolic activation [5].
• The genetic toxicology of 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB) and benzyl chloride (BC) as assessed by the UKEMS genotoxicity trial (1981) [12].
• Occupational exposure to benzyl chloride and benzyl chloride due to contaminated butyl benzyl phthalate [13].
• Isotopic affiliation between precursors and products is investigated in several types of reactions: oxidation of benzyl chloride and benzyl alcohol and hydrolysis of benzylidene chloride and cinnamaldehyde [14].

Anatomical context of chloromethylbenzene

• The mutagenic activity of 4-chloromethylbiphenyl (4CMB) and benzyl chloride (BC) in the bacterial/microsome assay [15].
• Genetic activities of 4-chloromethylbiphenyl, the 4-hydroxy derivative and benzyl chloride in the soma and germ line of Drosophila melanogaster [16].
• The ratio of found and expected degree of alkylation of DNA was about 3 times higher for testis and brain than for the other organs 1 h after administration of benzyl chloride [17].
• Effect of benzyl chloride on rat hepatocytes [18].

Analytical, diagnostic and therapeutic context of chloromethylbenzene

• Chronic bioassay of benzyl chloride in F344 rats and (C57BL/6J x BALB/c)F1 mice [1].

References