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Chemical Compound Review

Antheridiol     4-[(1S,2S,3S)-1,2-dihydroxy- 3-[(3S,8S,9S...

Synonyms: AC1L4MQT, 22263-79-2
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High impact information on Antheridiol

  • Induction of specific proteins in hyphae of Achlya ambisexualis by the steroid hormone antheridiol [1].
  • Using these approaches the addition of the hormone antheridiol to vegetatively growing cells of Achlya E87 was found to result in changes in the synthesis and/or accumulation of at least 16 specific proteins, which could be localized to the cytoplasmic, nuclear or cell wall/cell membrane fractions [2].
  • Radioligand-binding studies have revealed the presence of a specific binding protein in the cytosol of male cells that may represent the endogenous receptor for antheridiol [3].
  • We recently identified a steroid receptor in the aquatic fungus Achlya ambisexualis where sexual morphogenesis of the male is directed by the steroid antheridiol [4].
  • It was of interest to determine if the antheridiol-induced "70-kDa" proteins were hsp70-family heat shock proteins and if hormone treatment-induced changes in the level of hsp70 transcripts [5].

Biological context of Antheridiol


Anatomical context of Antheridiol


Gene context of Antheridiol


Analytical, diagnostic and therapeutic context of Antheridiol

  • To investigate the effects of antheridiol on the synthesis and/or accumulation of specific cellular proteins we have analysed [35S]methionine-labeled proteins from control and hormone-treated cells using both one-dimensional (1D) and two-dimensional (2D) PAGE [2].


  1. Induction of specific proteins in hyphae of Achlya ambisexualis by the steroid hormone antheridiol. Groner, B., Hynes, N., Sippel, A., Schutz, G. Nature (1976) [Pubmed]
  2. Cellular localization of steroid hormone-regulated proteins during sexual development in Achlya. Brunt, S.A., Silver, J.C. Exp. Cell Res. (1986) [Pubmed]
  3. Detection of a pheromone-binding protein in the aquatic fungus Achlya ambisexualis. Riehl, R.M., Toft, D.O., Meyer, M.D., Carlson, G.L., McMorris, T.C. Exp. Cell Res. (1984) [Pubmed]
  4. Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species. Riehl, R.M., Sullivan, W.P., Vroman, B.T., Bauer, V.J., Pearson, G.R., Toft, D.O. Biochemistry (1985) [Pubmed]
  5. Regulation of two different hsp70 transcript populations in steroid hormone-induced fungal development. Silver, J.C., Brunt, S.A., Kyriakopoulou, G., Borkar, M., Nazarian-Armavil, V. Dev. Genet. (1993) [Pubmed]
  6. Effect of culture medium composition on pheromone receptor levels in Achlya ambisexualis. Riehl, R.M., Toft, D.O. J. Steroid Biochem. (1985) [Pubmed]
  7. Hormonal stimulation of ribosomal RNA synthesis in Achlya ambisexualis. Horgen, P.A., Smith, R., Silver, J.C., Craig, G. Can. J. Biochem. (1975) [Pubmed]
  8. Regulation of hsp90 and hsp70 genes during antheridiol-induced hyphal branching in the oomycete Achlya ambisexualis. Brunt, S.A., Borkar, M., Silver, J.C. Fungal Genet. Biol. (1998) [Pubmed]
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