Disease relevance of Achlya

• This unusual dinucleotide may be an important regulator of eucaryotic ribonucleoside diphosphate reductase activity; for 50 micrometer HS3, isolated from either mammalian or fungal cells, significantly inhibited CDP reduction in Achlya or hamster cell preparations, but only marginally affected the activity of the enzyme from E. coli [1].
• Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis [2].

High impact information on Achlya

• When hyphae of the water mold Achlya were subjected to osmotic stress, imposed with polyethylene glycol (PEG)-300 or sucrose, turgor pressure fell in proportion to the increase in external osmotic pressure [3].
• The steroid hormone antheridiol regulates sexual development in the fungus Achlya ambisexualis [4].
• An NAD(+)-specific glutamate dehydrogenase (NAD-GDH) that is inducible by L-glutamine was isolated from Achlya klebsiana and purified to electrophoretic homogeneity [5].
• Incubation of Achlya ambisexualis at elevated temperature (heat shock) or in the presence of sodium arsenite resulted in an inhibition of steroid hormone-induced responsiveness [6].
• This was accompanied by dephosphorylation of a prominent basic 30 kD protein associated with the small subunit of Achlya ribosomes and which may be analogous to ribosomal protein S6 of vertebrates [7].

Biological context of Achlya

• Alterations in RNA and protein synthesis associated with steroid hormone-induced sexual morphogenesis in the water mold Achlya [8].

Anatomical context of Achlya

• Using these approaches the addition of the hormone antheridiol to vegetatively growing cells of Achlya E87 was found to result in changes in the synthesis and/or accumulation of at least 16 specific proteins, which could be localized to the cytoplasmic, nuclear or cell wall/cell membrane fractions [9].

Associations of Achlya with chemical compounds

• Using PLATS, sequence has been obtained from a 1.1-kb segment in Achlya ambisexualis, which cross-hybridizes to the DNA-binding region of the chicken and Xenopus estrogen receptors [10].
• Synthesis of dehydro-oogoniol, a female-activating hormone of Achlya: the progesterone route [11].
• We present immunocytochemical data that indicate the presence of, and a close association between beta4 integrin-like proteins and proteins containing phosphorylated tyrosine residues in the oomycete Achlya bisexualis [12].
• Differential uptake and metabolism of sitosterol and cholesterol by Achlya, Pythium, and Phytophthora species [13].
• Species of Pythium and Phytophthora took up cholesterol and sitosterol efficiently, whereas Achlya species took up booth sterols inefficiently [13].

Gene context of Achlya

• In the oomycete Achlya ambisexualis two populations of hsp90 transcripts that differ slightly in size (2.8 and 2.9 kb) are present in heat-shocked mycelia [14].
• Two different Achlya hsp70 genomic sequences were cloned and used to investigate these questions [15].
• In Achlya ambisexualis, hsp85 is one of the characteristic mycelial heat shock proteins induced in response to a rapid elevation in temperature (Silver et al. 1983) [16].
• The putative peptide shows 47% homology to the NAD-specific glutamate dehydrogenase of Achlya klebsiana [17].

Analytical, diagnostic and therapeutic context of Achlya

• Molecular cloning and characterization of two different cDNAs encoding the molecular chaperone Hsp90 in the oomycete Achlya ambisexualis [14].

References