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MeSH Review


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Disease relevance of Achlya

  • This unusual dinucleotide may be an important regulator of eucaryotic ribonucleoside diphosphate reductase activity; for 50 micrometer HS3, isolated from either mammalian or fungal cells, significantly inhibited CDP reduction in Achlya or hamster cell preparations, but only marginally affected the activity of the enzyme from E. coli [1].
  • Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis [2].

High impact information on Achlya


Biological context of Achlya


Anatomical context of Achlya

  • Using these approaches the addition of the hormone antheridiol to vegetatively growing cells of Achlya E87 was found to result in changes in the synthesis and/or accumulation of at least 16 specific proteins, which could be localized to the cytoplasmic, nuclear or cell wall/cell membrane fractions [9].

Associations of Achlya with chemical compounds


Gene context of Achlya

  • In the oomycete Achlya ambisexualis two populations of hsp90 transcripts that differ slightly in size (2.8 and 2.9 kb) are present in heat-shocked mycelia [14].
  • Two different Achlya hsp70 genomic sequences were cloned and used to investigate these questions [15].
  • In Achlya ambisexualis, hsp85 is one of the characteristic mycelial heat shock proteins induced in response to a rapid elevation in temperature (Silver et al. 1983) [16].
  • The putative peptide shows 47% homology to the NAD-specific glutamate dehydrogenase of Achlya klebsiana [17].

Analytical, diagnostic and therapeutic context of Achlya


  1. Inhibition of mammalian ribonucleotide reductase by a dinucleotide produced in eucaryotic cells. Lewis, W.H., McNaughton, D.R., Goh, S.H., LéJohn, H.B., Wright, J.A. J. Cell. Physiol. (1977) [Pubmed]
  2. Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. Manavathu, E.K., Suryanarayana, K., Hasnain, S.E., Leung, M., Lau, Y.F., Leung, W.C. Gene (1987) [Pubmed]
  3. Extension growth of the water mold Achlya: interplay of turgor and wall strength. Money, N.P., Harold, F.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Steroid hormone regulation of the Achlya ambisexualis 85-kilodalton heat shock protein, a component of the Achlya steroid receptor complex. Brunt, S.A., Riehl, R., Silver, J.C. Mol. Cell. Biol. (1990) [Pubmed]
  5. NADP(+)-activable, NAD(+)-specific glutamate dehydrogenase. Purification and immunological analysis. Yang, B., LéJohn, H.B. J. Biol. Chem. (1994) [Pubmed]
  6. The effects of environmental stress on steroid receptor levels and steroid-induced morphogenesis in Achlya ambisexualis. Riehl, R.M. Exp. Cell Res. (1988) [Pubmed]
  7. Heat-shock-induced changes in the phosphorylation of ribosomal and ribosome-associated proteins in the filamentous fungus Achlya ambisexualis. Pekkala, D., Silver, J.C. Exp. Cell Res. (1987) [Pubmed]
  8. Alterations in RNA and protein synthesis associated with steroid hormone-induced sexual morphogenesis in the water mold Achlya. Timberlake, W.E. Dev. Biol. (1976) [Pubmed]
  9. Cellular localization of steroid hormone-regulated proteins during sexual development in Achlya. Brunt, S.A., Silver, J.C. Exp. Cell Res. (1986) [Pubmed]
  10. A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold Achlya ambisexualis. Schowalter, D.B., Toft, D.O., Sommer, S.S. Genomics (1990) [Pubmed]
  11. Synthesis of dehydro-oogoniol, a female-activating hormone of Achlya: the progesterone route. McMorris, T.C., Le, P.H., Preus, M.W., Schow, S.R., Weihe, G.R. Steroids (1989) [Pubmed]
  12. A beta4 integrin-like protein co-localises with a phosphotyrosine containing protein in the oomycete Achlya bisexualis: inhibition of tyrosine phosphorylation slows tip growth. Chitcholtan, K., Garrill, A. Fungal Genet. Biol. (2005) [Pubmed]
  13. Differential uptake and metabolism of sitosterol and cholesterol by Achlya, Pythium, and Phytophthora species. Hendrix, J.W. Can. J. Microbiol. (1975) [Pubmed]
  14. Molecular cloning and characterization of two different cDNAs encoding the molecular chaperone Hsp90 in the oomycete Achlya ambisexualis. Brunt, S.A., Silver, J.C. Fungal Genet. Biol. (2004) [Pubmed]
  15. Regulation of two different hsp70 transcript populations in steroid hormone-induced fungal development. Silver, J.C., Brunt, S.A., Kyriakopoulou, G., Borkar, M., Nazarian-Armavil, V. Dev. Genet. (1993) [Pubmed]
  16. Molecular cloning and characterization of two distinct hsp85 sequences from the steroid responsive fungus Achlya ambisexualis. Brunt, S.A., Silver, J.C. Curr. Genet. (1991) [Pubmed]
  17. Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa. Techel, D., Häfker, T., Muschner, S., Reimann, M., Li, Y., Monnerjahn, C., Rensing, L. Biochim. Biophys. Acta (1998) [Pubmed]
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