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Chemical Compound Review

AG-K-19996     1-(2-diethylaminoethylamino)- 4...

Synonyms: KST-1A4158, KST-1A4159, AC1L4PVQ, CTK4G6144, AR-1A0341, ...
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Disease relevance of Hycanthone methanesulfonate


High impact information on Hycanthone methanesulfonate


Biological context of Hycanthone methanesulfonate

  • HMS produced positive, dose--response effects in in vitro tests, metaphase analysis, micronucleus test, and urine analysis, but not in the host-mediated assay [7].

Anatomical context of Hycanthone methanesulfonate


Associations of Hycanthone methanesulfonate with other chemical compounds


Analytical, diagnostic and therapeutic context of Hycanthone methanesulfonate


  1. Induction of hepatic neoplastic lesions in mice with a single dose of hycanthone methanesulfonate after partial hepatectomy. Tsuda, H., Sarma, D.S., Rajalakshmi, S., Zubroff, J., Farber, E., Batzinger, R.P., Cha, Y.N., Bueding, E. Cancer Res. (1979) [Pubmed]
  2. Hycanthone and its congeners as bacterial mutagens. Cook, T.M., Goldman, C.K. J. Bacteriol. (1975) [Pubmed]
  3. Molecular analysis of the TK locus in L5178Y large and small colony mouse lymphoma cell mutants induced by hycanthone methanesulfonate. el-Tarras, A., Dubins, J.S., Warner, J., Hoffman, C., Cobb, R.R. Mutat. Res. (1995) [Pubmed]
  4. Sex differences in micronucleus induction with hycanthone methanesulfonate in bone marrow cells of mice. Kliesch, U., Adler, I.D. Mutat. Res. (1992) [Pubmed]
  5. Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures. Blazak, W.F., Los, F.J., Rudd, C.J., Caspary, W.J. Mutat. Res. (1989) [Pubmed]
  6. High proportion of multi-locus deletions among hycanthone-induced X-linked recessive lethals in Drosophila melanogaster. Kramers, P.G., Schalet, A.P., Paradi, E., Huiser-Hoogteyling, L. Mutat. Res. (1983) [Pubmed]
  7. A combined testing protocol approach for mutagenicity testing. Connor, T.H., Meyne, J., Molina, L., Legator, M.S. Mutat. Res. (1979) [Pubmed]
  8. Detection of alkylating agents by the analysis of amino acid residues in hemoglobin and urine. 1. The in vivo and in vitro effects of ethyl methanesulfonate, methyl methanesulfonate, hycanthone methanesulfonate, and naltrexone. Truong, L., Ward, J.B., Legator, M.S. Mutat. Res. (1978) [Pubmed]
  9. Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. Horwitz, J.P., Massova, I., Wiese, T.E., Besler, B.H., Corbett, T.H. J. Med. Chem. (1994) [Pubmed]
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