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Gene Review

Ephx2  -  epoxide hydrolase 2, cytoplasmic

Mus musculus

Synonyms: AW106936, Bifunctional epoxide hydrolase 2, CEH, Eph2, SEH, ...
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Disease relevance of Ephx2

  • Using antibodies against rat liver cEH, 24 positive clones were picked upon colony blot screening of a pEX 1/E. coli POP 2136 expression library.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • Lipopolysaccharide-induced mortality, systemic hypotension, and histologically evaluated tissue injury were substantially diminished by administration of urea-based, small-molecule inhibitors of sEH to C57BL/6 mice [2].
  • Mammary gland transfer RNA's (tRNA'S) of CEH mice infected with mammary tumor virus were analyzed in the preneoplastic state and compared to tRNAs of virus-free C3Hf mice and another uninfected strain, C57BL/6, which is completely resistant to cancer [3].
  • In order to investigate the involvement of amino acids in the catalytic mechanism of the soluble epoxide hydrolase, different mutants of the murine enzyme were produced using the baculovirus expression system [4].
  • The temperature effect on the testicular CEH was demonstrated in vivo by assaying the enzyme following unilateral cryptorchidism [5].

High impact information on Ephx2


Biological context of Ephx2


Anatomical context of Ephx2


Associations of Ephx2 with chemical compounds


Regulatory relationships of Ephx2


Other interactions of Ephx2


Analytical, diagnostic and therapeutic context of Ephx2


  1. Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at level of protein and mRNA. Thomas, H., Schladt, L., Doehmer, J., Knehr, M., Oesch, F. Environ. Health Perspect. (1990) [Pubmed]
  2. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Schmelzer, K.R., Kubala, L., Newman, J.W., Kim, I.H., Eiserich, J.P., Hammock, B.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Analysis of the transfer RNA population of mouse mammary glands infected with a latent mammary tumor virus. Hentzen, D. Cancer Res. (1976) [Pubmed]
  4. Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase. Pinot, F., Grant, D.F., Beetham, J.K., Parker, A.G., Borhan, B., Landt, S., Jones, A.D., Hammock, B.D. J. Biol. Chem. (1995) [Pubmed]
  5. Temperature sensitivity of cholesteryl ester hydrolases in the rat testis. Durham, L.A., Grogan, W.M. Lipids (1982) [Pubmed]
  6. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Liu, Y., Zhang, Y., Schmelzer, K., Lee, T.S., Fang, X., Zhu, Y., Spector, A.A., Gill, S., Morisseau, C., Hammock, B.D., Shyy, J.Y. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Rapid purification of cytosolic epoxide hydrolase from normal and clofibrate-treated animals by affinity chromatography. Prestwich, G.D., Hammock, B.D. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  8. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Benson, A.M., Hunkeler, M.J., Talalay, P. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  9. Immunolocalization of a novel cholesteryl ester hydrolase in the endoplasmic reticulum of murine and human hepatocytes. Fresnedo, O., De Heredia, M.L., Martínez, M.J., Cristóbal, S., Rejas, M.T., Cuezva, J.M., Ochoa, B. Hepatology (2001) [Pubmed]
  10. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Hennebold, J.D., Mah, K., Perez, W., Vance, J.E., Stouffer, R.L., Morisseau, C., Hammock, B.D., Adashi, E.Y. Biol. Reprod. (2005) [Pubmed]
  11. Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. Sinal, C.J., Miyata, M., Tohkin, M., Nagata, K., Bend, J.R., Gonzalez, F.J. J. Biol. Chem. (2000) [Pubmed]
  12. Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. Simmons, D.L., Lalley, P.A., Kasper, C.B. J. Biol. Chem. (1985) [Pubmed]
  13. Molecular cloning and expression of murine liver soluble epoxide hydrolase. Grant, D.F., Storms, D.H., Hammock, B.D. J. Biol. Chem. (1993) [Pubmed]
  14. Epoxide metabolism in the liver of mice treated with clofibrate (ethyl-alpha-(p-chlorophenoxyisobutyrate], a peroxisome proliferator. Moody, D.E., Loury, D.N., Hammock, B.D. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  15. Organ distribution of epoxide hydrolases in cytosolic and microsomal fractions of normal and nafenopin-treated male DBA/2 mice. Waechter, F., Bentley, P., Bieri, F., Muakkassah-Kelly, S., Stäubli, W., Villermain, M. Biochem. Pharmacol. (1988) [Pubmed]
  16. In vitro translation of cytosolic and peroxisomal epoxide hydrolase and catalase on liver polyribosomes from untreated and clofibrate-treated C57B1/6 mice. Joste, V., Meijer, J. FEBS Lett. (1989) [Pubmed]
  17. Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Purification procedure and physiochemical characterization of the pure enzymes. Meijer, J., Depierre, J.W. Eur. J. Biochem. (1985) [Pubmed]
  18. Effects of hepatic inducers on testicular epoxide-metabolizing enzymes in the rat and mouse. DiBiasio, K.W., Silva, M.H., Hammock, B.D., Shull, L.R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1989) [Pubmed]
  19. Selective inhibition of cytosolic epoxide hydrolase activity in vitro by compounds that inhibit catalase. Guenthner, T.M., Hjelle, J.T., Whalen, R. J. Biochem. Toxicol. (1989) [Pubmed]
  20. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Jung, O., Brandes, R.P., Kim, I.H., Schweda, F., Schmidt, R., Hammock, B.D., Busse, R., Fleming, I. Hypertension (2005) [Pubmed]
  21. Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene. Grant, D.F., Spearow, J.L., Storms, D.H., Edelhoff, S., Adler, D.A., Disteche, C.M., Taylor, B.A., Hammock, B.D. Pharmacogenetics (1994) [Pubmed]
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