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Chemical Compound Review

Copper-67     copper

Synonyms: AC1L4ZUN, Copper, isotope of mass 67
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Disease relevance of copper


High impact information on copper


Associations of copper with other chemical compounds


Gene context of copper

  • Iodine-131, Yttrium-90, and Copper-67 labeled monoclonal antibodies targeting CD-20, CD-22, HLA class II, and other cell surface antigens have been tested and demonstrate higher overall response rates (50-80%) and complete response rates (20-40%) than unlabeled antibodies [11].

Analytical, diagnostic and therapeutic context of copper

  • After purification by gel filtration, the antibody-porphyrin conjugates were labeled with copper-67 in aqueous solution [12].
  • Copper-67-labeled Cu-PTSM was administered intravenously to four anesthetized dogs, followed c. 5 min later by a left ventricular injection of 85Sr-labeled microspheres (15 microns) to provide an independent measure of tumor perfusion [13].


  1. Cellular processing of copper-67-labeled monoclonal antibody chCE7 by human neuroblastoma cells. Novak-Hofer, I., Amstutz, H.P., Mäcke, H.R., Schwarzbach, R., Zimmermann, K., Morgenthaler, J.J., Schubiger, P.A. Cancer Res. (1995) [Pubmed]
  2. Copper-67 radioimmunotherapy and growth inhibition by anti-l1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis. Knogler, K., Grünberg, J., Zimmermann, K., Cohrs, S., Honer, M., Ametamey, S., Altevogt, P., Fogel, M., Schubiger, P.A., Novak-Hofer, I. Clin. Cancer Res. (2007) [Pubmed]
  3. Comparison of copper-67- and iodine-125-labeled anti-CEA monoclonal antibody biodistribution in patients with colorectal tumors. Delaloye, A.B., Delaloye, B., Buchegger, F., Vogel, C.A., Gillet, M., Mach, J.P., Smith, A., Schubiger, P.A. J. Nucl. Med. (1997) [Pubmed]
  4. Are radiometal-labeled antibodies better than iodine-131-labeled antibodies: comparative pharmacokinetics and dosimetry of copper-67-, iodine-131-, and yttrium-90-labeled Lym-1 antibody in patients with non-Hodgkin's lymphoma. DeNardo, G.L., DeNardo, S.J., O'Donnell, R.T., Kroger, L.A., Kukis, D.L., Meares, C.F., Goldstein, D.S., Shen, S. Clinical lymphoma. (2000) [Pubmed]
  5. Targeting superficial bladder cancer by the intravesical administration of copper-67-labeled anti-MUC1 mucin monoclonal antibody C595. Hughes, O.D., Bishop, M.C., Perkins, A.C., Wastie, M.L., Denton, G., Price, M.R., Frier, M., Denley, H., Rutherford, R., Schubiger, P.A. J. Clin. Oncol. (2000) [Pubmed]
  6. Radioimmunotherapy: recent results and future directions. Wilder, R.B., DeNardo, G.L., DeNardo, S.J. J. Clin. Oncol. (1996) [Pubmed]
  7. Tumor uptake and metabolism of copper-67-labeled monoclonal antibody chCE7 in nude mice bearing neuroblastoma xenografts. Novak-Hofer, I., Zimmermann, K., Maecke, H.R., Amstutz, H.P., Carrel, F., Schubiger, P.A. J. Nucl. Med. (1997) [Pubmed]
  8. Copper-67-labeled monoclonal antibody Lym-1, a potential radiopharmaceutical for cancer therapy: labeling and biodistribution in RAJI tumored mice. Deshpande, S.V., DeNardo, S.J., Meares, C.F., McCall, M.J., Adams, G.P., Moi, M.K., DeNardo, G.L. J. Nucl. Med. (1988) [Pubmed]
  9. Mouse brain synaptosomes accumulate copper-67 efficiently by two distinct processes independent of cellular prion protein. Giese, A., Buchholz, M., Herms, J., Kretzschmar, H.A. J. Mol. Neurosci. (2005) [Pubmed]
  10. Rhenium-188 and copper-67 radiopharmaceuticals for the treatment of bladder cancer. Frier, M. Mini reviews in medicinal chemistry. (2004) [Pubmed]
  11. Immunotherapy of Non-Hodgkin's lymphomas. Press, O.W., Leonard, J.P., Coiffier, B., Levy, R., Timmerman, J. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. (2001) [Pubmed]
  12. Preparation and characterization of copper-67 porphyrin-antibody conjugates. Roberts, J.C., Figard, S.D., Mercer-Smith, J.A., Svitra, Z.V., Anderson, W.L., Lavallee, D.K. J. Immunol. Methods (1987) [Pubmed]
  13. Evaluation of Cu-PTSM as a tracer of tumor perfusion: comparison with labeled microspheres in spontaneous canine neoplasms. Mathias, C.J., Green, M.A., Morrison, W.B., Knapp, D.W. Nucl. Med. Biol. (1994) [Pubmed]
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