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Chemical Compound Review

Rhenium-188     rhenium

Synonyms: AC1L4ZA7, 188Re, 14378-26-8, Rhenium, isotope of mass 188
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Disease relevance of rhenium


High impact information on rhenium

  • We have developed methods to target ionizing radiation to a fungal cell by labeling a specific mAb with the therapeutic radioisotopes Rhenium-188 and Bismuth-213 [6].
  • PURPOSE: We investigated the effect of repeated bone-targeted therapy with rhenium-188 hydroxyethylidenediphosphonate (HEDP) in patients with progressive, hormone-resistant prostate carcinoma and bone pain [7].
  • METHODS: In 68 male New Zealand White rabbits after endothelial denudation of the right common carotid artery with a Fogarty catheter, endovascular irradiation was performed with a Rhenium-188 filled 3.0-mm balloon catheter using different dosages (0, 7.5, 15, 30, 45 and 60 Gy at the surface of the vessel) [1].
  • Early effects of rhenium-188 treatment on proliferation, migration, and matrix synthesis of cultured human aortic smooth muscle cells [8].
  • Mixed-ligand rhenium-188 complexes with tetradentate/monodentate NS3/P ('4 + 1') coordination: relation of structure with antioxidation stability [9].

Chemical compound and disease context of rhenium


Biological context of rhenium


Anatomical context of rhenium


Associations of rhenium with other chemical compounds


Gene context of rhenium


Analytical, diagnostic and therapeutic context of rhenium


  1. Endovascular irradiation with the liquid beta-emitter Rhenium-188 to reduce restenosis after experimental wall injury. Wohlfrom, M., Kotzerke, J., Kamenz, J., Eble, M., Hess, B., Wöhrle, J., Reske, S.N., Hombach, V., Hanke, H., Höher, M. Cardiovasc. Res. (2001) [Pubmed]
  2. Pharmacokinetics, dosimetry and toxicity of rhenium-188-labeled anti-carcinoembryonic antigen monoclonal antibody, MN-14, in gastrointestinal cancer. Juweid, M., Sharkey, R.M., Swayne, L.C., Griffiths, G.L., Dunn, R., Goldenberg, D.M. J. Nucl. Med. (1998) [Pubmed]
  3. Intratumoral injection of rhenium-188 microspheres into an animal model of hepatoma. Wang, S.J., Lin, W.Y., Chen, M.N., Chi, C.S., Chen, J.T., Ho, W.L., Hsieh, B.T., Shen, L.H., Tsai, Z.T., Ting, G., Mirzadeh, S., Knapp, F.F. J. Nucl. Med. (1998) [Pubmed]
  4. Dose escalation study with rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases. Palmedo, H., Guhlke, S., Bender, H., Sartor, J., Schoeneich, G., Risse, J., Grünwald, F., Knapp, F.F., Biersack, H.J. European journal of nuclear medicine. (2000) [Pubmed]
  5. Rhenium-188 therapy of experimental hydrocephalus. Bardfeld, P.A., Shulman, K. Exp. Neurol. (1976) [Pubmed]
  6. Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection. Dadachova, E., Nakouzi, A., Bryan, R.A., Casadevall, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Repeated bone-targeted therapy for hormone-refractory prostate carcinoma: tandomized phase II trial with the new, high-energy radiopharmaceutical rhenium-188 hydroxyethylidenediphosphonate. Palmedo, H., Manka-Waluch, A., Albers, P., Schmidt-Wolf, I.G., Reinhardt, M., Ezziddin, S., Joe, A., Roedel, R., Fimmers, R., Knapp, F.F., Guhlke, S., Biersack, H.J. J. Clin. Oncol. (2003) [Pubmed]
  8. Early effects of rhenium-188 treatment on proliferation, migration, and matrix synthesis of cultured human aortic smooth muscle cells. Kehlbach, R., Dittmann, H., Schmid, T., Khorchidi, S., Bantleon, R., Rodemann, H.P., Claussen, C.D., Duda, S.H., Wiskirchen, J. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2006) [Pubmed]
  9. Mixed-ligand rhenium-188 complexes with tetradentate/monodentate NS3/P ('4 + 1') coordination: relation of structure with antioxidation stability. Schiller, E., Seifert, S., Tisato, F., Refosco, F., Kraus, W., Spies, H., Pietzsch, H.J. Bioconjug. Chem. (2005) [Pubmed]
  10. Application of rhenium-188 HEDP in bone metastases therapy. Scheffler, J., Derejko, M., Bandurski, T., Romanowicz, G. Nuclear medicine review. Central & Eastern Europe : journal of Bulgarian, Czech, Macedonian, Polish, Romanian, Russian, Slovak, Yugoslav societies of nuclear medicine and Ukrainian Society of Radiology. (2003) [Pubmed]
  11. Treatment of infection with radiolabeled antibodies. Dadachova, E., Casadevall, A. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceu... (2006) [Pubmed]
  12. Labelling of Re-ABP with 188Re for bone pain palliation. Arteaga de Murphy, C., Ferro-Flores, G., Pedraza-López, M., Meléndez-Alafort, L., Croft, B.Y., Ramírez, F.M., Padilla, J. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2001) [Pubmed]
  13. Rhenium-188 for inhibition of human aortic smooth muscle cell proliferation. Wiskirchen, J., Dittmann, H., Kehlbach, R., Vogel-Claussen, J., Gebert, R., Dohmen, B.M., Schöber, W., Bares, R., Rodemann, H.P., Claussen, C.D., Duda, S.H. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  14. Transport and distribution of rhenium-188 in the central nervous system. Bardfeld, P.A., Shulman, K. Exp. Neurol. (1976) [Pubmed]
  15. Biodistribution of rhenium-188 Lipiodol infused via the hepatic artery of rats with hepatic tumours. Wang, S.J., Lin, W.Y., Chen, M.N., Hsieh, B.T., Shen, L.H., Tsai, Z.T., Ting, G., Knapp, F.F. European journal of nuclear medicine. (1996) [Pubmed]
  16. Targeted bone marrow irradiation in the conditioning of high-risk leukaemia prior to stem cell transplantation. Reske, S.N., Bunjes, D., Buchmann, I., Seitz, U., Glatting, G., Neumaier, B., Kotzerke, J., Buck, A., Martin, H., Döhner, H., Bergmann, L. European journal of nuclear medicine. (2001) [Pubmed]
  17. Reduction of tissue hyperplasia with a rhenium-188 mercaptoacetyltriglycine-3-filled balloon: preliminary study in a canine urethral model. Shin, J.H., Song, H.Y., Moon, D.H., Oh, S.J., Kim, J.S., Kim, T.H., Choi, W.C., Suh, J.Y., Kang, W., Seol, H.Y., Lee, J.H. Journal of vascular and interventional radiology : JVIR. (2004) [Pubmed]
  18. Dosimetry of rhenium-188 diethylene triamine penta-acetic acid for endovascular intra-balloon brachytherapy after coronary angioplasty. Lee, J., Lee, D.S., Kim, K.M., Yeo, J.S., Cheon, G.J., Kim, S.K., Ahn, J.Y., Jeong, J.M., Chung, J.K., Lee, M.C. European journal of nuclear medicine. (2000) [Pubmed]
  19. Assessment of supra-additive effects of cytotoxic drugs and low dose rate irradiation in an in vitro model for hepatocellular carcinoma. Lambert, B., Ridder, L.D., Vos, F.D., Slegers, G., de Gelder, V., de Wiele, C.V., Thierens, H. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  20. Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells. Friesen, C., Lubatschofski, A., Kotzerke, J., Buchmann, I., Reske, S.N., Debatin, K.M. Eur. J. Nucl. Med. Mol. Imaging (2003) [Pubmed]
  21. Uptake of the 188Re(V)-DMSA complex by cervical carcinoma cells in nude mice: pharmacokinetics and dosimetry. García-Salinas, L., Ferro-Flores, G., Arteaga-Murphy, C., Pedraza-López, M., Hernández-Gutiérrez, S., Azorin-Nieto, J. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2001) [Pubmed]
  22. Management of multiple intrahepatic recurrences after radiofrequency ablation of hepatocellular carcinoma with rhenium-188-HDD-lipiodol. Kumar, A., Bal, C., Srivastava, D.N., Thulkar, S.P., Sharma, S., Acharya, S.K., Duttagupta, S. European journal of gastroenterology & hepatology. (2006) [Pubmed]
  23. Expression profile of vascular cell adhesion molecule-1 (CD106) in inflammatory foci using rhenium-188 labelled monoclonal antibody in mice. Kairemo, K.J., Strömberg, S., Nikula, T.K., Karonen, S.L. Cell Adhes. Commun. (1998) [Pubmed]
  24. Gastrin-releasing peptide (GRP) analogues for cancer imaging. Varvarigou, A., Bouziotis, P., Zikos, C., Scopinaro, F., De Vincentis, G. Cancer Biother. Radiopharm. (2004) [Pubmed]
  25. 188Re-labeled anti-epidermal growth factor receptor humanized monoclonal antibody h-R3: labeling conditions, in vitro and in vivo stability. Iznaga-Escobar, N., Ramirez, I.L., Izquierdo, J.C., Suárez, L., Morales, D., Pérez-Rodríguez, R. Methods and findings in experimental and clinical pharmacology. (2003) [Pubmed]
  26. Direct radiolabeling of monoclonal antibodies with generator-produced rhenium-188 for radioimmunotherapy: labeling and animal biodistribution studies. Griffiths, G.L., Goldenberg, D.M., Knapp, F.F., Callahan, A.P., Chang, C.H., Hansen, H.J. Cancer Res. (1991) [Pubmed]
  27. Rhenium-188 hydroxyethylidene diphosphonate: a new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases. Lin, W.Y., Lin, C.P., Yeh, S.J., Hsieh, B.T., Tsai, Z.T., Ting, G., Yen, T.C., Wang, S.J., Knapp, F.F., Stabin, M.G. European journal of nuclear medicine. (1997) [Pubmed]
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