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Chemical Compound Review

CHEMBL36743     2,5-diamino-2-methyl-pentanoic acid

Synonyms: AGN-PC-00O0ZL, CHEBI:158119, AR-1E4083, LS-175078, AKOS006347210, ...
 
 
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Disease relevance of DL-alpha-Methylornithine

 

High impact information on DL-alpha-Methylornithine

 

Anatomical context of DL-alpha-Methylornithine

 

Associations of DL-alpha-Methylornithine with other chemical compounds

 

Gene context of DL-alpha-Methylornithine

References

  1. Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells. Seidenfeld, J., Marton, L.J. Cancer Res. (1980) [Pubmed]
  2. Mechanism of inactivation of ornithine decarboxylase by alpha-methylornithine. O'Leary, M.H., Herreid, R.M. Biochemistry (1978) [Pubmed]
  3. Ornithine and glutamate decarboxylases catalyse an oxidative deamination of their alpha-methyl substrates. Bertoldi, M., Carbone, V., Borri Voltattorni, C. Biochem. J. (1999) [Pubmed]
  4. Cytocidal effect of alpha-methylornithine, a competitive inhibitor of ornithine decarboxylase, on ehrlich ascites tumor cells in vivo. Linden, M., Oredsson, S., Heby, O. Cancer Lett. (1980) [Pubmed]
  5. Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by alpha-difluoromethylornithine. Isom, H.C., Pegg, A.E. Biochim. Biophys. Acta (1979) [Pubmed]
  6. Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of alpha-methylornithine and methylglyoxal bis(guanylhydrazone). Morris, D.R., Jorstad, C.M., Seyfried, C.E. Cancer Res. (1977) [Pubmed]
  7. Activation of ADP-ribosyltransferase in polyamine-depleted mammalian cells. Wallace, H.M., Gordon, A.M., Keir, H.M., Pearson, C.K. Biochem. J. (1984) [Pubmed]
  8. Dissociation of tumour-promoter-induced effects on prostaglandin release, polyamine synthesis and cell proliferation of 3T3 cells. Lanz, R., Brune, K. Biochem. J. (1981) [Pubmed]
  9. Induction of polyamine limitation in Chinese hamster ovary cells by alpha-methylornithine. Harada, J.J., Porter, C.W., Morris, D.R. J. Cell. Physiol. (1981) [Pubmed]
  10. The utilization of an inhibitor of spermidine and spermine synthesis as a tool for the study of the determination of cavitation in the preimplantation mouse embryo. Alexandre, H. Journal of embryology and experimental morphology. (1979) [Pubmed]
  11. Behavioural and electrocortical effects after injection of two ornithine decarboxylase inhibitors into several areas of the brain in the rat. De Sarro, G.B., Ascioti, C., Audino, M.G., Libri, V., De Sarro, A., Nisticò, G. Neuropharmacology (1989) [Pubmed]
  12. Effects of various ammonium salts, amines, polyamines and alpha-methylornithine on rRNA synthesis in neurula cells of Xenopus laevis and Xenopus borealis. Shiokawa, K., Kawazoe, Y., Tashiro, K., Yamana, K. Cell Differ. (1986) [Pubmed]
 
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