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Gene Review

odc1  -  ornithine decarboxylase 1

Xenopus (Silurana) tropicalis

Synonyms: odc, odc2, xODC1, xodc2
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High impact information on odc1


Biological context of odc1


Anatomical context of odc1


Associations of odc1 with chemical compounds

  • All the ammonium salts and amines, but not polyamines, were strong and selective inhibitors of rRNA synthesis at 1.25-5.0 mM. alpha-Methylornithine did not inhibit rRNA synthesis, although it inhibited ornithine decarboxylase, an enzyme claimed to be a direct stimulator of rRNA synthesis [6].

Analytical, diagnostic and therapeutic context of odc1

  • This study has utilized stage VI oocytes of Xenopus laevis which have amplified the rDNA gene 1,000-fold to assess whether the microinjection of ornithine decarboxylase (OrnDCase) would stimulate [alpha-32P]guanosine incorporation into 45S and 18S/28S RNA selectively [2].


  1. Depletion of intracellular polyamines relieves inward rectification of potassium channels. Shyng, S.L., Sha, Q., Ferrigni, T., Lopatin, A.N., Nichols, C.G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Microinjection of purified ornithine decarboxylase into Xenopus oocytes selectively stimulates ribosomal RNA synthesis. Russell, D.H. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  3. Expression and post-transcriptional regulation of ornithine decarboxylase during early Xenopus development. Osborne, H.B., Duval, C., Ghoda, L., Omilli, F., Bassez, T., Coffino, P. Eur. J. Biochem. (1991) [Pubmed]
  4. Down-regulation of ornithine decarboxylase by an increased degradation of the enzyme during gastrulation of Xenopus laevis. Rosander, U., Holm, I., Grahn, B., Løvtrup-Rein, H., Mattsson, M.O., Heby, O. Biochim. Biophys. Acta (1995) [Pubmed]
  5. Presence of ornithine decarboxylase antizyme in primary cultured hepatocytes of the frog Xenopus laevis. Baby, T.G., Hayashi, S. Biochim. Biophys. Acta (1991) [Pubmed]
  6. Effects of various ammonium salts, amines, polyamines and alpha-methylornithine on rRNA synthesis in neurula cells of Xenopus laevis and Xenopus borealis. Shiokawa, K., Kawazoe, Y., Tashiro, K., Yamana, K. Cell Differ. (1986) [Pubmed]
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