Disease relevance of Ba 2758

• The following observations showed that 2-deoxy-D-galactose is a useful tool for the isolation and elucidation of the activity of one system for galactose uptake into Escherichia coli [1].
• The metabolism of 2-deoxy-D-galactose has been studied in AS-30D rat ascites hepatoma cells in suspension [2].
• 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition [2].
• 2-Deoxy-D-galactose impairs the fucosylation of glycoproteins of rat liver and Morris hepatoma [3].
• Streptomyces coelicolor A3(2) and Streptomyces lividans 66 strains were shown to be sensitive to the galactose analogue 2-deoxy-D-galactose [4].

Psychiatry related information on Ba 2758

• 2-Deoxy-D-galactose caused amnesia for the passive avoidance task when injected before training into the right hemisphere but not the left [5].

High impact information on Ba 2758

• The incorporation of 2-deoxy-D-galactose into the oligosaccharide moieties of glycoproteins and the consequences of 2-deoxy-D-galactose treatment on the fucosylation of glycoproteins were investigated in the human hepatoma cell line HepG2 [6].
• The rate of phosphorylation of 2-deoxy-D-galactose was rapid during the first 30 min and decreased to approximately 20% of this rate during the subsequent hours [2].
• Interruption of Pi trapping by removal of 2-deoxy-D-galactose from the medium reversed the depressions of Pi and ATP and resulted in a rapid but incomplete relief of glycolysis inhibition [2].
• The quantitative analysis of the metabolites of 2-deoxy-D-galactose demonstrated the predominance of the monophosphate and the negligible formation of UPD derivatives of this sugar analog in AS-30D hepatoma cells [2].
• Cell survival after heating was not increased by two sugars: (a) D-idose, and (b) 2-deoxy-D-galactose [7].

Biological context of Ba 2758

• 2-Deoxy-D-galactose (dGal) transport in Saccharomyces fragilis is characterized by energy requirement and accumulation of the free sugar against a concentration gradient, indicating active transport [8].

Anatomical context of Ba 2758

• Hepatocytes of 2-deoxy-D-galactose-treated rats showed a dissociation and fragmentation of the rough endoplasmic reticulum [9].
• Phosphate trapping was caused by the rapid accumulation of 2-deoxy-D-galactose 1-phosphate and was most pronounced in liver but also demonstrated in small intestine, brain, spleen, and thymus [9].

Associations of Ba 2758 with other chemical compounds

• The structural specificity of the transport of 0.5 mM D-galactose and 2-deoxy-D-galactose by teased renal tubules of the winter flounder Pseudopleuronectes americanus was investigated [10].
• Active transport of L-sorbose and 2-deoxy-D-galactose in Saccharomyces fragilis [11].

Analytical, diagnostic and therapeutic context of Ba 2758

• The intraventricular injection of 2-deoxy-D-galactose led to a dose- and time-dependent decrease in the fucosylation of hippocampal glycoproteins in rats whereas the incorporation of 3H-N-acetyl-glucosamine was not influenced [12].

References