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Chemical Compound Review:

Calcium diphosphate dicalcium dioxido-oxo-phosphonatooxy...

Synonyms: ACMC-1BM10, AG-H-12421, CHEBI:32598, HSDB 1435, AC1L2NKJ, ...

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Disease relevance of Calcium diphosphate

Among the irritants that may be used, we focused our interest on calcium pyrophosphate (CaPP) crystals, a non-diffusible, non-antigenic and endotoxin-free irritant, because their deposition is implicated in pseudogout and chondrocalcinosis in man (MacCarty, 1973) [1].
In all cases a dose-dependent inhibition of chemotaxis was observed, more striking in the case of CaPP elicited cells which were more reactive than cells collected after the induction of the Arthus reaction [2].
The effect of piroxicam on rat polymorphonuclear leucocytes (PMN) has been studied in vitro and in vivo after the induction of two acute, non specific inflammatory reactions (pleurisies induced by calcium pyrophosphate crystals (CaPP) or isologous serum) [3].

High impact information on Calcium diphosphate

RESULTS: Increased SF 3-B-3 concentrations and 3-B-3/GAG ratio were found in OA, compared with RA or normal knees, with higher 3-B-3 and 3-B-3/GAG in LJOA and NGOA than in CPA [4].
On the other hand, Flurbiprofen reduced both random and directed locomotion of CaPP-elicited PMN stimulated with peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), isologous rat serum (IRS) or cell-free exudates [5].
A case of cervical myeloradiculopathy secondary to deposits of calcium pyrophosphate dihydrate (Ca2P2O7 2H2O) (CPPD) crystals in the degenerating ligamentum flavum, with marked granulomatous inflammation, is presented [6].
X-ray diffraction and IR spectroscopy showed that they are made entirely of beta pyrophosphate (Ca2P2O7), a result in agreement with previous chemical analysis [7].
The drug was administered in vivo or tested in vitro on polymorphonuclears collected in the pleural cavity after induction of an immune (reverse passive Arthus reaction) or an acute non-specific inflammation (pleurisy induced by a suspension) (1%) of calcium pyrophosphate crystals (CaPP) [2].

Biological context of Calcium diphosphate

An inhibition of random cell migration has been observed only at the higher drug concentration using agarose assay with CaPP-elicited cells [3].

Anatomical context of Calcium diphosphate

PMNs, collected from the pleural cavity of rats 4 hours after injection of either calcium pyrophosphate (CaPP) or normal plasma, released into the supernatant culture fluid, factors which enhanced the phytohaemagglutinin-induced proliferative response of normal lymph node cells or thymocytes, the optimal culture time being 24 hours [8].
Thus these results demonstrate that the acute inflammatory reaction, initiated by a non-antigenic stimulus ( CaPP ), is able to stimulate macrophages remote from the inflammatory site to produce a factor which behaves like LAF in a standard LAF assay [9].
Peritoneal macrophages harvested from animals undergoing an acute non-immunological inflammatory reaction induced by an injection of calcium pyrophosphate ( CaPP ) or dextran into the pleural cavity showed an enhanced level of production of a lymphocyte activating factor (LAF) like material [9].
MATERIALS AND METHODS: Two milligrams of dicalcium pyrophosphate crystals (DCPP) were injected in both joints of the lower limbs of rats during 2 days [10].

Associations of Calcium diphosphate with other chemical compounds

Crystal deposits were identified as calcium pyrophosphate dihydrate (Ca2P2O7 X 2H2O) by means of X-ray diffraction [11].
An enzyme immunoassay was used to measure the levels of bradykinin (BK)-like immunoreactivity in inflammatory exudates provoked by calcium pyrophosphate (CaPP) or carrageenin [12].

Gene context of Calcium diphosphate

CONCLUSION: He-Ne laser treatment in the microcrystalline arthropathy induced in rats by DCPP injection might have an antiinflammatory effect, evaluated by fibrinogen plasma levels and TNF-alpha (inflammatory markers) and by the histopathology regressive process [10].

References

Acute non-specific inflammation and modification of macrophage and lymphocyte functions. Giroud, J.P., Sheng, Y.C., Pelletier, M., Florentin, I., Bird, J. Br. J. Dermatol. (1983) [Pubmed]
Effect of piroxicam on the chemotaxis and random migration of polymorphonuclear leucocytes after induction of immune and non immune inflammations. Pham-Huy, D., Roch-Arveiller, M., Lenoir, M., Muntaner, O., Giroud, J.P. Biomed. Pharmacother. (1985) [Pubmed]
In vitro and in vivo effects of piroxicam on rat polymorphonuclear responsiveness after induction of two acute non-specific inflammatory reactions. Huy, D.P., Roch-Arveiller, M., Lenoir, M., Muntaner, O., Thuret, A., Giroud, J.P. Agents Actions (1986) [Pubmed]
Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees. Belcher, C., Yaqub, R., Fawthrop, F., Bayliss, M., Doherty, M. Ann. Rheum. Dis. (1997) [Pubmed]
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen. Perianin, A., Roch-Arveiller, M., Giroud, J.P., Hakim, J. Biochem. Pharmacol. (1984) [Pubmed]
Myeloradiculopathy secondary to pseudogout in the cervical ligamentum flavum: case report. Gomez, H., Chou, S.M. Neurosurgery (1989) [Pubmed]
Preparation and characterization of new hybrid organic/inorganic systems derived from calcium (alpha-aminoalkyl)-phosphonates and -phosphonocarboxylates. Al-Ali, F., Lebugle, A., Rico-Lattes, I., Etemad-Moghadam, G. Journal of colloid and interface science. (2005) [Pubmed]
Rat and human polymorphonuclear leukocyte derived lymphocyte stimulatory factors. Sheng, Y.J., Bird, J., Pompidou, A., Florentin, I., Giroud, J.P. Biomed. Pharmacother. (1984) [Pubmed]
Direct and indirect in vivo stimulation of LAF-like production induced by acute nonspecific inflammatory processes. Sheng, Y.J., Florentin, I., Bird, J., Pelletier, M., Damais, C., Parant, M., Giroud, J.P. Int. J. Immunopharmacol. (1984) [Pubmed]
He-Ne laser on microcrystalline arthropathies. Campana, V., Moya, M., Gavotto, A., Simes, J.C., Spitale, L., Soriano, F., Palma, J.A. Journal of clinical laser medicine & surgery. (2003) [Pubmed]
Rhesus monkeys (Macaca mulatta) as a model for calcium pyrophosphate dihydrate crystal deposition disease. Renlund, R.C., Pritzker, K.P., Cheng, P.T., Kessler, M.J. J. Med. Primatol. (1986) [Pubmed]
Bradykinin levels in inflammatory exudates. Tissot, M., Regoli, D., Giroud, J.P. Inflammation (1985) [Pubmed]

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