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Chemical Compound Review

NSC-77009     [2,3,4-trihydroxy-5-[(3,4,5...

Synonyms: AC1L5OTZ, NSC77009
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High impact information on NSC77009


Biological context of NSC77009


Anatomical context of NSC77009


Associations of NSC77009 with other chemical compounds

  • Catechin and a low-molecular weight proanthocyandin fraction (W(M)) caused only slight increases of OTM up to concentrations of 166 microg/ml whereas hamamelitannin and the proanthocyandin fraction with higher molecular weight (W(A)) led to a two-fold enhancement of OTM at the same concentrations [5].
  • Previously we demonstrated that hamamelitannin (2',5-di-O-galloyl hamamelose) in Hamamelis virginiana L. exhibits potent superoxide-anion scavenging activity [6].

Gene context of NSC77009

  • The observed anti-TNF activity of hamamelitannin may explain the antihamorrhaegic use of H. virginiana in traditional medicine and its claimed use as a protective agent for UV radiation [4].
  • (4) When hamamelitannin was treated with superoxide anions generated by a KO2-crown ether system, HPLC analysis showed the disappearance of hamamelitannin and the concomitant formation of hamamelitannin-derived radicals (g = 2.005, delta H1 = 2.16 G, delta H2 = 4.69 G) was detected by ESR spectrometry.(ABSTRACT TRUNCATED AT 250 WORDS)[6]

Analytical, diagnostic and therapeutic context of NSC77009


  1. Dual inhibitory activities of tannins from Hamamelis virginiana and related polyphenols on 5-lipoxygenase and lyso-PAF: acetyl-CoA acetyltransferase. Hartisch, C., Kolodziej, H., von Bruchhausen, F. Planta Med. (1997) [Pubmed]
  2. Peroxyl radical scavenging activities of hamamelitannin in chemical and biological systems. Masaki, H., Atsumi, T., Sakurai, H. Free Radic. Res. (1995) [Pubmed]
  3. Tannins from Hamamelis virginiana: Identification of Proanthocyanidins and Hamamelitannin Quantification in Leaf, Bark, and Stem Extracts. Vennat, B., Pourrat, H., Pouget, M.P., Gross, D., Pourrat, A. Planta Med. (1988) [Pubmed]
  4. Hamamelitannin from Hamamelis virginiana inhibits the tumour necrosis factor-alpha (TNF)-induced endothelial cell death in vitro. Habtemariam, S. Toxicon (2002) [Pubmed]
  5. Genotoxic and antigenotoxic effects of catechin and tannins from the bark of Hamamelis virginiana L. in metabolically competent, human hepatoma cells (Hep G2) using single cell gel electrophoresis. Dauer, A., Hensel, A., Lhoste, E., Knasmüller, S., Mersch-Sundermann, V. Phytochemistry (2003) [Pubmed]
  6. Protective activity of hamamelitannin on cell damage induced by superoxide anion radicals in murine dermal fibroblasts. Masaki, H., Atsumi, T., Sakurai, H. Biol. Pharm. Bull. (1995) [Pubmed]
  7. Determination of hamamelitannin, catechins and gallic acid in witch hazel bark, twig and leaf by HPLC. Wang, H., Provan, G.J., Helliwell, K. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
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