Disease relevance of Cionin

• Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis [1].

High impact information on Cionin

• Cionin, isolated from Ciona intestinalis, a representative of the protochordates that occupy a key position at the transition to vertebrates, so far represents the oldest genuine member of the CCK/gastrin family, dating the emergence of these peptides back to at least 500 million years ago [2].
• Cionin, a peptide showing similarities with cholecystokinin and gastrin has been shown to be expressed in the gut and neural ganglion of the protochordate Ciona intestinalis [3].
• Hence, the tissue-specific expression of the cionin gene in Ciona intestinalis resembles that of the CCK gene in mammals [4].
• The 5'-donor and 3'-acceptor splice sites found in the cionin gene, however, are in agreement with the mammalian consensus sequence [5].
• Stimulation of rainbow trout gallbladder contraction by cionin, an ancestral member of the CCK/gastrin family [6].

Anatomical context of Cionin

• Stimulation by the ancestral member of the CCK/gastrin family, cionin, of trout gallbladder contraction [7].
• Cionin and mono-Tyr(SO3H)-containing derivatives were assayed on exocrine pancreas in dogs [8].

Associations of Cionin with other chemical compounds

• This study examined a phylogenetically ancient CCK receptor, the rainbow trout (Oncorhynchus mykiss) gallbladder receptor, utilizing cionin, sulfated and nonsulfated CCK and gastrin, and the receptor antagonists L-364,718 and L-365,260 [6].

Gene context of Cionin

• Sulphated CCK-7, CCK-8, and cionin apparent binding affinities were not affected [9].
• BACKGROUND: The protochordean octapeptide cionin is structurally a hybrid of mammalian cholecystokinin (CCK) and gastrin [10].
• An earlier study has shown that cionin in mammals stimulates gallbladder contraction and gastric somatostatin release, similarly to CCK-8 [10].
• The results show that cionin behaves like CCK rather than gastrin in mammals [11].
• To determine whether cionin behaves like CCK or gastrin, we examined its effect on canine fundic somatostatin cells and on porcine and bovine gallbladder muscles [11].

Analytical, diagnostic and therapeutic context of Cionin

• Molecular cloning of a putative Ciona intestinalis cionin receptor, a new member of the CCK/gastrin receptor family [3].
• Part of the gene encoding cionin from the protochordate Ciona intestinalis was amplified by polymerase chain reaction from genomic DNA employing synthetic oligonucleotides designed from the reported cDNA sequence [5].

References