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Chemical Compound Review

AGN-PC-0006HI     2,3,4,5-tetrahydroxy-6- phosphonooxy...

Synonyms: NSC-316735, AC1Q6RYD, NSC316735, AR-1H2466, AC1L1974, ...
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Disease relevance of CPD-2961


High impact information on CPD-2961

  • The inhibition constant (Ki) for 6-phosphogluconate (6-P-gluconate) was pH dependent [2].
  • The antiserum to 6-phospho-gluconate dehydrogenase was absorbed with a tissue extract from an early stage in mammary-gland differentiation [3].
  • Using a combination of knockout mutations in known and putative genes of the oxidative PP pathway and 13C-labeling experiments, we demonstrated that yqjI encodes the NADP+-dependent 6-P-gluconate dehydrogenase, as was hypothesized previously from sequence similarities [1].
  • Exposure significantly enhanced catalase and 6-P-gluconate dehydrogenase activities, but not other antioxidative enzymes [4].
  • 7. In homogenates of the inner medulla the activity of 6-phospho-gluconate dehydrogenase (EC was identical in both experimental groups, so the pentose phosphate shunt seems to be unaltered [5].

Anatomical context of CPD-2961


Associations of CPD-2961 with other chemical compounds


Gene context of CPD-2961


Analytical, diagnostic and therapeutic context of CPD-2961

  • A phylogenetic tree based on sequence analyses showed higher homology of 6-phospho-gluconate dehydrogenase of A. actinomycetemcomitans with the eucaryotic enzymes rather than with bacterial enzymes [10].


  1. The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway. Zamboni, N., Fischer, E., Laudert, D., Aymerich, S., Hohmann, H.P., Sauer, U. J. Bacteriol. (2004) [Pubmed]
  2. The isozymes of glucose-phosphate isomerase (GPI-A2 and GPI-B2) from the teleost fish Fundulus heteroclitus (L.). Van Beneden, R.J., Powers, D.A. J. Biol. Chem. (1985) [Pubmed]
  3. Absorption of antisera for studies on specific enzyme turnover. Walker, J.H., Betts, S.A., Manning, R., Mayer, R.J. Biochem. J. (1976) [Pubmed]
  4. Uptake and clearance of PCB congeners in Chamaelea gallina: response of oxidative stress biomarkers. Rodríguez-Ariza, A., Rodríguez-Ortega, M.J., Marenco, J.L., Amezcua, O., Alhama, J., López-Barea, J. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2003) [Pubmed]
  5. Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction. Grunewald, R.W., Weber, I.I., Kinne-Saffran, E., Kinne, R.K. Biochim. Biophys. Acta (1993) [Pubmed]
  6. Effect of irradiation on electrophoretic properties of enzymes in haemopoietic cells of opossum. Prasad, N., Prasad, R., Bushong, S.C., North, L.B. Experientia (1977) [Pubmed]
  7. Control by phospho-adenosinediphospho-ribose of NADP-dependent isocitrate dehydrogenase and 6-phosphogluconate dehydrogenase in Streptomyces griseus. Gräfe, U., Bormann, E.J., Truckenbrodt, G. Z. Allg. Mikrobiol. (1980) [Pubmed]
  8. Regulation of pyruvate kinase by 6-phosphogluconate in isolated hepatocytes. Smith, S.B., Freedland, R.A. Am. J. Physiol. (1981) [Pubmed]
  9. Serum factors and red cell enzymes in Carib and Arowak Indians from Surinam. Geerdink, R.A., Okhura, K., Li Fo Sjoe, E., Schillhorn van Veen, J.M., Bartstra, H.A. Tropical and geographical medicine. (1975) [Pubmed]
  10. The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA. Yoshida, Y., Nakano, Y., Yamashita, Y., Koga, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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