Disease relevance of Suriname

• AIMS/HYPOTHESIS: We aimed to investigate the risk of end-stage diabetic nephropathy due to Type II (non-insulin-dependent) diabetes mellitus in Indo-Asian immigrants from Surinam [1].
• METHODS: DNA samples from 74 formalin-fixed paraffin-embedded HPV 16-positive cervical carcinomas from Indonesia (Java, N = 22), Suriname (N = 25), and The Netherlands (N = 27) were amplified using primers specific for the E6, E7, and part of the L1 regions [2].
• By means of the polymerase chain reaction two participants (male intravenous drug users infected with human immunodeficiency virus; HIV) appeared to be infected with HTLV-I and one subject (a male nonintravenous drug user from Surinam) with HTLV-II [3].
• Three different hemoglobinopathies, i.e. Hb S, Hb Chad [alpha 23 (B4)Glu----Lys], and alpha-thalassemia-2 (-3.7) have been observed in eight members of a family from Surinam [4].

High impact information on Suriname

• Samples of venous blood from 239 male and 476 female adults including 41 pairs of parents and 123 of their children belonging to a Surinam population called the Djuka or Bush Negroes of West African origin were screened for electrophoretic variants of red cell glutathione peroxidase (GPX1) in Cellogel [5].
• For Surinam, 150 negative, 50 Atypical Squamous Cells of Undetermined Significance, and 150 Squamous Intraepithelial Lesion smears were evaluated by polymerase chain reaction [6].
• Mean serum total cholesterol concentrations were low in the groups from Africa (3.0-4.3 mmol/liter; 1 mmol/liter = 38.7 mg/100 ml), intermediate in the groups from Pakistan, the Philippines, Surinam, Hungary, Poland, and the Mediterranean countries (4.4-5.5 mmol/liter), and high in those from the Netherlands and Finland (5.6- 6.4 mmol/liter) [7].
• New eudesmane derivatives from Melampodium camphoratum from the Suriname rainforest [8].
• This study is aimed at determining whether a commercially available varnish, containing 40% chlorhexidine, is able to reduce the numbers of mutans streptococci and lactobacilli in saliva, in a moderately caries-active population in Surinam [9].

Biological context of Suriname

• Electrotypes and formal genetics of red cell glutathione peroxidase (GPX1) in the Djuka of Surinam [5].

Associations of Suriname with chemical compounds

• Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname rainforest [10].
• Therefore, a study was performed to explore aluminium exposure in employees involved in this bauxite mining process in a Surinam mine [11].
• Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest [12].
• Sera of 98 participants in a methadone maintenance programme, all recent Surinam emigrants to the Netherlands, were examined for antibodies to disrupted HTLV using the ELISA technique [13].
• The use of wide-mesh gauze impregnated with lambda-cyhalothrin covering wall openings in huts as a vector control method in Suriname [14].

Gene context of Suriname

• The results of the electrophoretic phenotyping of some genetic markers (haptoglobin, group specific component, transferrin, haemoglobin, glucose-6-phosphate dehydrogenase and 6-phospho-gluconate dehydrogenase) in two tribal Indian populations from Surinam are presented [15].
• Sera of 26 control Dutch drug users lacked such antibodies with the exception of one female who subsequently was found to reside with a Surinam male [13].
• Estimating mortality from two censuses: an application to the Trio of Surinam [16].
• Hb Chad or alpha 223(B4)Glu----Lys beta 2 observed in members of a Surinam family in association with alpha-thalassemia-2 and with Hb S [4].
• Behavioral responses of Anopheles darlingi in Suriname to DDT residues on house walls [17].

References