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Chemical Compound Review

Glutaryl-7-aca     (6R,7S)-3-(acetyloxymethyl)- 7-(4...

Synonyms: SureCN569055, Gl-7-Aca, AG-E-89184, CHEBI:41425, AC1L9JTQ, ...
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Disease relevance of Gl-7-Aca


High impact information on Gl-7-Aca


Chemical compound and disease context of Gl-7-Aca


Biological context of Gl-7-Aca


Associations of Gl-7-Aca with other chemical compounds


Gene context of Gl-7-Aca

  • Following the complete conversion of a 75 mM solution of CefC into glutaryl-7-ACA catalyzed by an immobilized D-amino acid oxidase (DAAO), immobilized GA was used for the transformation of this intermediate into the final product 7-ACA [11].

Analytical, diagnostic and therapeutic context of Gl-7-Aca


  1. Improving the activity and stability of GL-7-ACA acylase CA130 by site-directed mutagenesis. Zhang, W., Liu, Y., Zheng, H., Yang, S., Jiang, W. Appl. Environ. Microbiol. (2005) [Pubmed]
  2. Cloning and nucleotide sequencing of a novel 7 beta-(4-carboxybutanamido)cephalosporanic acid acylase gene of Bacillus laterosporus and its expression in Escherichia coli and Bacillus subtilis. Aramori, I., Fukagawa, M., Tsumura, M., Iwami, M., Ono, H., Kojo, H., Kohsaka, M., Ueda, Y., Imanaka, H. J. Bacteriol. (1991) [Pubmed]
  3. Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit. Otten, L.G., Sio, C.F., Vrielink, J., Cool, R.H., Quax, W.J. J. Biol. Chem. (2002) [Pubmed]
  4. Active site residues of cephalosporin acylase are critical not only for enzymatic catalysis but also for post-translational modification. Kim, S., Kim, Y. J. Biol. Chem. (2001) [Pubmed]
  5. J1 acylase, a glutaryl-7-aminocephalosporanic acid acylase from Bacillus laterosporus J1, is a member of the alpha/beta-hydrolase fold superfamily. Yau, M.H., Wang, J., Tsang, P.W., Fong, W.P. FEBS Lett. (2006) [Pubmed]
  6. Evolution of an acylase active on cephalosporin C. Pollegioni, L., Lorenzi, S., Rosini, E., Marcone, G.L., Molla, G., Verga, R., Cabri, W., Pilone, M.S. Protein Sci. (2005) [Pubmed]
  7. A single amino acid substitution converts gamma-glutamyltranspeptidase to a class IV cephalosporin acylase (glutaryl-7-aminocephalosporanic acid acylase). Suzuki, H., Miwa, C., Ishihara, S., Kumagai, H. Appl. Environ. Microbiol. (2004) [Pubmed]
  8. Crystallization and preliminary X-Ray diffraction analysis of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas sp. GK16. Kwon, T.H., Rhee, S., Lee, Y.S., Park, S.S., Kim, K.H. J. Struct. Biol. (2000) [Pubmed]
  9. Analysis of a substrate specificity switch residue of cephalosporin acylase. Sio, C.F., Otten, L.G., Cool, R.H., Quax, W.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Production of D-amino acid oxidase (DAO) of Trigonopsis variabilis in Schizosaccharomyces pombe and the characterization of biocatalysts prepared with recombinant cells. Isoai, A., Kimura, H., Reichert, A., Schörgendorfer, K., Nikaido, K., Tohda, H., Giga-Hama, Y., Mutoh, N., Kumagai, H. Biotechnol. Bioeng. (2002) [Pubmed]
  11. Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase. Monti, D., Carrea, G., Riva, S., Baldaro, E., Frare, G. Biotechnol. Bioeng. (2000) [Pubmed]
  12. Reversible immobilization of glutaryl acylase on sepabeads coated with polyethyleneimine. Alonso-Morales, N., López-Gallego, F., Betancor, L., Hidalgo, A., Mateo, C., Fernández-Lafuente, R., Guisán, J.M. Biotechnol. Prog. (2004) [Pubmed]
  13. Fusion protein of Vitreoscilla hemoglobin with D-amino acid oxidase enhances activity and stability of biocatalyst in the bioconversion process of cephalosporin C. Khang, Y.H., Kim, I.W., Hah, Y.R., Hwangbo, J.H., Kang, K.K. Biotechnol. Bioeng. (2003) [Pubmed]
  14. Immobilization of glutaryl-7-aminocephalosporanic acid acylase on silica gel and enhancement of its stability. Park, S.W., Lee, J.W., Hong, S.I., Kim, S.W. Appl. Biochem. Biotechnol. (2003) [Pubmed]
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