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Chemical Compound Review

AC1LAD18     4-[3-(4-fluorophenyl)propyl]- 1,3-dimethyl...

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Disease relevance of Tetrahydropyridine


High impact information on Tetrahydropyridine


Chemical compound and disease context of Tetrahydropyridine


Biological context of Tetrahydropyridine


Associations of Tetrahydropyridine with other chemical compounds


Gene context of Tetrahydropyridine

  • 1. The tetrahydropyridine trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine (t-THP), like MPTP, can undergo monoamine oxidase (MAO)-mediated conversion to a dihydropyridinium intermediate and subsequent metabolism to a pyridinium species. t-THP is also a better substrate for MAO B than MAO A [18].
  • The results of these studies provide additional insights into the steric features of the active site of MAO-B and predict that the area in which the C(4) substituent of the tetrahydropyridine ring resides lacks a reactive nucleophilic group [19].
  • CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo [20].
  • Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency [21].


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