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Chemical Compound Review

Pinosylvin     5-[(E)-2- phenylethenyl]benzene-1,3- diol

Synonyms: Pinosylvine, PubChem19089, CPD-438, CHEMBL101506, SureCN454262, ...
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High impact information on AIDS009475


Biological context of AIDS009475

  • Therefore, we have attempted to determine whether pinosylvin can inhibit the expression of cytokines possessing NF-kappaB binding sites in their promoter regions [4].
  • Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics [5].
  • The acute intravenous dose of pinosylvin yielded the plasma AUC, urine t(1/2), CL and V(d) values of 5.23+/-1.20 mug h mL(-1), 13.13+/-2.05 h, 1.84+/-0.44 Lh(-1) kg(-1) and 2.29+/-0.56 L kg(-1)(mean+/-s.e.m.), respectively [6].
  • A method of analysis of pinosylvin in biological fluids is necessary to study the kinetics of in vitro and in vivo metabolism and determine its concentration in natural products [5].

Anatomical context of AIDS009475

  • A novel and simple high-performance liquid chromatographic method was developed for simultaneous determination of pinosylvin and products of its metabolism in rat serum and liver microsomes [5].
  • We have tested the effect of the phytoalexins lubimin, (-)-maackiain and pinosylvin and the related compounds dehydroloroglossol and hordatine M on the growth of the human lymphoblastoid cell lines Molt and Raji [7].

Associations of AIDS009475 with other chemical compounds


Gene context of AIDS009475


Analytical, diagnostic and therapeutic context of AIDS009475


  1. A stilbene synthase from Japanese red pine (Pinus densiflora): implications for phytoalexin accumulation and down-regulation of flavonoid biosynthesis. Kodan, A., Kuroda, H., Sakai, F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Molecular cloning and functional expression of a stress-induced multifunctional O-methyltransferase with pinosylvin methyltransferase activity from Scots pine (Pinus sylvestris L.). Chiron, H., Drouet, A., Claudot, A.C., Eckerskorn, C., Trost, M., Heller, W., Ernst, D., Sandermann, H. Plant Mol. Biol. (2000) [Pubmed]
  3. Characterization of a pine multigene family containing elicitor-responsive stilbene synthase genes. Preisig-Müller, R., Schwekendiek, A., Brehm, I., Reif, H.J., Kindl, H. Plant Mol. Biol. (1999) [Pubmed]
  4. Involvement of nuclear factor-kappaB in the inhibition of pro-inflammatory mediators by pinosylvin. Lee, J., Jung, E., Lim, J., Lee, J., Hur, S., Kim, S.S., Lim, S., Hyun, C.G., Kim, Y.S., Park, D. Planta Med. (2006) [Pubmed]
  5. Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics. Roupe, K., Halls, S., Davies, N.M. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  6. Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats. Roupe, K.A., Y????ez, J.A., Teng, X.W., Davies, N.M. J. Pharm. Pharmacol. (2006) [Pubmed]
  7. The effect of the phytoalexins, lubimin, (-)-maackiain, pinosylvin, and the related compounds dehydroloroglossol and hordatine M on human lymphoblastoid cell lines. Skinnider, L., Stoessl, A. Experientia (1986) [Pubmed]
  8. Antifungal activity of stilbenes in in vitro bioassays and in transgenic Populus expressing a gene encoding pinosylvin synthase. Seppänen, S.K., Syrjälä, L., von Weissenberg, K., Teeri, T.H., Paajanen, L., Pappinen, A. Plant Cell Rep. (2004) [Pubmed]
  9. In vitro inhibition of Sphaeropsis sapinea by natural stilbenes. Celimene, C.C., Smith, D.R., Young, R.A., Stanosz, G.R. Phytochemistry (2001) [Pubmed]
  10. Inhibitory effects of cis- and trans-isomers of 3,5-dihydroxystilbene on the activity of mushroom tyrosinase. Song, K.K., Huang, H., Han, P., Zhang, C.L., Shi, Y., Chen, Q.X. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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