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Chemical Compound Review:

Panaxytriol heptadec-1-en-4,6-diyne- 3,9,10-triol

Synonyms: AG-H-50819, AC1L3QAA, CTK3E9251, LMFA05000027, AR-1C3355, ...

Matsunaga, H. et al., Kim, J.Y. et al., Matsunaga, H. et al., Nakano, Y. et al., Matsunaga, H. et al., et al.

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High impact information on Panaxytriol

Panaxytriol, a polyacetylenic compound, isolated from red ginseng (Panax ginseng C.A. Meyer), was studied to determine its effects on the growth and cell cycle of tumor cell lines [1].
Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol [1].
The IC50 value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 microM, respectively [2].
Our preliminary studies indicated that panaxytriol localizes to the mitochondria in human breast carcinoma cells (Breast M25-SF) [3].
The results indicate that panaxytriol rapidly inhibits cellular respiration and disrupts cellular energy balance in Breast M25-SF [3].

Biological context of Panaxytriol

Particularly, the proportion of cells in the G2/M phase of the cell cycle increased from 9 % to 26 and 48 %, respectively, after 24 and 36 h exposure to panaxytriol at 5 microg/ml [1].

Anatomical context of Panaxytriol

In this paper, the effect of panaxytriol on the cytotoxicity of mitomycin C (MMC) against a human gastric carcinoma cell line, MK-1, was investigated [4].
In addition, they suggest that the enhanced accumulation of MMC in MK-1 cells treated with panaxytriol can probably be attributed to the decreased fluidity of the cell membrane caused by panaxytriol [4].

Associations of Panaxytriol with other chemical compounds

A 1-h treatment with 180 microM panaxytriol causes a significant loss of rhodamine-123 from cells with mitochondria prestained with rhodamine-123 (by flow cytometry) [3].
From the proton and carbon-13 nuclear magnetic resonance spectra, it was identified as heptadeca-1-ene-4,6-diyne-3,9,10-triol (panaxytriol) [5].
Methanol extracts of 36 samples of 21 Umbelliferae plants were screened for polyacetylenic compounds using the ELISA for panaxytriol, and their antiproliferative activity was checked by MTT assay using the tumor cell lines MK-1, HeLa and B16F10 [6].

Gene context of Panaxytriol

In contrast, when MK-1 cells were exposed to panaxytriol and then to MMC, only an additive effect was induced [4].

Analytical, diagnostic and therapeutic context of Panaxytriol

After treatment with 180 microM panaxytriol, cellular ATP levels were 40% of those in control cells after 1 h [3].
Determination of panaxytriol, a new type of tumour growth inhibitor from Panax ginseng, by capillary gas chromatography [7].
Specific toxic changes were observed by electron microscopy in the mitochondria of Breast M25-SF within 1 h after treatment with more than 180 microM panaxytriol [3].
Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol [8].

References

Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol. Kim, J.Y., Lee, K.W., Kim, S.H., Wee, J.J., Kim, Y.S., Lee, H.J. Planta Med. (2002) [Pubmed]
Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium. Wang, C.N., Shiao, Y.J., Kuo, Y.H., Chen, C.C., Lin, Y.L. Planta Med. (2000) [Pubmed]
A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration. Matsunaga, H., Saita, T., Nagumo, F., Mori, M., Katano, M. Cancer Chemother. Pharmacol. (1995) [Pubmed]
Potentiation of cytotoxicity of mitomycin C by a polyacetylenic alcohol, panaxytriol. Matsunaga, H., Katano, M., Saita, T., Yamamoto, H., Mori, M. Cancer Chemother. Pharmacol. (1994) [Pubmed]
Studies on the panaxytriol of Panax ginseng C. A. Meyer. Isolation, determination and antitumor activity. Matsunaga, H., Katano, M., Yamamoto, H., Mori, M., Takata, K. Chem. Pharm. Bull. (1989) [Pubmed]
Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. Nakano, Y., Matsunaga, H., Saita, T., Mori, M., Katano, M., Okabe, H. Biol. Pharm. Bull. (1998) [Pubmed]
Determination of panaxytriol, a new type of tumour growth inhibitor from Panax ginseng, by capillary gas chromatography. Matsunaga, H., Katano, M., Yamamoto, H., Mori, M., Takata, K., Nishi, M. J. Chromatogr. (1989) [Pubmed]
Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol. Saita, T., Katano, M., Matsunaga, H., Kouno, I., Fujito, H., Mori, M. Biol. Pharm. Bull. (1995) [Pubmed]

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