The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NR4BP     1-(2-chloroethyl)-1-nitroso- 3-[(2S,3R,4R...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CHLOROZOTOCIN

  • Administration of polyinosinic-polycytidylic acid with CZT restored the NK cell cytotoxicity of LIC and inhibited lung metastases amplification [1].
  • Administration of repeated high doses of 7.5 mg chlorozotocin [(CZT) CAS: 54749-90-5]/kg to syngeneic WAG rats bearing the rhabdomyosarcoma 9-4/0 enhanced the incidence of spontaneous metastasis compared to its incidence in untreated rats [1].
  • It was observed that a single injection of 20 mg/kg body weight of BCNU or CLZ, even at an advanced stage of tumor growth, completely cured greater than 90% of the tumor-bearing mice [2].
  • Following treatment of tumor-bearing mice with BCNU or CLZ, tumor-specific delayed type hypersensitivity responses were demonstrable in these mice but not in STZ-treated mice [2].
  • Both derived lines proved to be more aggressive than the parental, proliferated more rapidly, and were resistant to CZT toxicity [3].

High impact information on CHLOROZOTOCIN

  • However, when alkylations are measured per microgram of protein, the ratio of covalently bound drug to RNP:matricin was 1.2 for both CLZ and CCNU [4].
  • Alkylation of the nuclear matrix by chlorozotocin (CLZ) or 1-(2-chloroethyl-3-cyclohexyl)-1-nitrosourea (CCNU) was 1.58 and 1.27 pmoles drug/micrograms protein, respectively, whereas carbamoylation by CCNU was 32.5 pmoles/micrograms [4].
  • Also, addition of growth factors such as IL-1, IL-2, IL-4 and IL-6 failed to reconstitute the defective responsiveness of BCNU- and CLZ-treated T cells and macrophages [5].
  • Treatment of C57BL/6 mice with 5 intraperitoneal injections of 20 mg/kg body weight of BCNU or CLZ caused an increase in the percentage of CD4(-)CD8- T cells and a decrease in the percentage of CD4(+)CD8+ T cells in the thymus [5].
  • When T cells in the spleens of nitrosourea-treated mice were functionally analysed, it was observed that BCNU and CLZ caused a dramatic decrease in the T cell responsiveness to ConA, anti-CD3 and phorbol myristate acetate plus calcium ionophore stimulation [5].

Chemical compound and disease context of CHLOROZOTOCIN


Biological context of CHLOROZOTOCIN

  • There were considerable differences in tumor-inhibitory activity, with HeCNU ranking first and CZT last, and the rank order was similar for drug-induced lethality or bone marrow damage (in terms of reduced cellularity or macromolecular DNA damage) [7].
  • Two CZT-resistant lines, R3 and R9, showed no common aberration, but R9 which was most resistant, was shown to have a homogeneously staining region, which is usually thought to be the site of gene amplification [8].

Anatomical context of CHLOROZOTOCIN

  • Using the accessory cell-dependent and -independent assays, BCNU and CLZ were found to suppress the functions of both T cells and macrophages [5].


  1. Enhancement of pulmonary metastases induced by decreased lung natural killer cell activity. Nolibé, D., Poupon, M.F. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Immunomodulation by various nitrosoureas and its effect on the survival of the murine host bearing a syngeneic tumor. Nagarkatti, M., Toney, D.M., Nagarkatti, P.S. Cancer Res. (1989) [Pubmed]
  3. In vivo emergence of a highly metastatic tumour cell line from a rat rhabdomyosarcoma after treatment with an alkylating agent. Antoine, E., Pauwels, C., Verrelle, P., Lascaux, V., Poupon, M.F. Br. J. Cancer (1988) [Pubmed]
  4. Alkylating agent interactions with the nuclear matrix. Tew, K.D., Wang, A.L., Schein, P.S. Biochem. Pharmacol. (1983) [Pubmed]
  5. Immunomodulatory effects of nitrosoureas on the phenotype and functions of T cells in the thymus and periphery. Clary, S., Nagarkatti, P.S., Nagarkatti, M. Immunopharmacology (1990) [Pubmed]
  6. Use of pancreatic beta cells in culture to identify diabetogenic N-nitroso compounds. Wilson, G.L., Mossman, B.T., Craighead, J.E. In vitro. (1983) [Pubmed]
  7. Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system. Osieka, R., Glatte, P., Pannenbäcker, R., Schmidt, C.G. Cancer Chemother. Pharmacol. (1983) [Pubmed]
  8. Chromosome analysis of rat tumor cell lines associated with metastatic potential and drug resistance. Haus, O., Pauwels, C., Poupon, M.F., Berger, R. Invasion Metastasis (1986) [Pubmed]
WikiGenes - Universities