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Chemical Compound Review:

Flubason (8S,9S,10S,11S,13S,14S,16R,17S )-9-fluoro...

Synonyms: Esperson, Topicort, Stiedex, Topisolon, Ibaril, ...

Kim, D.S. et al., Hebert, A.A. et al., Levitt, J. et al., Willis, I. et al., Lange, K. et al., et al.

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Disease relevance of desoximetasone

Florid Cushing's syndrome and hirsutism induced by desoximetasone [1].
Although efficacy appears equivalent to that of fluocinonide gel 0.05% in treating psoriasis of the scalp, desoximetasone appears to be slightly better tolerated and better accepted cosmetically [2].
Randomized double-blind placebo-controlled trial in the treatment of alopecia areata with 0.25% desoximetasone cream [3].
We aimed to evaluate the efficacy of twice-daily simultaneous application of desoximetasone and tacrolimus in the treatment of atopic dermatitis versus tacrolimus monotherapy [4].
Of note, pruritus at the application site was diminished in subjects treated with desoximetasone and tacrolimus together compared with tacrolimus alone (P=.04) [4].

High impact information on desoximetasone

Fibroblasts were kept in monolayer cultures and were exposed to corticosteroids demonstrating similar anti-inflammatory activity (prednicarbate, desoximetasone) [5].
Whereas PC and PEP inhibited Il-1alpha and Il-6 production in fibroblasts only to a minor extent, cytokine synthesis was strongly affected by the conventional glucocorticoids BMV and DM, but also by DCE [6].
We discuss the uncommon finding of cross-reactions to desoximetasone and mometasone furoate [7].
A 1:1 (w/w) mixture of desoximetasone ointment 0.25% (Topicort, Taro Pharmaceuticals USA, Inc.) and tacrolimus ointment 0.1% (Protopic, Fujisawa Healthcare, Inc.) were prepared and stored under three different temperature/relative humidity conditions: 25 degrees C/60% RH; 30 degrees C/60% RH; and 40 degrees C/75% RH [8].
The effects of GDF-5 and other growth factors (epidermal growth factor, EGF; TGF-beta 1) on the proliferation of human keratinocytes and fibroblasts compared with desoximetasone and calcipotriol have been investigated [9].

Biological context of desoximetasone

Calcipotriol and desoximetasone also showed a dose-dependent cell growth inhibition in epidermal cell cultures [9].

Gene context of desoximetasone

Calcipotriol and desoximetasone also inhibited cell growth in fibroblast cultures whereas proliferation and DNA synthesis were strongly stimulated by 1 ng/ml EGF [9].

Analytical, diagnostic and therapeutic context of desoximetasone

Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis [2].

References

Florid Cushing's syndrome and hirsutism induced by desoximetasone. Himathongkam, T., Dasanabhairochana, P., Pitchayayothin, N., Sriphrapradang, A. JAMA (1978) [Pubmed]
Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis. Willis, I., Cornell, R.C., Penneys, N.S., Zaias, N. Clinical therapeutics. (1986) [Pubmed]
Randomized double-blind placebo-controlled trial in the treatment of alopecia areata with 0.25% desoximetasone cream. Charuwichitratana, S., Wattanakrai, P., Tanrattanakorn, S. Archives of dermatology. (2000) [Pubmed]
Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. Hebert, A.A., Koo, J., Fowler, J., Berman, B., Rosenberg, C., Levitt, J. Cutis; cutaneous medicine for the practitioner (2006) [Pubmed]
Influence of corticosteroids on chemotactic response and collagen metabolism of human skin fibroblasts. Hein, R., Mauch, C., Hatamochi, A., Krieg, T. Biochem. Pharmacol. (1988) [Pubmed]
Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids. Lange, K., Kleuser, B., Gysler, A., Bader, M., Maia, C., Scheidereit, C., Korting, H.C., Schäfer-Korting, M. Skin Pharmacol. Appl. Skin Physiol. (2000) [Pubmed]
Cross-reactions to desoximetasone and mometasone furoate in a patient with multiple topical corticosteroid allergies. Donovan, J.C., Dekoven, J.G. Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group. (2006) [Pubmed]
Compatibility of desoximetasone and tacrolimus. Levitt, J., Feldman, T., Riss, I., Leung, O.T. Journal of drugs in dermatology : JDD. (2003) [Pubmed]
Effects of growth factors on the proliferation of human keratinocytes and fibroblasts in vitro. Kim, D.S., Korting, H.C., Schäfer-Korting, M. Die Pharmazie. (1998) [Pubmed]

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