Disease relevance of DCE

• The activity levels of a dynorphin converting enzyme (DCE), a substance P endopeptidase (SPE) and a substance P alpha-amidating enzyme (SP-GLYE) were measured in the cerebrospinal fluid (CSF) of 90 patients with chronic low back pain, sciatica and neurological signs of rhizopathy [1].
• CONCLUSION: DCE MRI and 1H-MRS has potential to characterize orthotopic Dunning prostate cancer in rats, which is a promising model similar to human prostate carcinomas [2].
• MATERIALS AND METHODS: The pelvis of 24 patients with multiple myeloma (MM) was examined using contrast-enhanced DCE MRI [3].
• Data from others investigators show that when DCE was given to patients in daily doses, the dose-limiting toxicity [4].
• First, amylovorin L471, produced by Lactobacillus amylovorus DCE 471, was selected for the optimisation of the loading and eluting conditions [5].

Psychiatry related information on DCE

• Furthermore, DCE reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Daucus carota extract (200, 400 mg/kg, p.o.) reduced significantly the brain acetylcholinesterase activity and cholesterol levels in young and aged mice [6].

High impact information on DCE

• Our findings also demonstrate that CK2 activity alters TFIID-dependent recognition of DCE sequences [7].
• The DCE functions in concert with the beta-globin CATA box and initiator element, as well as in a heterologous, TATA-less context [8].
• Scanning mutagenesis from +10 to +45 indicates that this region contains a functional cis element(s) in vitro, and we designated this element the DCE (downstream core element) [8].
• DT-PACE (dexamethasone/thalidomide/cisplatin/doxorubicin/cyclophosphamide/etoposide) was offered to patients with preceding standard dose therapy, but no prior autotransplantation, while DCEP-T (dexamethasone/cyclophosphamide/etoposide/cisplatin/thalidomide) was administered for relapse after transplantation [9].
• The reductive dehalogenation of perchloroethylene and trichloroethylene by vitamin B(12) produces approximately 95% (Z)-dichloroethylene (DCE) and small amounts of (E)-DCE and 1,1-DCE, which are further reduced to ethylene and ethane [10].

Chemical compound and disease context of DCE

• Six Lactobacillus strains including commercial probiotic ones (L. acidophilus IBB 801, L. amylovorus DCE 471, L. casei Shirota, L. johnsonii La1, L. plantarum ACA-DC 287 and L. rhamnosus GG) were investigated, through batch fermentations under controlled conditions, for their capacity to inhibit Salmonella enterica serovar Typhimurium SL1344 [11].
• The toxicity of 1,2-Dichloroethane, DCE, toxicity was measured in an Electron-Microscopy (EM) preparation laboratory by Gas Chromatography [12].
• DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma [13].

Biological context of DCE

• For the ET reaction, its kinetics can be evaluated by scanning electrochemical microscopy, and the results show that the relationship between rate constants and driving force at the unmodified W/DCE interface obeys the Butler-Volmer equation in a rather wide potential region [14].
• The sex difference in DCE activity provides further evidence in favor of the role of gender in the psychoendocrine coping with pain distress [1].
• Neighbour-joining trees calculated separately for the two main clades based on chord distance (DCE) of microsatellite allele frequencies were consistent with phylogenetic trees obtained from the sequence data [15].
• The AUC values for all of the DCE metabolites from (S)-IFF were significantly greater than those from (R)-IFF with 47% of the measured AUC accounted for by DCE from (S)-IFF compared to only 20% for (R)-IFF [16].
• In agreement with this, the mustard complexes have IC50 values in cells little different to those of the free mustards even under aerobic conditions, and do not show hypoxic selectivity in a clonogenic assay under conditions where the corresponding 3-methylacac complex of DCE showed significant selectivity [17].

Anatomical context of DCE

• PURPOSE: To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens [3].
• Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is a method of imaging the physiology of the microcirculation [18].
• Significant DCE activity also was detected in hemolymph samples from adult, female A. aegypti, and undoubtedly plays a role in melanotic encapsulation reactions [19].
• Whereas PC and PEP inhibited Il-1alpha and Il-6 production in fibroblasts only to a minor extent, cytokine synthesis was strongly affected by the conventional glucocorticoids BMV and DM, but also by DCE [20].
• Four groups of eight teeth each were cut to expose planar dentin sections and treated with (a) light-cure system with acetone as solvent (LCA group); (b) light-cure system with ethanol as solvent (LCE group); (c) dual-cure system with acetone as solvent (DCA group); and (d) dual-cure system with ethanol as solvent (DCE group) [21].

Associations of DCE with chemical compounds

• In this work, ion transfer (IT), facilitated ion transfer (FIT) of protonated dopamine, and electron transfer (ET) between dopamine and ferrocene are investigated at the water/1,2-dichloroethane (W/DCE) interface [14].
• The effect of perchlorate concentration in the DCE phase on interfacial reactions has been studied in detail [22].
• Transformation products of PCE identified in dosed dithionite-treated samples included TCE, DCE, 1,1,2-trichloroethane (TCA), 1,1-dichloroethane (DCA), chloroacetylene, acetylene, ethene, and ethane [23].
• A phase I study was carried out with the new aromatic retinoic acid analogue DCE, all-trans-9-(2,6-dichloro-4-methoxy-m-tolyl)-3,7-dimethyl-2,4,6,8- nonatetraenacetylester [4].
• At an [H2](aq) of 10 microM (P/Po = 0.01), DCE isomers and vinyl chloride accounted for as much as 9.8% of the TCE transformed at their maximum but disappeared thereafter, and C4-C6 radical coupling products accounted for as much as 18% of TCE transformed [24].

Other interactions of DCE

• The purpose of our study was the investigation of early changes in tumor vascularization during antiangiogenic therapy with the vascular endothelial growth factor (VEGF) receptor 2 antibody (DC101) using dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) [25].
• The significance of the recombinant DCE in accelerating the melanization pathway is demonstrated by a rapid production of melanin in a dopa and tyrosinase reaction mixture in the presence of recombinant DCE [26].

Analytical, diagnostic and therapeutic context of DCE

• The feasibility of a voxel-by-voxel deconvolution analysis of T(1)-weighted DCE data in the human kidney and its potential for obtaining quantification of perfusion and filtration was investigated [27].
• A practical approach for quantitative estimates of voxel-by-voxel liver perfusion using DCE imaging and a compartmental model [28].
• Clinical research has shown that, for tumors such as bone sarcomas, reliable outcome measures of tumor response to chemotherapy can be extracted from DCE MRI by methods ranging from simple measures of enhancement to pharmacokinetic models [18].
• Twenty-seven patients with prostate cancers were examined with DCE MRI prior radical prostatectomy [29].
• Radiography with double-contrast medium (DCE), which can be performed in patients not critically ill, often yields pathognomonic findings and permits early diagnosis [30].

References