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Chemical Compound Review

AC1NSKJO     (Z)-7-[(1S,4R,5S,6R)-5-[[2...

Synonyms: SureCN9241897, SQ-30741, SQ30741, SQ 30741, 107332-47-8
 
 
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High impact information on SQ30741

  • Contraction was significantly attenuated after pretreatment of the vessel segments with ketanserin (5-HT2 receptor antagonist, 1 mumol/L) or SQ30741 (TXA2 receptor antagonist, 0.01 mumol/L), reaching 8.8 +/- 2.3% and 3.2 +/- 2.2% of contraction to 100 mmol/L K+, respectively [1].
  • The potent contraction to thrombin-activated platelets (1000 to 75,000/microL) in arteries without endothelium was markedly inhibited by the thromboxane A2 synthetase/receptor antagonist ridogrel (10(-5) mol/L; P < .005 versus control) and the single-acting thromboxane receptor blocker SQ-30741 (10(-7) mol/L; P < .01 versus control) [2].
  • In contrast, neither thromboxane synthase inhibition with dazmegrel nor thromboxane receptor blockade with SQ 30741 caused a significant change in collateral flow, thus failing to support thromboxane-induced collateral constriction [3].
  • Endothelium-dependent contractions to acetylcholine were unmasked by NG-nitro-L-arginine methyl ester (P < .05) and prevented by SQ 30741 or endothelium removal [4].
  • The thromboxane A2 (TXA2)/prostaglandin H2 (PGH2) receptor antagonist, SQ30741, reduced both sensitivity and maximal contraction to NPY in PRA but not in DRA [5].
 

Biological context of SQ30741

 

Anatomical context of SQ30741

 

Associations of SQ30741 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of SQ30741

  • Administration of SQ 30741 failed to ameliorate the pulmonary pressor response of the graft in comparison with the control group [7].

References

  1. Low-dose aspirin inhibits platelet-induced contraction of the human isolated coronary artery. A role for additional 5-hydroxytryptamine receptor antagonism against coronary vasospasm? Bax, W.A., Renzenbrink, G.J., van der Linden, E.A., Zijlstra, F.J., van Heuven-Nolsen, D., Fekkes, D., Bos, E., Saxena, P.R. Circulation (1994) [Pubmed]
  2. Thrombin-induced endothelium-dependent inhibition and direct activation of platelet-vessel wall interaction. Role of prostacyclin, nitric oxide, and thromboxane A2. Yang, Z., Arnet, U., Bauer, E., von Segesser, L., Siebenmann, R., Turina, M., Lüscher, T.F. Circulation (1994) [Pubmed]
  3. The mechanism of coronary collateral vasoconstriction in response to cyclooxygenase blockade. Altman, J.D., Bache, R.J. Circ. Res. (1994) [Pubmed]
  4. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Küng, C.F., Lüscher, T.F. Hypertension (1995) [Pubmed]
  5. Regional involvement of an endothelium-derived contractile factor in the vasoactive actions of neuropeptide Y in bovine isolated retinal arteries. Prieto, D., Simonsen, U., Nyborg, N.C. Br. J. Pharmacol. (1995) [Pubmed]
  6. Magnitude of thromboxane receptor antagonism necessary for antithrombotic activity in monkeys. Schumacher, W.A., Heran, C.L., Goldenberg, H.J., Harris, D.N., Ogletree, M.L. Am. J. Physiol. (1989) [Pubmed]
  7. Thromboxane receptor blockade does not attenuate pulmonary pressor response in porcine single lung transplantation. Kukkonen, S., Heikkilä, L., Verkkala, K., Mattila, S., Toivonen, H. J. Heart Lung Transplant. (1996) [Pubmed]
  8. Thrombopoietin increases platelet adhesion under flow and decreases rolling. Van Os, E., Wu, Y.P., Pouwels, J.G., Ijsseldijk, M.J., Sixma, J.J., Akkerman, J.W., De Groot, P.G., Van Willigen, G. Br. J. Haematol. (2003) [Pubmed]
  9. Interaction between thromboxane A2 and 5-hydroxytryptamine in the radial artery compared to the internal thoracic artery. Chester, A.H., Amrani, M., Sproson, C.A., Yacoub, M.H. Gen. Pharmacol. (2000) [Pubmed]
 
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