Disease relevance of Sudan Orange RRA

• Areas of myelin breakdown and demyelination were determined using a staining for neutral lipids, Oil Red O (ORO) [1].
• Electron microscope investigations on leishmaniasis in the Sudan: II. Ultrastructural morphology of macrophage-parasite interaction in human and hamster macrophages in vivo [2].
• Tsetse and trypanosomiasis survey of Southern Darfur province, Sudan. II. Entomological aspects [3].
• Epidermal hyperplasia induced in guinea pig flank skin by intradermal injection of Sudan red [4].

Psychiatry related information on Sudan Orange RRA

• Epidemiology of nocturnal enuresis in a part of Khartoum, Sudan. II. The intensive study [5].

High impact information on Sudan Orange RRA

• Staining of frozen sections of small parathyroid biopsies from patients with primary hyperparathyroidism with Sudan II or IV revealed the almost uniform presence of numerous prominent intracellular sudanophilic bodies in the chief cells of suppressed "normal" parathyroid glands [6].
• Furthermore, macrophages isolated from active demyelinating MS lesions were stained for iNOS, cNOS, KP1 and ORO [1].
• However, it was still lower than that of the oil particles, and the distribution of sudan II to liver, lungs, adipose tissue, heart, and muscle was not altered, and only that to brain and kidneys was decreased [7].
• The standard lipid emulsion composed of soybean oil and egg yolk phosphatides increased the blood concentration of sudan II after i.v. injection when compared with its solubilized solution by plasma [7].
• Pure quinone reductase was obtained from the livers of Sudan II (1-[2,4-dimethylphenylazo]-2-naphthol)-treated rats in a single step by Cibacron Blue-agarose chromatography [8].

Biological context of Sudan Orange RRA

• O/W lipid emulsions for parenteral drug delivery. I. Pharmacokinetics of the oil particles and incorporated sudan II [9].

Anatomical context of Sudan Orange RRA

• The enzyme-sensitive enteric vehicles when containing sudan II did not release the dye in the stomach of rats after oral administration, but released significant amounts of the dye in the small intestine [10].
• Sudan red staining demonstrated multiple plaques in the aortic arch of all WHHL rabbits [11].
• Nymphs and adult ticks were age graded by dissection of gut and Malpighian tubules and staining for lipid with Sudan red [12].

Associations of Sudan Orange RRA with other chemical compounds

• These vehicles readily dissolved the poorly water-soluble compounds used in the study, itazigrel, indomethacin and the dye, sudan II, and were digested by lipase and esterase, releasing the test drugs with time profiles similar to those observed in dissolution studies [10].

Analytical, diagnostic and therapeutic context of Sudan Orange RRA

• In the case of sudan II (clog P = 5.4), the release from the oil particles was very quick after intravenous injection, resulting in slight alteration in biodistribution when compared with its micellar solution [13].
• The potential usefulness of O/W lipid emulsions as injectable drug delivery systems for lipophilic drugs was examined using a model lipophilic drug, sudan II (clogP = 5.4) in the normal rats [7].

References